全文获取类型
收费全文 | 1724篇 |
免费 | 98篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 65篇 |
妇产科学 | 20篇 |
基础医学 | 167篇 |
口腔科学 | 41篇 |
临床医学 | 102篇 |
内科学 | 369篇 |
皮肤病学 | 48篇 |
神经病学 | 298篇 |
特种医学 | 62篇 |
外科学 | 331篇 |
综合类 | 7篇 |
预防医学 | 102篇 |
眼科学 | 10篇 |
药学 | 86篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 8篇 |
2022年 | 29篇 |
2021年 | 38篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 54篇 |
2017年 | 27篇 |
2016年 | 35篇 |
2015年 | 48篇 |
2014年 | 63篇 |
2013年 | 86篇 |
2012年 | 107篇 |
2011年 | 102篇 |
2010年 | 73篇 |
2009年 | 57篇 |
2008年 | 90篇 |
2007年 | 100篇 |
2006年 | 83篇 |
2005年 | 94篇 |
2004年 | 78篇 |
2003年 | 73篇 |
2002年 | 73篇 |
2001年 | 48篇 |
2000年 | 57篇 |
1999年 | 45篇 |
1998年 | 14篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 12篇 |
1994年 | 6篇 |
1992年 | 31篇 |
1991年 | 23篇 |
1990年 | 17篇 |
1989年 | 24篇 |
1988年 | 7篇 |
1987年 | 16篇 |
1986年 | 10篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 18篇 |
1982年 | 6篇 |
1979年 | 9篇 |
1976年 | 16篇 |
1975年 | 7篇 |
1974年 | 5篇 |
1971年 | 3篇 |
1970年 | 6篇 |
1969年 | 4篇 |
1968年 | 4篇 |
1967年 | 5篇 |
排序方式: 共有1829条查询结果,搜索用时 15 毫秒
1.
2.
Williamson Kathleen A.; Hever Ann M.; Rainger Joe; Rogers R. Curtis; Magee Alex; Fiedler Zdenek; Keng Wee Teik; Sharkey Freddie H.; McGill Niolette; Hill Clare J.; Schneider Adele; Messina Mario; Turnpenny Peter D.; Fantes Judy A.; van Heyningen Veronica; FitzPatrick David R. 《Human molecular genetics》2006,15(12):2030
Table 1 相似文献
3.
Microvascular involvement represents one of the first apparent steps in many autoimmune diseases such as rheumatoid arthritis (RA). Early in the disease, peripheral microangiopathy may be easily recognized and studied by videocapillaroscopy. The aim of this study has been to observe the differences in labial microcirculation between healthy patients and patients suffering from RA. A total of 30 healthy patients and 30 patients suffering from RA were examined. The patients with conditions known to compromise microcirculation, such as diabetes, hypertension, or some pharmacological treatments were not included in the study. All the patients were non-smokers. Labial capillaroscopy was used to investigate the characteristics of microcirculation. Visibility, course, tortuosity, as well as the possible presence of microhemorrhages, the average caliber of the capillary loops and the number of visible capillary loops per square millimeter were evaluated for each patient. The investigation was simple, non-invasive, and repeatable for each patient. In patients suffering from RA, it was possible to observe a reduced caliber of capillaries, as well as greater elongated capillaries, in comparison to controls. This study shows that capillary alterations in patients suffering from RA occur in labial mucosa microcirculation; such evidence could be extremely important in the diagnosis of suspected RA. 相似文献
4.
J Emerg Nurs 1998;24:622. 相似文献
5.
Cancers of the middle umbilical fold are very infrequent, making up 0.1% to 0.7% of all bladder tumors. This type of tumor affects male subjects in 60% to 75% of cases, in the 5th or 6th decade of life. In more than 90% of all cases, the lesion is a mucosecretory adenocarcinoma developing from embryonic remains within the wall of the bladder and respecting the superficial urothelium of the bladder, which is affected only secondarily, contrary to what occurs in the other adenocarcinomas of the bladder. The pathogenesis remains controversial, especially the role of middle umbilical fold patency and of bladder carcinogens. The diagnosis is most often established late, because of a long clinical latency. It is mainly based on ultrasonography and computed tomography. Explorations of the bladder are useful only at an advanced stage. The prognosis is very poor, survival at 5 years ranging from 6.5% to 25% according to the authors. The treatment is mainly surgical. Only extensive exeresis with partial cystectomy extending to the peri- and supravesical environment, including the peritoneum and the umbilicus, and associated with pelvic lymphadenectomy may give some hope. Chemotherapy and radiation therapy, either alone or complementary, are disappointing. The prognosis may be improved only by an early diagnosis. 相似文献
6.
7.
8.
AIMS: The aim of this study was to evaluate the anal manometric changes and the clinical effects after topical application of isosorbide dinitrate (ISDN) in patients with persistent constipation after pull-through surgery for Hirschsprung's disease (HD). METHODS: We studied 3 children (2 males and 1 female), aged 2, 3 and 5 years respectively, who had undergone the Soave-Boley surgical procedure for HD and who suffered from persistent constipation after operation. We performed a pre- and postoperative anorectal manometry study and we applied ISDN paste (1 mg/kg two times daily) in the anal region for three weeks. All patients were followed-up and re-evaluated at 1, 3, and 6 months. RESULTS: All patients showed an improvement of symptoms, with an average of 4 spontaneous evacuations per week. Prior to the topical treatment, the medium pressure was 115.6 mmHg (range 102 - 130 mmHg), the maximum pressure was 160 mmHg (range 145 - 175 mmHg), and the medium length of the high pressure zone was 1.8 cm (range 1.5 - 2.0 cm). At the 6 month follow-up, the medium pressure was 57.3 mmHg (range 52 - 61 mmHg, a decrease of 54.4 %), the maximum pressure was 98 mmHg (range 88 - 107 mmHg; a decrease of 38.7 %), and the medium length of the high pressure zone was 1.6 cm (range 1.4 - 1.8 cm; a decrease of 11.1 %). CONCLUSIONS: Topical treatment with ISDN is a valid therapeutic alternative to an anal myotomy in patients with persistent constipation after pull-through surgery for HD. However, a greater number of cases and a longer follow-up are necessary to confirm the validity of our experience. 相似文献
9.
Cutaneous T-cell lymphoma 总被引:1,自引:0,他引:1
10.
Glomerular epithelial abnormalities associated with the onset of proteinuria in aminonucleoside nephrosis. 总被引:2,自引:4,他引:2 下载免费PDF全文
A. Messina D. J. Davies P. C. Dillane G. B. Ryan 《The American journal of pathology》1987,126(2):220-229
A sequential ultrastructural study has been made of glomerular podocytic epithelium before and after the onset of proteinuria induced by daily subcutaneous injections of low doses of puromycin aminonucleoside (PAN). At 4 days, before the onset of proteinuria, the principal change was extensive replacement of podocytic foot processes by broad expanses of epithelial cytoplasm. At 5 days, when proteinuria had developed, the epithelial cells showed in addition multiple cytoplasmic droplets, many large balloon like vacuoles, some of which were ruptured, and many foci of epithelial detachment from the glomerular basement membrane (GBM). Of particular significance, the onset of proteinuria coincided precisely with the development of areas of epithelial detachment that led to direct continuity between externally denuded GBM and the urinary space. It seems likely that these areas are the primary sites of protein leakage across the GBM in this experimental model. 相似文献