全文获取类型
收费全文 | 7541篇 |
免费 | 441篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 231篇 |
妇产科学 | 193篇 |
基础医学 | 1023篇 |
口腔科学 | 518篇 |
临床医学 | 594篇 |
内科学 | 1478篇 |
皮肤病学 | 151篇 |
神经病学 | 539篇 |
特种医学 | 178篇 |
外科学 | 1129篇 |
综合类 | 93篇 |
预防医学 | 669篇 |
眼科学 | 193篇 |
药学 | 454篇 |
中国医学 | 42篇 |
肿瘤学 | 413篇 |
出版年
2023年 | 57篇 |
2022年 | 52篇 |
2021年 | 196篇 |
2020年 | 164篇 |
2019年 | 221篇 |
2018年 | 251篇 |
2017年 | 196篇 |
2016年 | 174篇 |
2015年 | 218篇 |
2014年 | 311篇 |
2013年 | 367篇 |
2012年 | 572篇 |
2011年 | 636篇 |
2010年 | 367篇 |
2009年 | 321篇 |
2008年 | 462篇 |
2007年 | 434篇 |
2006年 | 373篇 |
2005年 | 363篇 |
2004年 | 346篇 |
2003年 | 293篇 |
2002年 | 257篇 |
2001年 | 125篇 |
2000年 | 141篇 |
1999年 | 128篇 |
1998年 | 52篇 |
1997年 | 40篇 |
1996年 | 31篇 |
1995年 | 30篇 |
1994年 | 40篇 |
1993年 | 30篇 |
1992年 | 67篇 |
1991年 | 69篇 |
1990年 | 54篇 |
1989年 | 48篇 |
1988年 | 52篇 |
1987年 | 49篇 |
1986年 | 59篇 |
1985年 | 51篇 |
1984年 | 24篇 |
1983年 | 18篇 |
1982年 | 15篇 |
1979年 | 22篇 |
1978年 | 16篇 |
1977年 | 14篇 |
1976年 | 19篇 |
1974年 | 27篇 |
1973年 | 25篇 |
1972年 | 16篇 |
1970年 | 14篇 |
排序方式: 共有8008条查询结果,搜索用时 46 毫秒
1.
George Haddad Malte Klling Urs A. Wegmann Angela Dettling Harald Seeger Roland Schmitt Inga Soerensen-Zender Hermann Haller Andreas D. Kistler Anne Dueck Stefan Engelhardt Thomas Thum Thomas F. Mueller Rudolf P. Wüthrich Johan M. Lorenzen 《Journal of the American Society of Nephrology : JASN》2021,32(2):323
2.
3.
Evaluation of Nestin and EGFR in Patients with Glioblastoma Multiforme in a Public Hospital in Iran 下载免费PDF全文
Amir Hassan MatiniMohadeseh Mofidi NaeiniHamed Haddad KashaniZarichehr Vakili 《Asian Pacific journal of cancer prevention》2020,21(10):2889-2894
Introduction: Glioblastoma multiforme (GBM) is a grade IV glioma and accounts for 15% of all primary brain tumors. This GBM has a median survival range of less than 2 years after diagnosis and it is highly vascularized by neoformed vessels. Neoangiogenesis is a crucial factor in the malignant tumoral behavior and prognosis of patients and Nestin protein belongs to class VI which is expressed in endothelial cells of neoformed vessels in GBM. Our study shows the correlation between EGFR mutation and Nestin expression in endothelial of neoformed vessels in GBM. Methods: We analyzed 40 GBM samples by immunohistochemistry staining. The immunohistochemical expression of EGFR in tumoral cells and Nestin in endothelial cells in paraffin sections were analyzed. EGFR scoring was the based on staining intensity. Score 0 shows No staining, Score1, mild to moderate staining and score2 sever staining. Microvascular density (MVD) was evaluated with Nestin-immunoreactive. Results: The mean of MVD was 14.6 ±8.25. Nestin-MVD was significantly higher in GBM with sever vascular prolifration (p-value=0.01). EGFR was expressed in 92.5% of samples. The EGFR scoring for tumoral tissue was 7.5%(score:0), 22.5% (score:1) and 70% (score:2). There was a significant relationship between EGFR expression and MVD (p-value=0.017). Conclusion: We suggest that some important mutations as like as EGFR in GBM is responsible for inducing angiogenesis and vascular proliferation. Nestin overexpression as a novel marker might reflect the extent of neoangiogenesis, thus target therapy against EGFR pathway and anti angiogenic may be useful for GBM treatment. 相似文献
4.
