排序方式: 共有15条查询结果,搜索用时 15 毫秒
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David Emmanuelle Fauvernier Mathieu Saadoun David Gerfaud-Valentin Mathieu Maurcort-Boulch Delphine Sève Pascal Jamilloux Yvan 《Clinical rheumatology》2022,41(6):1749-1758
Clinical Rheumatology - To examine the mortality rates and causes of death among French decedents with Behçet’s disease (BD). Data collected between 1979 and 2016 by the French... 相似文献
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E. Peter F. Jean-Baptiste B. Harbaoui I. Kone-Paut C. Dauphin E. Gomard-Mennesson B. Hervier H. De Boysson L. Varron G. Pugnet D. Gobert C. Bachmeyer S. Humbert P. Roblot P. Cathébras M. Gerfaud-Valentin E. Weber Y. Jamilloux P. Sève 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2021
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Y. Jamilloux C. Bernard O. Lortholary S. Kerever L. Lelièvre M. Gerfaud-Valentin C. Broussolle D. Valeyre P. Sève 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2017,38(5):320-327
Opportunistic infections (OI) are uncommon in sarcoidosis (1 to 10%) and mostly occur in patients with previously diagnosed disease or can rarely be the presenting manifestation. The most common OIs are, in descending order: aspergillosis, cryptococcosis, and mycobacterial infections. Treatment with corticosteroids is the most frequent risk factor for OI occurrence during sarcoidosis but immunosuppressive drugs and therapy with anti-TNFα are also risk factors. Overall, clinical presentation, treatment, and outcome are identical to that occur in other conditions complicated with the occurrence of OIs. However, some atypical presentations of OIs can mimic sarcoidosis exacerbation and misdiagnosis may lead clinicians to increase immunosuppression, causing worsening of the OI. The meticulous collection of patient's history along with factors differentiating OI from sarcoidosis exacerbation is key factor to optimally manage these patients. 相似文献
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Y. Jamilloux E. Bourdonnay M. Gerfaud-Valentin B.F. Py L. Lefeuvre T. Barba C. Broussolle T. Henry P. Sève 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2018,39(4):233-239
Interleukin-1 is a major cytokine of innate immunity and inflammation. It exerts various systemic effects during the inflammatory response, such as fever induction, thrombopoiesis and granulopoiesis, or leukocyte recruitment. Its involvement has been demonstrated in many inflammatory-mediated diseases, such as diabetes or gout. Moreover, interleukin-1 plays a pivotal role in some autoinflammatory diseases, such as cryopyrinopathies or familial Mediterranean fever. In these diseases, a constitutional defect of the inflammasome, a protein complex responsible for the activation of interleukin-1, explains the hypersecretion of interleukin-1. Other autoinflammatory diseases have a more complex pathophysiology involving deregulation of the interleukin-1 pathway, upstream or downstream of the inflammasome, or through more complex mechanisms. In this review, we are detailing the synthesis, the activation, the signalling, and the regulation of interleukin-1. We then describe the autoinflammatory diseases or related-diseases where the pathological role of interleukin-1 has been demonstrated. 相似文献
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N. Senni M. Gerfaud-Valentin A. Hot C. Huissoud P. Gaucherand J. Tebib C. Broussolle Y. Jamilloux P. Sève 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2021,42(6):375-383
IntroductionSpontaneous adrenal hemorrhages (AH) are a rare condition with no consensus about their management.MethodsPatients were identified using the Medicalization of the Information System Program database, imaging software and a call for observations to internists, intensivists and obsetricians working at our institution. Adult patients whose medical records were complete and whose diagnosis was confirmed by medical imaging were included.ResultsFrom 2000 to 2007, 20 patients were identified, including 15 were women. The clinical onset of AH was non-specific. In five cases, AH occurred during pregnancy; four of them were unilateral and right sided. The etiology of the other fifteen (bilateral adrenal hemorrhage in 11) were as follows: antiphospholipid syndrome (n = 8), heparin-induced thrombocytopenia (n = 4), essential thrombocythemia (n = 3), spontaneous AH due to oral anticoagulants (n = 1), complication of a surgical act (n = 3), and sepsis (n = 3). In seven cases, two causes were concomitant. The diagnosis of AH was often confirmed by abdominal CT. An anticoagulant treatment was initiated in 16 cases. Ten of the eleven patients presenting with bilateral adrenal hematomas were treated using a long-term substitute opotherapy. One patient died because of a catastrophic antiphospholipid syndrome.ConclusionThe clinical onset of HS is heterogeneous and non-specific. The confirmatory diagnosis is often based on abdominal CT. The search for an underlying acquired thrombophilia is essential and we found in this study etiological data comparable to the main series in the literature. Adrenal insufficiency is most of the time definitive in cases of bilateral involvement. 相似文献
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Elise Peter Jean-Baptiste Fraison Brahim Harbaoui Isabelle Koné-Paut Claire Dauphin Emeline Gomard-Mennesson Baptiste Hervier Hubert De Boysson Loig Varron Jérémy Keraen Grégory Pugnet Delphine Gobert Claude Bachmeyer Sébastien Humbert Cédric Landron Pascal Roblot Pascal Cathébras Mathieu Gerfaud-Valentin Pascal Seve 《Autoimmunity reviews》2021,20(9):102886
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Etienne Crickx Mikael Ebbo Etienne Rivière Odile Souchaud-Debouverie Louis Terriou Sylvain Audia Marc Ruivard Bouchra Asli Jean-Pierre Marolleau Nadine Méaux-Ruault Mathieu Gerfaud-Valentin Philippe Audeguy Mohamed Hamidou Selim Corm Xavier Delbrel Jean Fontan Delphine Lebon Christelle Mausservey Guillaume Moulis Nicolas Limal Marc Michel Bertrand Godeau Matthieu Mahévas 《British journal of haematology》2023,202(4):883-889
Combining drugs could be an effective option for treating multirefractory ITP, that is, patients not responding to rituximab, thrombopoietin receptor agonists (TPO-RA) and splenectomy. We conducted a retrospective, multicenter, observational study including multirefractory ITP patients who received a combination of a TPO-RA and an immunosuppressive drug. We included 39 patients (67% women, median age 59 years [range 21–96]), with a median ITP duration of 57 months [3–393] and a median platelet count at initiation of 10 × 109/L [1–35]. The combination regimen was given for a median duration of 12 months [1–103] and included eltrombopag (51%) or romiplostim (49%), associated with mycophenolate mofetil (54%), azathioprine (36%), cyclophosphamide (5%), cyclosporin (3%) or everolimus (3%). Overall, 30 patients (77%) achieved at least a response (platelet count ≥30 × 109/L and at least doubling baseline during at least 3 months), including 24 complete responses (platelet count >100 × 109/L during at least 3 months) with a median time to response of 30 days [7–270] and a median duration of response of 15 months [4–63]. Severe adverse event related to ITP treatment was observed in 31%. In conclusion, this study confirms that some patients with multirefractory ITP can achieve long lasting response with this combination. 相似文献