全文获取类型
收费全文 | 1357782篇 |
免费 | 116209篇 |
国内免费 | 8367篇 |
专业分类
耳鼻咽喉 | 16885篇 |
儿科学 | 43200篇 |
妇产科学 | 36627篇 |
基础医学 | 185178篇 |
口腔科学 | 36696篇 |
临床医学 | 123210篇 |
内科学 | 279336篇 |
皮肤病学 | 32148篇 |
神经病学 | 111154篇 |
特种医学 | 56555篇 |
外国民族医学 | 289篇 |
外科学 | 212465篇 |
综合类 | 37715篇 |
一般理论 | 414篇 |
预防医学 | 107782篇 |
眼科学 | 28866篇 |
药学 | 96849篇 |
49篇 | |
中国医学 | 4366篇 |
肿瘤学 | 72574篇 |
出版年
2018年 | 14206篇 |
2017年 | 11640篇 |
2016年 | 13523篇 |
2015年 | 15684篇 |
2014年 | 21828篇 |
2013年 | 31430篇 |
2012年 | 38819篇 |
2011年 | 41500篇 |
2010年 | 26198篇 |
2009年 | 25385篇 |
2008年 | 37980篇 |
2007年 | 40315篇 |
2006年 | 41360篇 |
2005年 | 39660篇 |
2004年 | 37693篇 |
2003年 | 36869篇 |
2002年 | 34604篇 |
2001年 | 66682篇 |
2000年 | 68282篇 |
1999年 | 56790篇 |
1998年 | 16250篇 |
1997年 | 14519篇 |
1996年 | 15452篇 |
1995年 | 16358篇 |
1994年 | 15208篇 |
1993年 | 14160篇 |
1992年 | 47148篇 |
1991年 | 45840篇 |
1990年 | 44020篇 |
1989年 | 41847篇 |
1988年 | 38791篇 |
1987年 | 38105篇 |
1986年 | 35878篇 |
1985年 | 34649篇 |
1984年 | 26344篇 |
1983年 | 22072篇 |
1982年 | 13813篇 |
1981年 | 12408篇 |
1980年 | 11667篇 |
1979年 | 23508篇 |
1978年 | 17019篇 |
1977年 | 14323篇 |
1976年 | 13103篇 |
1975年 | 13660篇 |
1974年 | 16039篇 |
1973年 | 15360篇 |
1972年 | 14132篇 |
1971年 | 13007篇 |
1970年 | 11853篇 |
1969年 | 11082篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Tyler B. Kratzer MPH Ahmedin Jemal DVM PhD Kimberly D. Miller MPH Sarah Nash PhD Charles Wiggins PhD Diana Redwood PhD Robert Smith PhD Rebecca L. Siegel MPH 《CA: a cancer journal for clinicians》2023,73(2):120-146
American Indian and Alaska Native (AIAN) individuals are diverse culturally and geographically but share a high prevalence of chronic illness, largely because of obstacles to high-quality health care. The authors comprehensively examined cancer incidence and mortality among non-Hispanic AIAN individuals, compared with non-Hispanic White individuals for context, using population-based data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries. Overall cancer rates among AIAN individuals were 2% higher than among White individuals for incidence (2014 through 2018, confined to Purchased/Referred Care Delivery Area counties to reduce racial misclassification) but 18% higher for mortality (2015 through 2019). However, disparities varied widely by cancer type and geographic region. For example, breast and prostate cancer mortality rates are 8% and 31% higher, respectively, in AIAN individuals than in White individuals despite lower incidence and the availability of early detection tests for these cancers. The burden among AIAN individuals is highest for infection-related cancers (liver, stomach, and cervix), for kidney cancer, and for colorectal cancer among indigenous Alaskans (91.3 vs. 35.5 cases per 100,000 for White Alaskans), who have the highest rates in the world. Steep increases for early onset colorectal cancer, from 18.8 cases per 100,000 Native Alaskans aged 20–49 years during 1998 through 2002 to 34.8 cases per 100,000 during 2014 through 2018, exacerbated this disparity. Death rates for infection-related cancers (liver, stomach, and cervix), as well as kidney cancer, were approximately two-fold higher among AIAN individuals compared with White individuals. These findings highlight the need for more effective strategies to reduce the prevalence of chronic oncogenic infections and improve access to high-quality cancer screening and treatment for AIAN individuals. Mitigating the disparate burden will require expanded financial support of tribal health care as well as increased collaboration and engagement with this marginalized population. 相似文献
2.
Carlos Casas-Arozamena Cristian Pablo Moiola Ana Vilar Marta Bouso Juan Cueva Silvia Cabrera Victoria Sampayo Efigenia Arias Alicia Abalo Ángel García Ramón Manuel Lago-Lestón Sara Oltra Eva Díaz Juan Ruiz-Bañobre Rafael López-López Gema Moreno-Bueno Antonio Gil-Moreno Eva Colás Miguel Abal Laura Muinelo-Romay 《International journal of cancer. Journal international du cancer》2023,152(10):2206-2217
The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating-DNA (cfDNA) samples capture the intratumor heterogeneity and provide a more comprehensive and dynamic molecular diagnosis. Thus, MSI analysis by droplet-digital PCR (ddPCR) in UAs and cfDNA can provide a reliable tool to characterize and follow-up the disease. The UAs, paraffin-embedded tumor tissue (FFPE) and longitudinal plasma samples from a cohort of 90 EC patients were analyzed using ddPCR panel and compared to the SoC. A high concordance (96.67%) was obtained between the analysis of MSI markers in UAs and the SoC. Three discordant cases were validated as unstable by ddPCR on FFPE samples. Besides, a good overall concordance (70.27%) was obtained when comparing the performance of the ddPCR assay on UAs and cfDNA in high-risk tumors. Importantly, our results also evidenced the value of MSI analysis to monitor the disease evolution. MSI evaluation in minimally invasive samples shows great accuracy and sensitivity and provides a valuable tool for the molecular characterization and follow-up of endometrial tumors, opening new opportunities for personalized management of EC. 相似文献
3.
