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Platelets have diverse roles in immune processes in addition to their key functions in haemostasis and thrombosis. Some studies imply that platelets may be possibly related to the immune tolerance induction. However, the role of platelets in the development of immune tolerance is not fully understood. The purpose of this study was to investigate the role of platelets in the development of regulatory mechanisms responsible for cutaneous inflammation using a mouse model of low zone tolerance (LZT). Mice were treated with 2,4,6‐trinitro‐1‐chlorobenzene (TNCB) 8 times every other day for tolerance induction with administration of anti‐platelet antibody or control antibody during the tolerance induction phase every 3 days. After the treatment for the tolerance induction, mice were sensitized and then challenged with TNCB. The contact hypersensitivity (CHS) was significantly decreased at 24 hours after challenge in the mice with LZT than in those without LZT. Platelet depletion via administration of anti‐platelet antibody reversed the inhibition of CHS and reduced the frequency of Foxp3+ Tregs in the inflamed skin and draining lymph nodes in mice with LZT. In addition, repeated low‐dose skin exposure resulted in elevated plasma levels of transforming growth factor (TGF)‐β1. Interestingly, platelet depletion reduced plasma TGF‐β1 levels of mice with LZT. Furthermore, the CHS response was reduced by administration of recombinant TGF‐β1 during platelet depletion in mice with LZT. Administration of anti‐TGF‐β antibody reversed the inhibition of the CHS responses. These results suggest that platelets are involved in the induction of immune tolerance via the release of TGF‐β1. 相似文献
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Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield 下载免费PDF全文
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Chika Ohata Bungo Ohyama Eri Katayama Takekuni Nakama 《The Journal of dermatology》2020,47(4):405-408
We evaluated the efficacy and safety of interleukin (IL)-17 inhibitors (IL-17i) by analyzing 66 patients with psoriasis treated with secukinumab (n = 25), ixekizumab (n = 17) and brodalumab (n = 24) at Kurume University Hospital between December 2014 and June 2019. The mean Psoriasis Area and Severity Index (PASI) scores at baseline were 12.9, 13.4 and 9.9 in the secukinumab, ixekizumab and brodalumab groups (SECg, IXEg and BROg), respectively. At the 6-month evaluation, the mean PASI scores were 1.7, 1.1 and 0.5 in SECg, IXEg and BROg, respectively. The proportion of patients achieving PASI of 3.0 or less was significantly lower in SECg. Drug survivals showed no significant difference among the groups. Although one patient in IXEg died due to an unknown cause, no serious IL-17i-associated adverse event was observed. This study showed high efficacy and relatively low risk of the treatment with IL-17i. 相似文献
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Nouchine Hadjikhani MD PhD Daniel S. Albrecht PhD Caterina Mainero MD PhD Eri Ichijo MS Noreen Ward MS Cristina Granziera MD PhD Nicole R. Zürcher PhD Oluwaseun Akeju MD Guillaume Bonnier PhD Julie Price PhD Jacob M. Hooker PhD Vitaly Napadow PhD Matthias Nahrendorf MD PhD Marco L. Loggia PhD Michael A. Moskowitz MD 《Annals of neurology》2020,87(6):939-949
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Mase Kaori Saito Chie Usui Joichi Arimura Yoshihiro Nitta Kosaku Wada Takashi Makino Hirofumi Muso Eri Hirawa Nobuhito Kobayashi Masaki Yumura Wako Fujimoto Shouichi Nakagawa Naoki Ito Takafumi Yuzawa Yukio Matsuo Seiichi Yamagata Kunihiro 《Clinical and experimental nephrology》2022,26(11):1092-1099
Clinical and Experimental Nephrology - The life prognosis of elderly patients with myeloperoxidase–anti-neutrophil cytoplasmic antibodies-associated vasculitis (MPO-AAV) has been improved by... 相似文献