全文获取类型
收费全文 | 19740篇 |
免费 | 1321篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 236篇 |
儿科学 | 579篇 |
妇产科学 | 348篇 |
基础医学 | 2918篇 |
口腔科学 | 519篇 |
临床医学 | 1856篇 |
内科学 | 3628篇 |
皮肤病学 | 351篇 |
神经病学 | 1859篇 |
特种医学 | 993篇 |
外国民族医学 | 25篇 |
外科学 | 2451篇 |
综合类 | 158篇 |
一般理论 | 13篇 |
预防医学 | 2100篇 |
眼科学 | 217篇 |
药学 | 1684篇 |
中国医学 | 58篇 |
肿瘤学 | 1115篇 |
出版年
2021年 | 262篇 |
2020年 | 191篇 |
2019年 | 263篇 |
2018年 | 339篇 |
2017年 | 259篇 |
2016年 | 312篇 |
2015年 | 355篇 |
2014年 | 450篇 |
2013年 | 638篇 |
2012年 | 934篇 |
2011年 | 979篇 |
2010年 | 560篇 |
2009年 | 537篇 |
2008年 | 919篇 |
2007年 | 917篇 |
2006年 | 898篇 |
2005年 | 873篇 |
2004年 | 811篇 |
2003年 | 787篇 |
2002年 | 748篇 |
2001年 | 578篇 |
2000年 | 598篇 |
1999年 | 511篇 |
1998年 | 204篇 |
1997年 | 159篇 |
1996年 | 128篇 |
1995年 | 165篇 |
1994年 | 203篇 |
1993年 | 263篇 |
1992年 | 593篇 |
1991年 | 551篇 |
1990年 | 451篇 |
1989年 | 302篇 |
1988年 | 291篇 |
1987年 | 281篇 |
1986年 | 234篇 |
1985年 | 282篇 |
1984年 | 211篇 |
1983年 | 155篇 |
1982年 | 129篇 |
1981年 | 127篇 |
1979年 | 172篇 |
1978年 | 139篇 |
1977年 | 128篇 |
1976年 | 144篇 |
1975年 | 146篇 |
1974年 | 187篇 |
1973年 | 159篇 |
1971年 | 139篇 |
1970年 | 126篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
1.
2.
Oliver Sartor MD Daniel Heinrich MD Neil Mariados MD Maria José Méndez Vidal MD Daniel Keizman MD Camilla Thellenberg Karlsson MD Avivit Peer MD Giuseppe Procopio MD Stephen J. Frank MD Kalevi Pulkkanen MD Eli Rosenbaum MD Stefano Severi MD José Trigo MD Lucia Trandafir MD Volker Wagner MD Rui Li MS Luke T. Nordquist MD 《The Prostate》2019,79(14):1683-1691
3.
4.
5.
A.S. Tjalsma A. Wagner W.N.M. Dinjens P.C. Ewing-Graham L.S.M. Alcalá M.E.R. de Groot K.E. Hamoen A.C. van Hof W. Hofhuis L.N. Hofman K.J. Hoogduin J. Kaijser A.C.F. Makkus S.J.J. Mol G.M. Plaisier K. Schelfhout H.P.M. Smedts R.A. Smit H.C. van Doorn 《Gynecologic oncology》2021,160(3):771-776
ObjectiveIn the Netherlands a nationwide guideline was introduced in 2016, which recommended routine Lynch syndrome screening (LSS) for all women with endometrial cancer (EC) <70 years of age. LSS consists of immunohistochemical (IHC) staining for loss of mismatch repair (MMR) protein expression, supplemented with MLH1 methylation analysis if indicated. Test results are evaluated by the treating gynaecologist, who refers eligible patients to a clinical geneticist. We evaluated the implementation of this guideline.MethodsFrom the nation-wide pathology database we selected all women diagnosed with EC < 70 years of age, treated from 1.6.2016–1.6.2017 in 14 hospitals. We collected data on the results of LSS and follow up of cases with suspected LS.ResultsIn 183 out of 204 tumours (90%) LSS was performed. In 41 cases (22%) MMR protein expression was lost, in 25 cases due to hypermethylation of the MLH1 promotor. One patient was known with a pathogenic MLH1 variant. The option of genetic counselling was discussed with 12 of the 15 remaining patients, of whom three declined. After counselling by the genetic counsellor nine patients underwent germline testing. In two no pathogenic germline variant was detected, two were diagnosed with a pathogenic PMS2 variant, and five with a pathogenic MSH6 variant, in concordance with the IHC profiles.ConclusionCoverage of LSS was high (90%), though referral for genetic counselling could be improved. Gynaecologists ought to be aware of the benefits and possible drawbacks of knowing mutational status, and require training in discussing this with their patients. 相似文献
6.
