全文获取类型
收费全文 | 1997篇 |
免费 | 69篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 35篇 |
妇产科学 | 12篇 |
基础医学 | 235篇 |
口腔科学 | 21篇 |
临床医学 | 140篇 |
内科学 | 580篇 |
皮肤病学 | 31篇 |
神经病学 | 159篇 |
特种医学 | 85篇 |
外科学 | 285篇 |
综合类 | 5篇 |
预防医学 | 73篇 |
眼科学 | 43篇 |
药学 | 191篇 |
中国医学 | 3篇 |
肿瘤学 | 171篇 |
出版年
2023年 | 9篇 |
2022年 | 10篇 |
2021年 | 24篇 |
2020年 | 23篇 |
2019年 | 24篇 |
2018年 | 18篇 |
2017年 | 19篇 |
2016年 | 32篇 |
2015年 | 30篇 |
2014年 | 51篇 |
2013年 | 71篇 |
2012年 | 99篇 |
2011年 | 113篇 |
2010年 | 64篇 |
2009年 | 64篇 |
2008年 | 103篇 |
2007年 | 126篇 |
2006年 | 139篇 |
2005年 | 165篇 |
2004年 | 155篇 |
2003年 | 164篇 |
2002年 | 150篇 |
2001年 | 28篇 |
2000年 | 11篇 |
1999年 | 31篇 |
1998年 | 45篇 |
1997年 | 30篇 |
1996年 | 23篇 |
1995年 | 34篇 |
1994年 | 31篇 |
1993年 | 28篇 |
1992年 | 29篇 |
1991年 | 18篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 13篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1960年 | 1篇 |
排序方式: 共有2074条查询结果,搜索用时 109 毫秒
1.
Norio Itokawa Masanori Atsukawa Akihito Tsubota Noritomo Shimada Hidenori Toyoda Koichi Takaguchi Atsushi Hiraoka Tomonori Senoh Mai Koeda Yuji Yoshida Tomomi Okubo Taeang Arai Korenobu Hayama Ai Nakagawa-Iwashita Chisa Kondo Katsuhiko Iwakiri 《Internal medicine (Tokyo, Japan)》2021,60(4):507
Objective Pegylated-interferon monotherapy is the standard treatment for patients with chronic hepatitis B; however, the factors associated with its therapeutic effects remain unclear. Methods Patients with chronic hepatitis B were treated with pegylated interferon α-2a for 48 weeks. We evaluated the kinetics of hepatitis B surface antigen (HBsAg) during treatment and follow-up periods and the factors associated with an HBsAg response (defined as a change in HBsAg of ≥-1 log IU/mL from baseline). Results The study population comprised 50 patients. The median baseline levels of hepatitis B virus DNA and HBsAg were 5.00 and 3.40 log IU/mL. The median values of HBsAg reduction from baseline were -0.44 (n=48), -0.41 (n=40), and -0.68 (n=11) log IU/mL at the end of treatment and at 48 and 144 weeks post-treatment, respectively. The rates of HBsAg response were 24.0% and 22.5% at the end of treatment and at 48 weeks post-treatment, respectively. A multivariate analysis identified HBsAg <3.00 log IU/mL as an independent baseline factor contributing to the HBsAg response at the end of treatment and 48 weeks post-treatment (p=1.07×10-2 and 4.42×10-2, respectively). There were significant differences in the reduction of the HBsAg levels at 12 weeks of treatment and in the incidence of serum ALT increase during treatment between patients with and without an HBsAg response. Conclusion These findings suggest that the baseline HBsAg level, HBsAg kinetics at 12 weeks of treatment, and ALT increase during treatment are important factors contributing to the HBsAg response in pegylated interferon α-2a monotherapy for patients with chronic hepatitis B. 相似文献
2.
3.
Infection mechanism of biofilm‐forming Staphylococcus aureus on indwelling foreign materials in mice 下载免费PDF全文
Taro Makino Shiro Jimi Takuto Oyama Yuki Nakano Kouichi Hamamoto Kanako Mamishin Tomoko Yahiro Shuuji Hara Tohru Takata Hiroyuki Ohjimi 《International wound journal》2015,12(2):122-131
Indwelling foreign‐body infections are a critical medical problem, especially in immunocompromised patients. To examine the pathogenicity of biofilm‐forming bacteria settling on foreign materials, mice implanted with plastic discs were infected with Staphylococcus aureus. After opening a wide subcutaneous pocket on the dorsal side of mice with or without temporal leukocytopenia, a plastic sheet was placed in the left subcutaneous space; subsequently, bacteria in a planktonic state were dispersed over the subcutaneous space. Bacterial numbers were examined 7 days after inoculation. In subcutaneous tissue on the right, S. aureus was found only in leukocytopenic mice. Meanwhile, bacteria were detected on the plastic and neighbouring tissue in both leukocytopenic and normal mice; however, colony‐forming analysis indicated that leukocytopenic mice possessed significantly more bacteria. Tissue reaction against bacteria was pathologically examined. Invading S. aureus induced severe inflammation. In transient leukocytopenic mice, bacterial microcolonies formed on the plastic as well as in the developed necrotic tissue – both of which were shielded from inflammatory cell infiltration – result in bacteraemia. These results indicate that biofilm‐forming S. aureus settling on indwelling foreign material are tolerant against host immunity and assault neighbouring tissue, which may lead to chronic wound infection. 相似文献
4.
