全文获取类型
收费全文 | 7556篇 |
免费 | 674篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 209篇 |
妇产科学 | 106篇 |
基础医学 | 891篇 |
口腔科学 | 163篇 |
临床医学 | 850篇 |
内科学 | 1517篇 |
皮肤病学 | 104篇 |
神经病学 | 432篇 |
特种医学 | 469篇 |
外科学 | 1037篇 |
综合类 | 176篇 |
一般理论 | 1篇 |
预防医学 | 850篇 |
眼科学 | 97篇 |
药学 | 588篇 |
中国医学 | 4篇 |
肿瘤学 | 700篇 |
出版年
2023年 | 45篇 |
2021年 | 93篇 |
2020年 | 72篇 |
2019年 | 106篇 |
2018年 | 137篇 |
2017年 | 106篇 |
2016年 | 127篇 |
2015年 | 120篇 |
2014年 | 178篇 |
2013年 | 260篇 |
2012年 | 357篇 |
2011年 | 345篇 |
2010年 | 228篇 |
2009年 | 189篇 |
2008年 | 325篇 |
2007年 | 369篇 |
2006年 | 333篇 |
2005年 | 290篇 |
2004年 | 302篇 |
2003年 | 267篇 |
2002年 | 268篇 |
2001年 | 267篇 |
2000年 | 281篇 |
1999年 | 205篇 |
1998年 | 104篇 |
1997年 | 91篇 |
1996年 | 93篇 |
1995年 | 101篇 |
1994年 | 84篇 |
1993年 | 80篇 |
1992年 | 184篇 |
1991年 | 168篇 |
1990年 | 161篇 |
1989年 | 147篇 |
1988年 | 183篇 |
1987年 | 151篇 |
1986年 | 121篇 |
1985年 | 140篇 |
1984年 | 104篇 |
1983年 | 102篇 |
1982年 | 63篇 |
1981年 | 60篇 |
1980年 | 43篇 |
1979年 | 93篇 |
1978年 | 71篇 |
1977年 | 53篇 |
1976年 | 54篇 |
1974年 | 55篇 |
1973年 | 64篇 |
1970年 | 43篇 |
排序方式: 共有8248条查询结果,搜索用时 15 毫秒
1.
2.
M. L. Eckstein D. M. Williams L. K. O'Neil J. Hayes J. W. Stephens R. M. Bracken 《Diabetic medicine》2019,36(3):349-358
In the UK the National Institute of Health and Care Excellence (NICE) advocates intensive lifestyle programmes that attain the levels of daily physical activity set out by the Chief Medical Officer as a first‐line strategy for improving the health of people at risk of developing diabetes or reducing the risk of development of Type 2 diabetes. For people with Type 2 diabetes, lifestyle measures complement pharmacological treatments that include both oral and injectable therapies. In line with this, NICE guidelines also support intensification of efforts to improve patient lifestyle along with these glucose‐lowering therapies. There is a paucity of evidence, however, in the available published literature examining the association between glucose‐lowering therapies and exercise metabolism. In the present review we explore the current knowledge with regard to the potential interactions of oral and non‐insulin injectable therapies with physical activity in people at risk of, or who have, Type 2 diabetes, and present evidence that may inform healthcare professionals of the need to monitor patients more closely in their adaptation to both pharmacological therapy and physical activity. 相似文献
3.
4.
5.
Ian RP Sunderland Glenn Edwards James Mainprize Oleh Antonyshyn 《CANADIAN JOURNAL OF PLASTIC SURGERY》2015,23(2):95-99
Prefabricated, patient-specific alloplastic implants for cranioplasty reduce surgical complexity, decrease operative times, minimize exposure and risk of contamination, and have resulted in improved aesthetic results. However, in creating a prefabricated custom implant using a patient’s computed tomography data, a stable, unalterable defect must be clearly defined before surgery. In the event that an intraoperative modification of an exiting skull defect is required, or in cases of tumour resection in which the size of the skull defect is unknown preoperatively, these prefabricated implants cannot be used. The ideal method for alloplastic cranioplasty would enable cost-effective creation of a patient-specific implant with the capacity for intraoperative modification.The present article describes a novel technique of cranioplasty that uses a patient’s computed tomography data to create a custom forming tool (ie, mold), enabling intraoperative creation of a patient-specific titanium mesh implant. The utility of these implants in creating a custom reconstructive solution in cases in which the size of the skull defect is unknown preoperatively will be demonstrated using two case presentations. 相似文献
6.
Junguk Hur Jacqueline R. Dauch Lucy M. Hinder John M. Hayes Carey Backus Subramaniam Pennathur Matthias Kretzler Frank C. Brosius III Eva L. Feldman 《Diabetes》2015,64(9):3294-3304
To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db mice produced a significant weight gain, restored glycemic control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN. 相似文献
7.
Impact of induction immunosuppression on survival in heart transplant recipients: a contemporary analysis of agents 下载免费PDF全文
8.
9.
10.
Comparison of cold lateral condensation and a warm multiphase gutta-percha technique for obturating curved root canals 总被引:1,自引:0,他引:1
AIM: The aim of this project was to evaluate and compare the radiographic quality and sealability of root fillings in extracted human teeth using lateral condensation of gutta-percha or multiphase gutta-percha obturation (Alphaseal). METHODOLOGY: A total of 108 freshly extracted human, mature single-rooted teeth were divided into two identical groups of 54 teeth on the basis of root canal shape. The canals were prepared to a minimum 0.055 taper and enlarged to size 35 at the apex. All root canals were flushed with 17% EDTA solution and 2.5% NaOCl to remove the dentinal smear layer. The canals of one group were obturated using cold lateral condensation of gutta-percha and the canals of the other group were filled using a warm multiphase gutta-percha obturation technique. The extrusion of sealer and/or gutta-percha through the apex of the teeth was recorded using a simple yes/no scheme. The sealability of each technique was assessed by a dye penetration method. The radiographic quality of obturation was determined for each canal using a four-point scale. RESULTS: Root canals filled by multiphase obturation had significantly more extrusion of sealer (P < 0.001) and gutta-percha (P < 0.001) than canals filled by lateral condensation. Canals filled by multiphase gutta-percha obturation had significantly less apical dye leakage than those obturated by lateral condensation (P < 0.05). Lateral condensation achieved significantly better scores for radiographic quality than multiphase obturation from the bucco-lingual view (P < 0.01). CONCLUSIONS: Under laboratory conditions multiphase gutta-percha had better sealability but poorer radiographic quality than lateral condensation. 相似文献