7.
8.
Benedikt W. Burkhardt Andreas Simgen Matthias Dehnen Gudrun Wagenpfeil Wolfgang Reith Joachim M. Oertel 《The spine journal》2019,19(4):587-596
BACKGROUND CONTEXT
Anterior cervical discectomy and fusion (ACDF) without and with cervical plating (ACDF+CP) are accepted surgical techniques for the treatment of degenerative cervical disc disorders. The effect of CP on the development of adjacent segment degeneration (ASD) remains unclear.PURPOSE
To assess whether CP accelerates the degeneration of the adjacent and adjoining segments.STUDY DESIGN/SETTING
This is an imaging cohort study.PATIENT SAMPLE
Retrospectively, a total of 84 patients who underwent ACDF or ACDF+CP were identified. At final follow-up, an MRI was performed and evaluated in this study.MATERIALS AND METHODS
An MRI of 84 patients who underwent ACDF (46 patients) and ACDF+PS (38 patients) was performed. The mean follow-up was 24 years (17–45 years). None of the patients had a repeat procedure in the cervical spine. The grade of degeneration of the segments adjacent and adjoining to the fusion was assessed via a five-step grading system (segmental degeneration index, or SDI) that includes disc signal intensity, anterior and posterior disc protrusion, narrowing of the disc space, and foraminal stenosis. Furthermore, the disc height (DH) and sagittal segmental angle (SSA) of fused segments were measured.RESULTS
A significantly (p<.001) greater SDI was identified at the caudal adjacent segment following ACDF compared to ACDF+CP. No other significant differences were identified in patients following ACDF and ACDF+CP. Between 50% and 96% of all segments showed severe degenerative changes according to SDI. There was no significant difference in DH between the patients following ACDF and ACDF+CP. The SSA in patients who underwent ACDF+CP was significantly greater than in the ACDF patients (p=.002).CONCLUSIONS
In this cohort of patients, cervical plating had no significant impact on segmental degeneration and decrease of DH in the adjacent and adjoining segments. ACDF+CP seem to preserve the lordotic alignment more with respect to the SSA than ACDF. 相似文献9.
10.
Brenda Laky Isabella Alram Julia K. Frank Leo Pauzenberger Werner Anderl Karl-Heinz Wagner Philipp R. Heuberer 《Journal of orthopaedic research》2020,38(9):2074-2082
Increasing numbers of arthroplasties are also accompanied by postoperative infections. The main purpose was to evaluate preoperative serum bilirubin levels between patients with and without infections after shoulder and knee arthroplasties. For this retrospective case-control single-center study, a total of 108 patients were extracted from a prospectively collected database. Eighteen patients with infections after shoulder (n = 8) and knee (n = 10) arthroplasty were matched by age, gender, and implant type in a 1:5-scenario to 90 patients (40 shoulders and 50 knees) without postoperative infection. Demographic data, preoperative blood parameters, and postoperative infection-related outcomes were evaluated. Total bilirubin was the only preoperative parameter significantly different between the infection (8.21 ± 3.25 μmol/L or 0.48 ± 0.19 mg/dL) and noninfection (10.78 ± 4.62 μmol/L or 0.63 ± 0.27 mg/dL; P = .014) group, while C-reactive protein and other liver parameters were similar between the groups. Significantly more controls (92.1%) had preoperative bilirubin levels above 8.72 μmol/L or 0.51 mg/dL than cases (7.9%; P = .007). The 5-year infection survival-rate was 65.6% for patients with preoperative bilirubin levels < 8.72 μmol/L or < 0.51 mg/dL and 91.2% with ≥ 8.72 μmol/L or ≥ 0.51 mg/dL. Mildly decreased preoperative bilirubin levels with a cutoff at 8.72 μmol/L or 0.51 mg/dL were significantly associated to patients with infections after shoulder and knee arthroplasty. There were no differences in other blood parameters or comorbidities between patients with infections and their matched-controls. 相似文献