全文获取类型
收费全文 | 1014篇 |
免费 | 67篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 13篇 |
妇产科学 | 20篇 |
基础医学 | 171篇 |
口腔科学 | 58篇 |
临床医学 | 71篇 |
内科学 | 233篇 |
皮肤病学 | 12篇 |
神经病学 | 164篇 |
特种医学 | 21篇 |
外科学 | 103篇 |
综合类 | 2篇 |
预防医学 | 58篇 |
眼科学 | 10篇 |
药学 | 114篇 |
中国医学 | 6篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 16篇 |
2022年 | 22篇 |
2021年 | 72篇 |
2020年 | 36篇 |
2019年 | 55篇 |
2018年 | 59篇 |
2017年 | 43篇 |
2016年 | 41篇 |
2015年 | 37篇 |
2014年 | 53篇 |
2013年 | 84篇 |
2012年 | 96篇 |
2011年 | 92篇 |
2010年 | 54篇 |
2009年 | 31篇 |
2008年 | 50篇 |
2007年 | 34篇 |
2006年 | 39篇 |
2005年 | 38篇 |
2004年 | 39篇 |
2003年 | 40篇 |
2002年 | 23篇 |
2001年 | 10篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1984年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
排序方式: 共有1095条查询结果,搜索用时 62 毫秒
1.
Marc Evans MD Susanne Engberg MD Mads Faurby MSc João Diogo Da Rocha Fernandes MSc Pollyanna Hudson MSc William Polonsky PhD 《Diabetes, obesity & metabolism》2022,24(3):377-390
We designed a systematic literature review to identify available evidence on adherence to and persistence with antidiabetic medication in people with type 2 diabetes (T2D). Electronic screening and congress searches identified real-world noninterventional studies (published between 2010 and October 2020) reporting estimates of adherence to and persistence with antidiabetic medication in adults with T2D, and associations with glycaemic control, microvascular and/or macrovascular complications, hospitalizations and healthcare costs. Ninety-two relevant studies were identified, the majority of which were retrospective and reported US data. The proportions of patients considered adherent (median [range] 51.2% [9.4%-84.3%]) or persistent (median [range] 47.7% [16.9%-94.0%]) varied widely across studies. Multiple studies reported an association between greater adherence/persistence and greater reductions in glycated haemoglobin levels. Better adherence/persistence was associated with fewer microvascular and/or macrovascular outcomes, although there was little consistency across studies in terms of which outcomes were improved. More adherent and more persistent patients were typically less likely to be hospitalized or to have emergency department visits/admissions and spent fewer days in hospital annually than less adherent/persistent patients. Greater adherence and persistence were generally associated with lower hospitalization costs, higher pharmacy costs and lower or budget-neutral total healthcare costs compared with lower adherence/persistence. In conclusion, better adherence and persistence in people with T2D is associated with lower rates of microvascular and/or macrovascular outcomes and inpatient hospitalization, and lower or budget-neutral total healthcare expenditure. Education and treatment strategies to address suboptimal adherence and persistence are needed to improve clinical and economic outcomes. 相似文献
2.
3.
4.
Spontaneous reports of hypersensitivity adverse drug reactions in Portugal: a retrospective analysis
Diogo Mendes Ana Rita Oliveira Carlos Alves Francisco Batel Marques 《Expert opinion on drug safety》2020,19(6):763-769
ABSTRACT
Background
Hypersensitivity adverse drug reactions (ADRs) are usually serious, unpredictable, and associated with high morbidity and mortality. This study describes cases of hypersensitivity ADRs spontaneously reported in Central Portugal. 相似文献5.
Diogo Ribeiro Ana Rita Nunes Michael Gliksberg Savani Anbalagan Gil Levkowitz Rui F. Oliveira 《Journal of neuroendocrinology》2020,32(4)
Sociality is a complex phenomenon that involves the individual´s motivation to approach their conspecifics, along with social cognitive functions that enable individuals to interact and survive. The nonapeptide oxytocin (OXT) is known to regulate sociality in many species. However, the role of OXT in specific aspects of sociality is still not well understood. In the present study, we investigated the contribution of the OXT receptor (OXTR) signalling in two different aspects of zebrafish social behaviour: social preference, by measuring their motivation to approach a shoal of conspecifics, and social recognition, by measuring their ability to discriminate between a novel and familiar fish, using a mutant zebrafish lacking a functional OXTR. Although oxtr mutant zebrafish displayed normal attraction to a shoal of conspecifics, they exhibited reduced social recognition. We further investigated whether this effect would be social‐domain specific by replacing conspecific fish by objects. Although no differences were observed in object approach, oxtr mutant fish also exhibited impaired object recognition. Our findings suggest that OXTR signalling regulates a more general memory recognition of familiar vs novel entities, not only in social but also in a non‐social domain, in zebrafish. 相似文献
6.
