全文获取类型
收费全文 | 7917篇 |
免费 | 455篇 |
国内免费 | 59篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 226篇 |
妇产科学 | 190篇 |
基础医学 | 1149篇 |
口腔科学 | 197篇 |
临床医学 | 639篇 |
内科学 | 1835篇 |
皮肤病学 | 178篇 |
神经病学 | 920篇 |
特种医学 | 399篇 |
外科学 | 902篇 |
综合类 | 36篇 |
预防医学 | 369篇 |
眼科学 | 171篇 |
药学 | 527篇 |
中国医学 | 38篇 |
肿瘤学 | 596篇 |
出版年
2023年 | 76篇 |
2022年 | 71篇 |
2021年 | 207篇 |
2020年 | 136篇 |
2019年 | 188篇 |
2018年 | 243篇 |
2017年 | 180篇 |
2016年 | 196篇 |
2015年 | 236篇 |
2014年 | 283篇 |
2013年 | 352篇 |
2012年 | 561篇 |
2011年 | 583篇 |
2010年 | 351篇 |
2009年 | 326篇 |
2008年 | 522篇 |
2007年 | 539篇 |
2006年 | 548篇 |
2005年 | 495篇 |
2004年 | 496篇 |
2003年 | 484篇 |
2002年 | 410篇 |
2001年 | 89篇 |
2000年 | 67篇 |
1999年 | 93篇 |
1998年 | 73篇 |
1997年 | 63篇 |
1996年 | 50篇 |
1995年 | 44篇 |
1994年 | 30篇 |
1993年 | 39篇 |
1992年 | 31篇 |
1991年 | 30篇 |
1990年 | 30篇 |
1989年 | 39篇 |
1988年 | 42篇 |
1987年 | 28篇 |
1986年 | 24篇 |
1985年 | 13篇 |
1984年 | 17篇 |
1983年 | 17篇 |
1982年 | 16篇 |
1981年 | 9篇 |
1979年 | 15篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1974年 | 8篇 |
1970年 | 10篇 |
1969年 | 5篇 |
1967年 | 7篇 |
排序方式: 共有8431条查询结果,搜索用时 15 毫秒
1.
Rolf Svedjeholm Gabriele Ferrari Farkas Vanky Örjan Friberg Jonas Holm 《Acta anaesthesiologica Scandinavica》2023,67(10):1373-1382
Background
Glutamate plays a key role for post-ischaemic recovery of myocardial metabolism. According to post hoc analyses of the two GLUTAMICS trials, patients without diabetes benefit from glutamate with less myocardial dysfunction after coronary artery bypass surgery (CABG). Copeptin reflects activation of the Arginine Vasopressin system and is a reliable marker of heart failure but available studies in cardiac surgery are limited. We investigated whether glutamate infusion is associated with reduced postoperative rises of plasma Copeptin (p-Copeptin) after CABG.Methods
A prespecified randomised double-blind substudy of GLUTAMICS II. Patients had left ventricular ejection fraction ≤0.30 or EuroSCORE II ≥3.0 and underwent CABG ± valve procedure. Intravenous infusion of 0.125 M L-glutamic acid or saline at 1.65 mL/kg/h was commenced 10–20 min before the release of the aortic cross-clamp and then continued for another 150 min P-Copeptin was measured preoperatively and postoperatively on day one (POD1) and day three. The primary endpoint was an increase in p-Copeptin from the preoperative level to POD1. Postoperative stroke ≤24 h and mortality ≤30 days were safety outcomes.Results
We included 181 patients of whom 48% had diabetes. The incidence of postoperative mortality ≤30 days (0% vs. 2.1%; p = .50) and stroke ≤24 h (0% vs. 3.2%; p = .25) did not differ between the glutamate group and controls. P-Copeptin increased postoperatively with the highest values recorded on POD1 without significant inter-group differences. Among patients without diabetes, p-Copeptin did not differ preoperatively but postoperative rise from preoperative level to POD1 was significantly reduced in the glutamate group (73 ± 66 vs. 115 ± 102 pmol/L; p = .02). P-Copeptin was significantly lower in the Glutamate group on POD1 (p = .02) and POD 3 (p = .02).Conclusions
Glutamate did not reduce rises of p-Copeptin significantly after moderate to high-risk CABG. However, glutamate was associated with reduced rises of p-Copeptin among patients without diabetes. These results agree with previous observations suggesting that glutamate mitigates myocardial dysfunction after CABG in patients without diabetes. Given the exploratory nature of these findings, they need to be confirmed in future studies. 相似文献2.
