全文获取类型
收费全文 | 2571篇 |
免费 | 182篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 36篇 |
妇产科学 | 17篇 |
基础医学 | 266篇 |
口腔科学 | 28篇 |
临床医学 | 160篇 |
内科学 | 828篇 |
皮肤病学 | 27篇 |
神经病学 | 202篇 |
特种医学 | 78篇 |
外科学 | 503篇 |
综合类 | 26篇 |
一般理论 | 2篇 |
预防医学 | 43篇 |
眼科学 | 31篇 |
药学 | 130篇 |
中国医学 | 2篇 |
肿瘤学 | 361篇 |
出版年
2023年 | 30篇 |
2022年 | 26篇 |
2021年 | 96篇 |
2020年 | 49篇 |
2019年 | 69篇 |
2018年 | 92篇 |
2017年 | 79篇 |
2016年 | 91篇 |
2015年 | 116篇 |
2014年 | 109篇 |
2013年 | 127篇 |
2012年 | 203篇 |
2011年 | 210篇 |
2010年 | 110篇 |
2009年 | 99篇 |
2008年 | 162篇 |
2007年 | 200篇 |
2006年 | 143篇 |
2005年 | 157篇 |
2004年 | 148篇 |
2003年 | 117篇 |
2002年 | 127篇 |
2001年 | 22篇 |
2000年 | 11篇 |
1999年 | 26篇 |
1998年 | 22篇 |
1997年 | 22篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 11篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1986年 | 3篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1965年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有2782条查询结果,搜索用时 78 毫秒
1.
2.
3.
Tadashi Nomura MD PhD Mika Nakasone MD Takako Okamoto MD Hirotaka Ejiri MD PhD Sayuri Osawa MD Kazunobu Hashikawa MD PhD Hiroto Terashi MD PhD 《Pediatric dermatology》2020,37(4):776-779
Infantile hemangioma (IH) is a benign vascular tumor that gradually involutes over several years. Rapidly involuting congenital hemangioma (RICH) is the relatively rare congenital vascular tumor that is fully grown at birth and does not undergo postnatal growth and involutes during the first year. However, after involution of both IH and RICH, some have severe sequelae, such as redundant skin or conspicuous scarring, requiring additional treatment. We present the case of a 6-year-old girl with a concave deformity due to subcutaneous atrophy, skin darkening, and altered skin texture of her left zygomatic region following involution of a hemangioma. We successfully treated this patient by transferring a dermal fat graft. This technique can be beneficial for atrophic sequelae after regression of a hemangioma and is easy to perform and cosmetically effective. 相似文献
4.
Tetsuro Ohba Hiroki Oba Kensuke Koyama Kotaro Oda Nobuki Tanaka Koji Fujita Hirotaka Haro 《Journal of orthopaedic science》2021,26(4):678-683
BackgroundLocomotive syndrome (LS) was proposed by the Japanese Orthopedic Association and refers to a scenario in which imminent future nursing care services will be required by elderly adults to manage the functional deterioration of their locomotive organs. It is a social imperative to clarify the risk factors and treatment strategy for LS. However, the relationship between LS and adult spinal deformity (ASD) in those who are treated with spinal corrective surgery remains largely unknown.MethodsForty consecutive patients who had ASD and underwent spinal surgery for their disorder were included in this study. Locomotive dysfunction was evaluated using the 25-item Geriatric Locomotive Function Scale-25 (GLFS-25) questionnaire and physical performance tests including the one-legged standing test, the two-step test, the stand-up test, the handgrip strength, and gait speed test which were measured preoperatively, 6 months after surgery, and 1 year after surgery.ResultsOf the patients with ASD treated surgically, 95% of them had LS preoperatively and LS prevalence decreased significantly 1 year after surgery by 67.5% compared with the preoperative rate. Among physical performance tests, the walking stride and one-legged standing test improved significantly after spinal corrective surgery. The GLFS-25 items for the domains of pain, mobility, and domestic life improved overall postoperatively, whereas items in the self-care domain did not and the item for difficulty in putting on and taking off trousers and pants worsened.ConclusionsSpinal corrective surgery significantly improved physical performance tests as well as the frequency and severity of LS in patients with ASD. However, some GLFS-25 items can worsen after surgery and require attention. 相似文献
5.
6.