Sato Ryosuke Matsuzawa Yasushi Ogawa Hisao Kimura Kazuo Tsuboi Nobuo Yokoo Takashi Okada Hirokazu Konishi Masaaki Kirigaya Jin Fukui Kazuki Tsukahara Kengo Shimizu Hiroyuki Iwabuchi Keisuke Yamada Yu Saka Kenichiro Takeuchi Ichiro Kashihara Naoki Tamura Kouichi 《Clinical and experimental nephrology》2022,26(10):974-981
Clinical and Experimental Nephrology - Identifying predictive factors for coronavirus disease 2019 (COVID-19) is crucial for risk stratification and intervention. Kidney dysfunction contributes to... 相似文献
5.
Komiya Shiro Katsumata Mari Ozawa Moe Haze Tatsuya Kawano Rina Ohki Yuki Suzuki Shota Kobayashi Yusuke Fujiwara Akira Saka Sanae Tamura Kouichi Hirawa Nobuhito 《Clinical and experimental nephrology》2022,26(9):851-858
Clinical and Experimental Nephrology - Tolvaptan (TLV) is reported to improve diuretic effects in patients with chronic kidney disease (CKD) when furosemide (FUR) is not sufficiently effective.... 相似文献
6.
7.
[Purpose] To develop a quantitative motion analysis software specific to boxing (Fist Tactics Support) and to verify its effectiveness based on the percentage of hits that land on the participants. [Participants and Methods] A total of 24 male professional boxers were divided into two groups: those who used Fist Tactics Support to analyze fight videos and instituted training changes based on the results (Fist Tactics Support group, 12 participants) and those who did not (control group, 12 participants). The overall percentage of hits that landed on the participants in the fights was compared between the two groups and between pre- and post-intervention. [Results] There were no significant differences between the two groups; however, the percentage of hits that landed on the boxers of the Fist Tactics Support group was significantly lower at post-intervention than at pre-intervention. [Conclusion] The use of scientific analysis results in boxing may facilitate the primary prevention of sports injuries.Key words: Boxing, Development, Prevention of sports injuries 相似文献
8.
Yasutomo Fujii Nobuyuki Taniguchi Kouichi Itoh Yi Wang Kouichiro Shigeta Tomoko Ono Jing-Wen Tsao Kenji Kumasaki Takashi Itoh 《Journal of Medical Ultrasonics》2003,30(1):13-19
Purpose: To evaluate a new system for displaying processed images of liver parenchyma based on quantitative estimation of heterogeneity
by texture analysis.Methods: We measured the signal to noise ratio, one of the first-order statistics in the histogram of enveloped amplitude of radio-frequency
backscattered echoes, using a 3.75-MHz transducer with texture analysis in conjunction with a new method in which the small
ROI (region of interest) is segmented into multiple layers to minimize the influence of tissue attenuation and beam diffraction.
In our computerized system, gray-display and color-display images, two types of processed images, were produced from the visual
intensity of each small ROI, which was based on its signal to noise ratio. We studied 10 cases of normal liver, 10 cases of
fatty liver, and 10 cases of cirrhotic liver. The processed images obtained from these livers were reviewed to observe their
features and to compare their usefulness in estimating the heterogeneity of the liver parenchyma with that of conventional
B-mode images.Results: Gray-display images of cirrhotic livers appeared much blacker than the images produced from other disorders, and color-display
images of cirrhotic liver appeared much bluer or greener than the others. Rate of correct diagnosis from B-mode images was
68.3 ±6.8%; from gray-display images, 85.8±7.4%; and from color-display images, 91.7±8.2%. Rate of correct assessment from
B-mode images and gray-display images was significantly correlated (p=0.0015), as was rate of correct assessment from the
B-mode images and the color-display images (p=0.0060).Conclusion: The processed images obtained using this computerized system contributed to the correct and objective interpretation of
the heterogeneity of the liver parenchyma. 相似文献
9.
10.