Alessandro Mandurino-Mirizzi Vilma Kajana Stefano Cornara Alberto Somaschini Andrea Demarchi Marco Galazzi Gabriele Crimi Marco Ferlini Rita Camporotondo Massimiliano Gnecchi Maurizio Ferrario Luigi Oltrona-Visconti Gaetano M. De Ferrari 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(7):2140-2143
BackgroundContrast associated-acute kidney injury (CA-AKI) has been associated with adverse outcomes after ST-segment elevation myocardial infarction (STEMI). However, early markers of CA-AKI are still needed to improve risk stratification. We investigated the association between elevated serum uric acid (eSUA) and CA-AKI in patients with STEMI treated with primary percutaneous coronary intervention (pPCI).Methods and resultsSerum creatinine (Scr) was measured at admission and 24, 48 and 72 h after pPCI. CA-AKI was defined as an increase of 25% (CA-AKI 25%) or 0.5 mg/dl (CA-AKI 0.5) of Scr level above the baseline after 48 h following contrast administration. Multivariable analyses to investigate CA-AKI predictors were performed by binary logistic regression and multivariable backward logistic regression model.In the 3023 patients considered, CA-AKI was more frequent among patients with eSUA as compared with patients with normal SUA levels, considering both CA-AKI definitions (CA-AKI25%: 20.8% vs 16.2%, p < 0.012; CA-AKI 0.5: 10.1% vs 5.8%, p < 0.001). The association between eSUA and CA-AKI was confirmed at multivariable analyses (CA-AKI 25%: odd ratio 1.32, 95% CI 1.03–1.69, p = 0.027; CA-AKI 0.5: odd ratio 1.76, 95% CI 1.11–2.79, p = 0.016).ConclusionElevated serum uric acid is associated with CA-AKI after reperfusion in patients with STEMI treated with pPCI. 相似文献
3.
Background:Work-related stress (WRS) in the healthcare sector is a major issue for both workers and organizations. To date, no consensus exists regarding differences in gender susceptibility to WRS in healthcare workers (HCWs).Objectives:The purpose of this study was to analyze how male and female HCWs employed in emergency departments experienced WRS.Methods:A cross-sectional study was conducted regarding the perception of WRS in registered nurses employed in emergency departments. The Italian version of the Job Content Questionnaire and the Rapid Stress Assessment scale were administrated to 710 registered nurses.Results:The WRS assessment showed that significantly more females than males were in a situation of isostrain (18.5% vs 9.8% p<0,05). In females, low social support was associated with high levels of job strain (18,5% vs 4,4% p<0,05).Conclusion:This study reflects the need for a gender-specific approach in the evaluation of WRS in the healthcare sector, and is consistent with literature that evidenced gender differences in the perception of WRS. Lack of social support proved to be a determinant of WRS in female HCWs. Organizational interventions aimed at providing a more suitable workgroup design are required in order to minimize WRS in female HCWs.Key words: Stress, risk assessment, nurses, emergency department, social support 相似文献
4.
A.V. Marzano G. Genovese G. Casazza M.T. Fierro P. Dapavo N. Crimi S. Ferrucci P. Pepe S. Liberati P.D. Pigatto A. Offidani E. Martina G. Girolomoni M. Rovaris C. Foti L. Stingeni A. Cristaudo G.W. Canonica E. Nettis R. Asero 《Journal of the European Academy of Dermatology and Venereology》2019,33(5):918-924
5.
Deissler Heidrun L. Lang Gerhard K. Lang Gabriele E. 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2019,257(1):83-94
Graefe's Archive for Clinical and Experimental Ophthalmology - Intravitreal injection of the VEGF-binding protein aflibercept is widely used to treat various ocular diseases. In vitro,... 相似文献
6.
Ester Orlandi MD Stefano Cavalieri MD Roberta Granata MD Piero Nicolai MD Paolo Castelnuovo MD Cesare Piazza MD Alberto Schreiber MD Mario Turri-Zanoni MD Pasquale Quattrone MD Rosalba Miceli MD Gabriele Infante PhD Fausto Sessa MD Carla Facco MD Giuseppina Calareso MD Nicola Alessandro Iacovelli MD Davide Mattavelli MD Alberto Paderno MD Carlo Resteghini MD Laura Deborah Locati MD Lisa Licitra MD Paolo Bossi MD 《The Laryngoscope》2020,130(4):857-865
7.
8.
9.
10.
Lukas Wisgrill Anja Weinhandl Lukas Unterasinger Gabriele Amann Rudolf Oehler Martin L. Metzelder Angelika Berger Thomas M. Benkoe 《Journal of pediatric surgery》2019,54(3):449-454