4.
Perkins Jessica M. Kakuhikire Bernard Baguma Charles Rasmussen Justin D. Satinsky Emily N. Kiconco Allen Kananura Justus Audet Carolyn M. Siedner Mark J. Haberer Jessica E. Bangsberg David R. Tsai Alexander C. 《AIDS and behavior》2022,26(6):1892-1904
AIDS and Behavior - Although misperceived norms often drive personal health behaviors, we do not know about this phenomenon in the context of antiretroviral therapy (ART) adherence. We conducted a... 相似文献
5.
Lee Jeesoo El Hangouche Nadia Pathrose Ashitha Soulat Gilles Barker Alex J. Thomas James D. Markl Michael 《The international journal of cardiovascular imaging》2022,38(9):2047-2056
The International Journal of Cardiovascular Imaging - This study investigated the impact of bicuspid aortic valve (BAV) on valve morphology and motion as well as proximal and aortic hemodynamics... 相似文献
6.
Sheeba M. Joseph Felix G.E. Dyrna Vivek Chadayammuri Taylor Wiley Elifho Obopilwe Bastian Scheiderer Knut Beitzel Mark P. Cote Anthony A. Romeo Augustus D. Mazzocca 《Seminars in Arthroplasty》2022,32(1):116-124
BackgroundReverse total shoulder arthroplasty (RSA) primarily varies between 2 implant design options: a 135 humeral stem inclination that closely resembles anatomic orientation, versus the Grammont-style 155 humeral stem inclination that further medializes and distalizes the center of rotation (COR). The purpose of this study was to compare deltoid force, glenoid strain, and simulated glenohumeral range of motion (ROM) between RSA 135 and RSA 155 designs, with a series of standardized permutations of glenosphere offset and rotator cuff pathology.MethodsTwelve fresh-frozen cadaveric shoulder specimens were studied using a shoulder simulator. Native shoulder motion profiles for reproducible abduction range of motion were established using a customized testing device. Optical 3-dimensional tracking and pressure sensors were used to accurately record glenohumeral range of motion (ROM), deltoid force, and glenoid strain for RSA 135 and RSA 155 designs. For each cohort, all combinations of glenosphere offsets and rotator cuff tendon involvement were evaluated.ResultsThere was no significant difference in the overall abduction ROM between the 155 and the 135 humeral stem implants (P = .75). Resting abduction angle and maximum abduction angle were significantly greater with a 155 + STD (standard offset) construct than with a 135 + STD construct (P < .001 and P = .01, respectively). Both stem inclinations decreased combined deltoid force requirements as compared the native shoulder with a massive cuff tear. Effective glenoid strain did not vary significantly between 135 + STD and 155 + STD constructs (P = .66).ConclusionOverall, range of motion between the 135 and the 155 humeral stem inclinations was not significantly different. The cumulative deltoid force was lower in RSA shoulders when compared to native shoulders with massive rotator cuff tears, highlighting the utility of both implant designs. The Grammont-style 155 stem coupled with a 2.5 mm inferior offset glenosphere required less deltoid force to reach maximum abduction than did the more anatomic, lateralized 135 stem coupled with a 4 mm lateral offset glenosphere.Level of EvidenceBasic Science, Biomechanics Controlled Laboratory Study 相似文献
8.
9.
Pieternella C. Bots-VantSpijker Claar D. van der Maarel-Wierink Jos M.G.A. Schols Josef J.M. Bruers 《International dental journal》2022,72(2):169-178
BackgroundResearch into oral health care for older people has shown that dental care in general decreases with increasing age and frailty and, therefore, oral health care provision may be complex. The aim of this study is to identify the oral health care dentists provide to community-dwelling older people and which barriers they experience in doing this.MethodsIn this cross-sectional study, a representative sample of dentists in the Netherlands was asked to prospectively select one older patient and describe this patient using a specially developed registration form; the patient was requested to fill out a questionnaire. The relationship between experienced barriers in providing oral health care to older patients and characteristics of the dentists and the patients was studied by means univariate and multivariate logistic regression analysis.ResultsIn total, 923 dentists were asked to participate in the study. Data were available for 39.4% dentist–patient pairs. In most cases (87.4%), oral health care was focussed on conservation of the dentition. In all, 14.0% of the dentists experienced barriers in providing oral health care for older people. Some patient factors increase the risk of experiencing barriers, eg, the more difficult behaviour of older patients and the greater disease burden.ConclusionsOral health care was mostly focussed on conservation of the dentition, and dentists especially experience barriers in oral health provision to older patients if they are already frail. 相似文献
10.
Avila Viviana Díaz-Báez David Beltrán Edgar O. Castellanos Jaime Martignon Stefania 《Clinical oral investigations》2022,26(4):3573-3584
Clinical Oral Investigations - To validate a questionnaire for the identification of factors associated with erosive tooth wear (ETW) in adolescents. Based on previous questionnaires, a 73-question... 相似文献