5.
6.
7.
Luciana Donola Cardoso 《AIDS care》2015,27(5):629-636
Data on risky sexual behaviors in people living with HIV/AIDS (PLWHA) is still scarce in some populations around the world. The purpose of this study was to assess the factors associated with the use of condoms in a representative sample of PLWHA in outpatient treatment in the city of São Paulo. Six hundred and sixty-seven HIV-positive patients (383 men and 284 women) who were being treated at eight centers participated in this study. Data were collected using a sociodemographic survey, the Beck depression and anxiety inventories, a survey of alcohol and other drugs use, the Alcohol Use Disorders Identification Test, a sexual behavior survey, and the Sexual Risk Behavior Assessment Schedule. The majority of study participants were sexually active (almost 62% of the sample had at least one sexual partner in the last three months), and at least one-fourth engaged in unsafe sex (25.3% did not use condoms during at least one instance of anal and/or vaginal intercourse in the past three months). Multivariate logistic regression showed that engaging in unprotected sex was more likely among females (p < .001), persons with an HIV-positive partner (p < .001), and people using cannabis before sex (p = .002). These findings should stimulate health-care workers to create specific groups for women, seroconcordant couples, and cannabis users to discuss condom use, as they seem to be vulnerable groups. 相似文献
8.
Jennifer L. Brown Lisa B. Haddad Nicole K. Gause Sarah Cordes Cecilia Bess Caroline C. King 《Women & health》2019,59(3):305-317
This study qualitatively examined factors that influenced contraceptive choices in a sample of young, HIV-infected women. Individual qualitative interviews were conducted among 30 vertically and horizontally HIV-infected women (n = 26 African American) from the ages of 14 to 24 years (Mean age = 20.9 years). We recruited sample groups with the following characteristics: (a) current contraceptive/condom use with ≥1 child (n = 11); (b) current contraceptive/condom use with no children (n = 12); and (c) no current contraceptive/condom use with no children (n = 7). A semi-structured interview guide was used to ask participants about factors influencing past and current contraceptive choices. Individual interviews were digitally recorded and transcribed verbatim; analyses to identify core themes were informed by the Grounded Theoretical approach. Young, HIV-infected women did not identify their HIV serostatus or disease-related concerns as influential in their contraceptive decisions. However, they reported that recommendations from health-care providers and input from family and friends influenced their contraceptive choices. They also considered a particular method’s advantages (e.g., menstrual cycle improvements) and disadvantages (e.g., increased pill burden) when selecting a method. Findings suggested that HIV-infected young women’s contraceptive decisions were influenced by factors other than those related to their infection. 相似文献
9.
Chaves Aline Lauda Freitas Silva Ana Gabriela Maia Flávia Medeiros Lopes Gabriela Francine Martins de Paulo Luiz Fernando Barbosa Muniz Luciana Vieira dos Santos Hélio Batista Soares João Marcos Arantes Souza Alexandre Andrade de Oliveira Barbosa Leandro Augusto Loyola Adriano Mota Murta Eddie Fernando Candido Michelin Márcia Antoniaze de Azambuja Ribeiro Rosy Iara Maciel 《Clinical oral investigations》2019,23(4):1913-1919
Clinical Oral Investigations - The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4+, and CD8+ in premalignant lesions (OPML) that were transformed into oral... 相似文献
10.