全文获取类型
收费全文 | 707篇 |
免费 | 40篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 18篇 |
妇产科学 | 30篇 |
基础医学 | 147篇 |
口腔科学 | 12篇 |
临床医学 | 46篇 |
内科学 | 85篇 |
皮肤病学 | 16篇 |
神经病学 | 94篇 |
特种医学 | 12篇 |
外科学 | 50篇 |
预防医学 | 102篇 |
眼科学 | 21篇 |
药学 | 78篇 |
中国医学 | 1篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 1篇 |
2022年 | 6篇 |
2021年 | 24篇 |
2020年 | 23篇 |
2019年 | 27篇 |
2018年 | 33篇 |
2017年 | 15篇 |
2016年 | 17篇 |
2015年 | 19篇 |
2014年 | 30篇 |
2013年 | 36篇 |
2012年 | 83篇 |
2011年 | 70篇 |
2010年 | 45篇 |
2009年 | 30篇 |
2008年 | 53篇 |
2007年 | 38篇 |
2006年 | 48篇 |
2005年 | 38篇 |
2004年 | 29篇 |
2003年 | 33篇 |
2002年 | 26篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1965年 | 2篇 |
1940年 | 3篇 |
排序方式: 共有754条查询结果,搜索用时 18 毫秒
1.
Jessica Roy Emma Williamson Katherine Pitt Nicky Stanley Mei-See Man Gene Feder Eszter Szilassy 《Health & social care in the community》2022,30(1):165-174
One in five children in the UK are affected by domestic violence and abuse. However, primary care clinicians (GPs and nurses) struggle to effectively identify and support children and young people living in homes where it is present. The IRIS+ (Enhanced Identification and Referral to Improve Safety) training and advocacy support intervention aimed to improve how clinicians respond to children and young people affected by domestic violence and abuse. IRIS+ training was delivered as part of a feasibility study to four general practices in an urban area in England (UK). Our mixed method design included interviews and questionnaires about the IRIS+ intervention with general practice patients, including children and young people as well as with clinicians and advocacy service providers. We collected the number of identifications and referrals by clinicians of children experiencing domestic violence and abuse through a retrospective search of medical and agency records 10 months after the intervention. Forty-nine children exposed to domestic violence and abuse were recorded in medical records. Thirty-five children were referred to a specialist domestic violence and abuse support service over a period of 10 months. Of these, 22 received direct or indirect support. The qualitative findings indicated that children benefitted from being referred by clinicians to the service. However, several barriers at the patient and professional level prevented children and young people from being identified and supported. Some of these barriers can be addressed through modifications to professional training and guidance, but others require systematic and structural changes to the way health and social care services work with children affected by domestic violence and abuse. 相似文献
2.
Balázs Nemes Réka P. Szabó Dávid Péntek Ildikó Nagy Gergely Ivády Bettina Kárai Eszter Szánthó Zsuzsa Hevessy Sándor Sipka Gergő J. Szőllősi Sándor Baráth 《Transplantation proceedings》2021,53(5):1423-1432
IntroductionThe usage of extended-criteria donors (ECD) became a routinely accepted manner in the last decade. ECD is a potential risk factor for antibody-mediated rejection. Analysis of lymphocyte subsets might be a complementary diagnostic toolkit because there is limited knowledge about this term.MethodBetween May 12, 2016, and September 4, 2019, a total of 130 patients who had undergone kidney transplant were investigated. Patients were divided in ECD and standard criteria donor (SCD) groups. Blood samples were collected before the operation, then in the first week and after 30, 60, 180, and 365 days. Besides routine laboratory tests, multicolor flow cytometry was performed for lymphocyte subsets.ResultsECD grafts were transplanted to older recipients. The number of CD4+ cells increased in the SCDs from the first week to until the end of first month, and then decreased. The number of CD4+ cells decreased from the beginning of the study until the end of first year to 66% of its original value in ECDs. At the first month, the number of CD19+ cells was higher in SCD compared with ECD cases; the number then decreased in both groups. T-regulatory cells had a drop at the first week that lasted until the first month. A bigger increase in SCD and a moderate increase in ECD group were then observed. The kinetics of CD19+ and CD19+ naive cells are similar in the ECD and SCD groups. In the SCD group, cell count decreased in both CD19+ (13%) and CD19+ naive (12%) between third and sixth month. The count of CD19+ cells decreased by 9%, but the count of CD19+ naive cells increased by 11% between the sixth month and first year.DiscussionThe prolonged postoperative uremic state caused by the poorer initial function, together with an aging immune system, explains the weaker immune response in ECD patients, which may be the cause of the decreased number of memory and regulatory T cells. Older patients with an ECD graft need a tailored, personalized, and less aggressive immunosuppressive treatment. 相似文献
3.
Dra Szarka Grta Elekes Orsolya Berczeli Eszter Vizvri Lszl Szalay Chuanqing Ding Lszl Tlosi Edit Tth-Molnr 《Investigative ophthalmology & visual science》2020,61(14)
PurposeThe role of adrenergic innervation in the regulation of lacrimal gland (LG) ductal fluid secretion is unknown. The Aim of the present study was to investigate the effect of adrenergic stimulation on fluid secretion in isolated LG duct segments and to study the underlying intracellular mechanisms.MethodsFluid secretion of isolated mouse LG ducts was measured using video-microscopy. Effect of various adrenergic agonists (norepinephrine, phenylephrine, and isoproterenol) on fluid secretion as well as inhibitory effects of specific antagonists on adrenergic agonist-stimulated secretory response were analyzed. Changes in intracellular Ca2+ level [Ca2+i] were investigated with microfluorometry.ResultsBoth norepinephrine and phenylephrine initiated a rapid and robust fluid secretory response, whereas isoproterenol did not cause any secretion. Phenylephrine-induced secretion was completely blocked by α1D-adrenergic receptor blocker BMY-7378. The endothelial nitric oxide synthase (eNOS) inhibitor L-NAME or guanylyl cyclase inhibitor ODQ reduced but not completely abolished the phenylephrine-induced fluid secretion, whereas co-administration of Ca2+-chelator BAPTA-AM resulted in a complete blockade. Phenylephrine stimulation induced a small, but statistically significant elevation in [].ConclusionsOur results prove the direct role of α1-adrenergic stimulation on LG ductal fluid secretion. Lack of isoproterenol-induced fluid secretory response suggests the absence of β-receptor mediated pathway in mouse LG ducts. Complete blockade of phenylephrine-induced fluid secretion by BMY-7378 and predominant inhibition of the secretory response either by L-NAME or ODQ suggest that α-adrenergic agonists use the NO/cGMP pathway through α1D receptor. Ca2+ signaling independent from NO/cGMP pathway may also play an at least partial role in α-adrenergic induced ductal fluid secretion. 相似文献
4.
5.
Duds Eszter Susa va Pamjav Horolma Szabolcsi Zoltn 《International journal of legal medicine》2020,134(2):487-489
International Journal of Legal Medicine - Gyula Ágner was a Royal Hungarian First Lieutenant (1st Lt.) during the World War II and died at 30 years old due to a mine shrapnel injury... 相似文献
6.
7.
8.
9.
10.
Nagy Eszter Jócsák Ildikó Csivincsik Ágnes Zsolnai Attila Halász Tibor Nyúl András Plucsinszki Zsolt Simon Tamás Szabó Szilárd Turbók Janka Nemes Csaba Sugár László Nagy Gábor 《Parasitology research》2018,117(11):3683-3687
Parasitology Research - During the monitoring of red deer (N = 124) and fallow deer (N = 13) populations in four neighbouring areas, the presence of Fascioloides magna... 相似文献