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1.
Kinase alterations are increasingly recognised as oncogenic drivers in mesenchymal tumours. Infantile fibrosarcoma and the related renal tumour, congenital mesoblastic nephroma, were among the first solid tumours shown to harbour recurrent tyrosine kinase fusions, with the canonical ETV6::NTRK3 fusion identified more than 20 years ago. Although targeted testing has long been used in diagnosis, the advent of more robust sequencing techniques has driven the discovery of kinase alterations in an array of mesenchymal tumours. As our ability to identify these genetic alterations has improved, as has our recognition and understanding of the tumours that harbour these alterations. Specifically, this study will focus upon mesenchymal tumours harbouring NTRK or other kinase alterations, including tumours with an infantile fibrosarcoma-like appearance, spindle cell tumours resembling lipofibromatosis or peripheral nerve sheath tumours and those occurring in adults with a fibrosarcoma-like appearance. As publications describing the histology of these tumours increase so, too, do the variety kinase alterations reported, now including NTRK1/2/3, RET, MET, RAF1, BRAF, ALK, EGFR and ABL1 fusions or alterations. To date, these tumours appear locally aggressive and rarely metastatic, without a clear link between traditional features used in histological grading (e.g. mitotic activity, necrosis) and outcome. However, most of these tumours are amenable to new targeted therapies, making their recognition of both diagnostic and therapeutic import. The goal of this study is to review the clinicopathological features of tumours with NTRK and other tyrosine kinase alterations, discuss the most common differential diagnoses and provide recommendations for molecular confirmation with associated treatment implications. 相似文献
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Efficacy and long‐term durability of intradermal recombinant hepatitis B virus vaccine among intramuscular vaccine nonresponders: A prospective study in healthcare personnel 下载免费PDF全文
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Johanna RANTANEN Taru FELDT Jari J HAKANEN Katja KOKKO Mari HUHTALA Lea PULKKINEN Wilmar SCHAUFELI 《Industrial health》2015,53(2):113-123
Abstract: The present study investigated the factor structure of the 10-item version of
the Dutch Work Addiction Scale (DUWAS). The DUWAS-10 is intended to measure workaholism
with two correlated factors: working excessively (WE) and working compulsively (WC). The
factor structure of the DUWAS-10 was examined among multi-occupational samples from the
Netherlands (n=9,010) and Finland (n=4,567) using
confirmatory factor analysis (CFA). CFAs revealed that the expected correlated two-factor
solution showed satisfactory fit to the data. However, a second-order factor solution,
where WE comprised the first-order factors “working frantically” and “working long hours”,
and WC the first-order factors “obsessive work drive” and “unease if not working”, showed
significantly better fit to the data. The expectation of factorial group invariance of the
second-order factor structure between the Dutch and Finnish samples was also supported.
Moreover, factorial time invariance was observed across a two-year time lag in a
sub-sample of Finnish managers (n=459). In conclusion, the DUWAS-10 was
found to be a comprehensive measure of workaholism, meeting the criteria of factorial
validity in multiple settings, and can thus be recommended for use in both research and
practice. 相似文献
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Die Onkologie - Trotz Aufklärungsgespräch durch den behandelnden Arzt wird häufig eine große Diskrepanz hinsichtlich der Therapiezieleinschätzung zwischen Arzt- und... 相似文献
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Borrelli Enrico Grosso Domenico Vella Giovanna Sacconi Riccardo Battista Marco Querques Lea Zucchiatti Ilaria Prascina Francesco Bandello Francesco Querques Giuseppe 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2621-2628
Graefe's Archive for Clinical and Experimental Ophthalmology - To estimate the impact of delayed care during the coronavirus disease 2019 (COVID-19) pandemic on the outcomes of patients with... 相似文献
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