Rafael L. Rosa Luclia Santi Markus Berger Emanuela F. Tureta Andr Quincozes-Santos Diogo O. Souza Jorge A. Guimares Walter O. Beys-da-Silva 《Journal of neurovirology》2020,26(1):77-83
The recent outbreak of Zika virus (ZIKV) in Brazil and other countries globally demonstrated the relevance of ZIKV studies. During and after this outbreak, there was an intense increase in scientific production on ZIKV infections, especially toward alterations promoted by the infection and related to clinical outcomes. Considering this massive amount of new data, mainly thousands of genes and proteins whose expression is impacted by ZIKV infection, the ZIKA Virus Infection Database (ZIKAVID) was created. ZIKAVID is an online database that comprises all genes or proteins, and associated information, for which expression was experimentally measured and found to be altered after ZIKV infection. The database, available at https://zikavid.org, contains 16,984 entries of gene expression measurements from a total of 7348 genes. It allows users to easily perform searches for different experimental hosts (cell lines, tissues, and animal models), ZIKV strains (African, Asian, and Brazilian), and target molecules (messenger RNA [mRNA] and protein), among others, used in differential expression studies regarding ZIKV infection. In this way, the ZIKAVID will serve as an additional and important resource to improve the characterization of the molecular impact and pathogenesis associated with ZIKV infection. 相似文献
7.
8.
9.
Diogo Teixeira urea Canelhas Miguel Costa Csar Magalhes Eduarda Osrio Ferreira Artur Csar 《Journal of cutaneous pathology》2022,49(1):86-89
Benign lymphangioendothelioma (BL, acquired progressive lymphangioma) is a rare, slow-growing lymphatic tumor, first described 40 years ago, with fewer than 50 published cases. Clinically, it presents as a skin-colored or erythematous patch. Definitive diagnosis requires histopathological examination. The immunohistochemical staining profile is still controversial regarding Wilms tumor 1 (WT1) expression, a marker of proliferative and neoplastic, rather than malformative nature. Here, we report a case of a 60-cm-long BL on the breast of an adult female. Biopsy revealed irregular vascular spaces dissecting the collagen bundles lined by swollen endothelial cells but without cellular atypia. Positivity for podoplanin (D2-40), CD31, and WT1 was observed, supporting the neoplastic nature of this lesion. Dermatologists and pathologists must be aware of this entity for early diagnosis and treatment. 相似文献
10.
Francesca Atkinson Richard Evans James E. Guest Emma P. Bavin Diogo Cacador Christopher Holland Deborah J. Guest 《Journal of tissue engineering and regenerative medicine》2020,14(5):690-700
Tendon injuries are a common cause of morbidity in humans. They also occur frequently in horses, and the horse provides a relevant, large animal model in which to test novel therapies. To develop novel cell therapies that can aid tendon regeneration and reduce subsequent reinjury rates, the mechanisms that control tendon tissue regeneration and matrix remodelling need to be better understood. Although a range of chemical cues have been explored (growth factors, media etc.), the influence of the mechanical environment on tendon cell culture has yet to be fully elucidated. To mimic the in vivo environment, in this study, we have utilised a novel and affordable, custom‐made bioreactor to apply a cyclical strain to tendon‐like constructs generated in three‐dimensional (3D) culture by equine tenocytes. Dynamic shear analysis (DSA), dynamic scanning calorimetry (DSC) and Fourier‐transform infrared (FTIR) spectroscopy were used to determine the mechanical and chemical properties of the resulting tendon‐like constructs. Our results demonstrate that equine tenocytes exposed to a 10% cyclical strain have an increased amount of collagen gel contraction after 7 and 8 days of culture compared with cells cultured in 3D in the absence of external strain. While all the tendon‐like constructs have a very similar chemical composition to native tendon, the application of strain improves their mechanical properties. We envisage that these results will contribute towards the development of improved biomimetic artificial tendon models for the development of novel strategies for equine regenerative therapies. 相似文献