Kei Minowa Katsuhiro Arai Mureo Kasahara Seisuke Sakamoto Hirotaka Shimizu Natsuko Nakano Reiko Ito Naho Obayashi Atsuko Nakazawa Akira Ishiguro 《Pediatric transplantation》2014,18(6):E212-E215
Thrombocytopenia is a major risk factor for cirrhotic liver disease. Patients with thrombocytopenia may have esophageal or gastric varices secondary to portal hypertension, leading to variceal bleeding which exposes the liver to further damage. Here, we present a female pediatric patient with PSC and CD, whose progressive thrombocytopenia was successfully controlled by romiplostim, a TPO receptor agonist. The patient developed bloody diarrhea at four yr of age, and was subsequently diagnosed with PSC and CD when seven yr old. While CD was well‐controlled by immunomodulators, the patient's thrombocytopenia gradually progressed resulting in petechiae (platelet count of 11 × 109/L) when she was 10 yr and four months old. She responded poorly to immunoglobulin and corticosteroids. Weekly subcutaneous injection of romiplostim was therefore initiated, and platelet counts were maintained over at 50 × 109/L. She was able to undergo successful LDLT without platelet transfusion seven months after the initiation of romiplostim. Romiplostim was not required after LDLT with improved platelet counts. This case report suggests that romiplostim may be effective in the treatment of thrombocytopenic children with liver cirrhosis and portal hypertension, and in eliminating the need for platelet transfusion during the peri‐transplant period. 相似文献
7.
Kikuchi N Kitamura C Morotomi T Inuyama Y Ishimatsu H Tabata Y Nishihara T Terashita M 《Journal of endodontics》2007,33(10):1198-1202
The induction of dentin formation on exposed dental pulp is a major challenge in research on the regeneration of the dentin-pulp complex. We examined the effects of fibroblast growth factor 2 (FGF2), which was delivered in either a collagen sponge (noncontrolled release) or incorporated into gelatin hydrogels (controlled release), on the formation of dentin in exposed rat molar pulps. During the early phase of pulp wound healing, pulp cell proliferation and invasion of vessels into dentin defects above exposed pulp were induced in both groups. In the late phase, the induction of dentin formation was distinctly different between the 2 types of FGF2 release. The noncontrolled release of free FGF2 from collagen sponge induced excessive reparative dentin formation in the residual dental pulp, although dentin defects were not noted. In contrast, controlled release of FGF2 from gelatin hydrogels induced the formation of dentin-like particles with dentin defects above exposed pulp. These results suggest the possibility of a novel therapeutic approach for dentin-pulp complex by controlled release of bioactive FGF2. 相似文献
8.
Kato Shunji Shiozaki Atsushi Kudou Michihiro Shimizu Hiroki Kosuga Toshiyuki Ohashi Takuma Arita Tomohiro Konishi Hirotaka Komatsu Shuhei Kubota Takeshi Fujiwara Hitoshi Okamoto Kazuma Kishimoto Mitsuo Konishi Eiichi Otsuji Eigo 《Annals of surgical oncology》2022,29(5):2944-2956
Annals of Surgical Oncology - Transient receptor potential vanilloid 2 (TRPV2) is a highly Ca2+-permeable ion channel that is involved in a number of cellular processes. It is expressed in various... 相似文献
9.
Nuclear inverse polarity papillary lesions lacking myoepithelial cells: A report of two cases 下载免费PDF全文
Shinya Tajima Ichiro Maeda Yoshio Aida Akio Kazama Hirotaka Koizumi Masatomo Doi Akira Endo Motohiro Chosokabe Keiko Kishimoto Takafumi Ono Koichiro Tsugawa Masayuki Takagi 《Pathology international》2018,68(1):36-40
Here, cases of a 68‐ (Case 1) and a 44‐year‐old (Case 2) female are presented. They had an abnormality in the breast, and came to our hospital for further examination and treatment. Radiologically, malignancy could not completely excluded so breast excision was performed. Histologically, both cases revealed papillary neoplastic lesions lined by fibrovascular core and nuclear inverse polarity without atypia. Loss of myoepithelial cells was observed by HE, p63, and calponin. Previous report indicate CK5/6, ER, p63 and MUC3 are important for distinguishing between papillary lesions according to the differential index (based on Allred score) of ([ER total score] + [MUC3 total score])/([CK5/6 total score] + [p63 total score] + 1). Based on this analysis, our two cases had benign lesions. However, based on immunopositivity for cell‐cycle marker Cyclin‐D1, Case 1 was negative, and Case 2 was about 70% positive. Additionally, the Ki‐67 index was <1% in both cases, and no evidence of disease was observed after a maximum 62 months of follow‐up in both cases, despite lack of additional treatment. Thus, we propose that lack of myoepithelial cells in papillary lesions do not necessarily indicate malignancy and are thought to be, at the most, uncertain malignant potential. 相似文献
10.