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Pasquale Vergara MD PhD Carlo Pignalberi MD Ennio C. Pisanò MD Giampiero Maglia MD Paolo Della Bella MD Gabriele Zanotto MD Saverio Iacopino MD Francesco Solimene MD Valeria Calvi MD Massimiliano Marini MD Massimo Giammaria MD Mauro Biffi MD Giovanni Rovaris MD Fabrizio Caravati MD Fabio Quartieri MD Antonio Curnis MD Antonio Rapacciuolo MD PhD Gaetano Senatore MD Stefano Pedretti MD Davide Saporito MD Antonio Dello Russo MD Vincenzo E. Santobuono MD PhD Patrizia Pepi MD Antonio Duca MD Matteo Baroni MD Giulio Falasconi MD Daniele Giacopelli MSc Alessio Gargaro MSc Antonio D'Onofrio MD 《Journal of cardiovascular electrophysiology》2021,32(9):2528-2535
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Alessandro Mandurino-Mirizzi Vilma Kajana Stefano Cornara Alberto Somaschini Andrea Demarchi Marco Galazzi Gabriele Crimi Marco Ferlini Rita Camporotondo Massimiliano Gnecchi Maurizio Ferrario Luigi Oltrona-Visconti Gaetano M. De Ferrari 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(7):2140-2143
BackgroundContrast associated-acute kidney injury (CA-AKI) has been associated with adverse outcomes after ST-segment elevation myocardial infarction (STEMI). However, early markers of CA-AKI are still needed to improve risk stratification. We investigated the association between elevated serum uric acid (eSUA) and CA-AKI in patients with STEMI treated with primary percutaneous coronary intervention (pPCI).Methods and resultsSerum creatinine (Scr) was measured at admission and 24, 48 and 72 h after pPCI. CA-AKI was defined as an increase of 25% (CA-AKI 25%) or 0.5 mg/dl (CA-AKI 0.5) of Scr level above the baseline after 48 h following contrast administration. Multivariable analyses to investigate CA-AKI predictors were performed by binary logistic regression and multivariable backward logistic regression model.In the 3023 patients considered, CA-AKI was more frequent among patients with eSUA as compared with patients with normal SUA levels, considering both CA-AKI definitions (CA-AKI25%: 20.8% vs 16.2%, p < 0.012; CA-AKI 0.5: 10.1% vs 5.8%, p < 0.001). The association between eSUA and CA-AKI was confirmed at multivariable analyses (CA-AKI 25%: odd ratio 1.32, 95% CI 1.03–1.69, p = 0.027; CA-AKI 0.5: odd ratio 1.76, 95% CI 1.11–2.79, p = 0.016).ConclusionElevated serum uric acid is associated with CA-AKI after reperfusion in patients with STEMI treated with pPCI. 相似文献
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Marcus Ulrich Hentrich MD Mark Bower MD Gedske Daugaard DMSc Annette Dieing MD Markus Bickel MD Massimiliano Berretta MD Florian Lesmeister MD Vindi Jurinovic PhD Albrecht Stoehr MD Julia Heinzelbecker MD Ivanka Krznaric MD Klaus-Peter Dieckmann MD Andrea Necchi MD Pablo Maroto Rey MD Jürgen Kurt Rockstroh MD Margarida Brito MD David Pfister MD Christian Hoffmann MD 《Cancer》2022,128(2):260-268
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Vergunst Francis Chadi Nicholas Orri Massimiliano Brousseau-Paradis Camille Castellanos-Ryan Natalie Séguin Jean R. Vitaro Frank Nagin Daniel Tremblay Richard E. Côté Sylvana M. 《European child & adolescent psychiatry》2022,31(11):1729-1738
European Child & Adolescent Psychiatry - Substance abuse is a significant public health concern that disproportionately burdens males and low-income communities. This study examined (1)... 相似文献
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Iren Yeeling Wu Trygg Einar Nikolaisen Nataša Škalko-Basnet Massimiliano Pio di Cagno 《Journal of pharmaceutical sciences》2019,108(8):2570-2579
Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant because of physiological and environmental factors, and this might limit the therapeutic outcome of nanocarrier-based formulations. To shine light on the impact of environmental ionic strength on nanocarrier-based formulations, we have studied how liposomal formulations respond to the change of tonicity of the external environment. Large unilamellar vesicles loaded with 6 different drugs were exposed to different hypotonic environments, creating an osmotic gradient within the inner core and external environment of the liposomes up to 650 mOsm/kg. Both size and polydispersity of liposomes were significantly affected by tonicity changes. Moreover, the release kinetics of hydrophilic and lipophilic drugs were largely enhanced by hypotonic environments. These results clearly demonstrate that the environmental ionic strength has an impact on liposomal formulation stability and drug release kinetics and it should be considered when liposomal formulations for nose-to-brain targeted drug delivery are designed. 相似文献