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排序方式: 共有1476条查询结果,搜索用时 46 毫秒
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Kohei Yamaguchi Tomomoto Ishikawa Shimpei Mizuta Takumi Takeuchi Hidehiko Matsubayashi Shoji Kokeguchi Toshihiro Habara Kentaro Ichioka Masakazu Ohashi Sumihide Okamoto Toshihiro Kawamura Satoru Kanto Hisanori Taniguchi Fumiko Tawara Tetsuaki Hara Hatsuki Hibi Hiroshi Masuda Takehiko Matsuyama Hiroaki Yoshida 《Reproductive Medicine and Biology》2020,19(2):158-163
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Akihiro Hoshino Xi Yang Kay Tanita Kenichi Yoshida Toshiaki Ono Naonori Nishida Yusuke Okuno Takeyuki Kanzaki Kumiko Goi Hisanori Fujino Koichi Ohshima Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Satoru Miyano Seishi Ogawa Seiji Kojima Tomohiro Morio Hirokazu Kanegane 《The Journal of allergy and clinical immunology》2019,143(1):421-424.e11
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Hisanori Isomura Ayumu Taguchi Taisuke Kajino Naoya Asai Masahiro Nakatochi Seiichi Kato Keiko Suzuki Kiyoshi Yanagisawa Motoshi Suzuki Teruaki Fujishita Tomoya Yamaguchi Masahide Takahashi Takashi Takahashi 《Cancer science》2021,112(4):1614-1623
We previously reported that ROR1 is a crucial downstream gene for the TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indicates ROR1 as an attractive molecular target, though it has yet to be determined whether targeting Ror1 can inhibit tumor development and growth in vivo. To this end, genetically engineered mice carrying homozygously floxed Ror1 alleles and an SP-C promoter–driven human mutant EGFR transgene were generated. Ror1 ablation resulted in marked retardation of tumor development and progression in association with reduced malignant characteristics and significantly better survival. Interestingly, gene set enrichment analysis identified a hypoxia-induced gene set (HALLMARK_HYPOXIA) as most significantly downregulated by Ror1 ablation in vivo, which led to findings showing that ROR1 knockdown diminished HIF-1α expression under normoxia and clearly hampered HIF-1α induction in response to hypoxia in human lung adenocarcinoma cell lines. The present results directly demonstrate the importance of Ror1 for in vivo development and progression of lung adenocarcinoma, and also identify Ror1 as a novel regulator of Hif-1α. Thus, a future study aimed at the development of a novel therapeutic targeting ROR1 for treatment of solid tumors such as seen in lung cancer, which are frequently accompanied with a hypoxic tumor microenvironment, is warranted. 相似文献
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Quantitation of basal dyssynchrony and acute resynchronization from left or biventricular pacing by novel echo-contrast variability imaging 总被引:4,自引:0,他引:4
Kawaguchi M Murabayashi T Fetics BJ Nelson GS Samejima H Nevo E Kass DA 《Journal of the American College of Cardiology》2002,39(12):2052-2058
OBJECTIVES: This study sought to test a novel echocardiographic method based on contrast variability imaging (CVI), to quantify cardiac dyssynchrony and magnitude of resynchronization achieved by left ventricular (LV) and biventricular (BiV) pacing therapy. BACKGROUND: Left ventricular or BiV pacing is a promising new therapy for patients with heart failure and intraventricular conduction delay. However, precise quantitation of the extent of resynchronization achieved remains scant. METHODS: Ten patients treated with BiV or LV pacing therapy were studied. Echo-contrast was infused slowly, and gated images were acquired before and during contrast appearance. The temporally normalized variance derived from 30 to 50 sequential beats was determined at each pixel to yield the CVI image-displaying improved wall delineation. Systolic regional fractional area of radial sectors was calculated with active and temporarily suspended (AAI) pacing. All analyses were performed blinded to both patient and treatment. RESULTS: Pacing increased septal inward motion from -20.4 +/- 9.6% to -30.5 +/- 14.0%, whereas lateral wall motion occurred earlier with no net magnitude change. Both spatial and temporal dyssynchrony in the LV declined nearly 40% with LV or BiV pacing (p < or = 0.001), and this correlated with increasing ejection fraction (31% to 39%; p < 0.02; p < 0.004 for correlation with dyssynchrony). CONCLUSIONS: The new imaging and regional dyssynchrony analysis methods provide quantitative assessment of resynchronization analogous to that previously obtained only by tagged magnetic resonance imaging. This could provide a useful noninvasive method for both identifying candidates and following long-term therapy. 相似文献