全文获取类型
收费全文 | 393篇 |
免费 | 19篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 11篇 |
妇产科学 | 2篇 |
基础医学 | 25篇 |
口腔科学 | 5篇 |
临床医学 | 22篇 |
内科学 | 52篇 |
皮肤病学 | 105篇 |
神经病学 | 13篇 |
特种医学 | 7篇 |
外科学 | 46篇 |
综合类 | 8篇 |
预防医学 | 15篇 |
眼科学 | 14篇 |
药学 | 38篇 |
中国医学 | 7篇 |
肿瘤学 | 37篇 |
出版年
2023年 | 6篇 |
2022年 | 3篇 |
2021年 | 9篇 |
2020年 | 14篇 |
2019年 | 10篇 |
2018年 | 13篇 |
2017年 | 8篇 |
2016年 | 12篇 |
2015年 | 14篇 |
2014年 | 16篇 |
2013年 | 26篇 |
2012年 | 31篇 |
2011年 | 40篇 |
2010年 | 15篇 |
2009年 | 12篇 |
2008年 | 24篇 |
2007年 | 34篇 |
2006年 | 21篇 |
2005年 | 23篇 |
2004年 | 13篇 |
2003年 | 6篇 |
2002年 | 8篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有414条查询结果,搜索用时 171 毫秒
1.
2.
Kristen E. Pauken Osmaan Shahid Kaitlyn A. Lagattuta Kelly M. Mahuron Jacob M. Luber Margaret M. Lowe Linglin Huang Conor Delaney Jaclyn M. Long Megan E. Fung Kathleen Newcomer Katy K. Tsai Melissa Chow Samantha Guinn Juhi R. Kuchroo Kelly P. Burke Jason M. Schenkel Michael D. Rosenblum Adil I. Daud Arlene H. Sharpe Meromit Singer 《The Journal of experimental medicine》2021,218(4)
3.
4.
Abdul Latif L Daud Amadera JE Pimentel D Pimentel T Fregni F 《Archives of physical medicine and rehabilitation》2011,(2):306-315
Abdul Latif L, Daud Amadera JE, Pimentel D, Pimentel T, Fregni F. Sample size calculation in physical medicine and rehabilitation: a systematic review of reporting, characteristics, and results in randomized controlled trials.
Objective
To assess systematically the reporting of sample size calculation in randomized controlled trials (RCTs) in 5 leading journals in the field of physical medicine and rehabilitation (PM&R).Data Sources
The data source was full reports of RCTs in 5 leading PM&R journals (Journal of Rehabilitation Medicine, Archives of Physical Medicine and Rehabilitation, American Journal of Physical Medicine and Rehabilitation, Clinical Rehabilitation, and Disability and Rehabilitation) between January and December of 1998 and 2008. Articles were identified in Medline.Study Selection
A total of 111 articles met our inclusion criteria, which include RCTs of human studies in the 5 selected journals.Data Extraction
Sample size calculation reporting and trial characteristics were collected for each trial by independent investigators.Data Synthesis
In 2008, 57.3% of articles reported sample size calculation as compared with only 3.4% in 1998. The parameters that were commonly used were a power of 80% and alpha of 5%. Articles often failed to report effect size or effect estimates for sample size calculation. Studies reporting sample size calculation were more likely to describe the main outcome and to have a sample size greater than 50 subjects. The study outcome (positive vs negative) was not associated with the likelihood of sample size reporting. Trial characteristics of the 2 periods (1998 vs 2008) were similar except that in 1998 there were more negative studies compared with 2008.Conclusions
Although sample size calculation reporting has improved dramatically in 10 years and is comparable with other fields in medicine, it is still not adequate given current publication guidelines. 相似文献5.
6.
Introduction: Combination therapy with BRAF and MEK inhibitors is a recommended treatment strategy for metastatic melanoma patients with BRAFV600 mutations. This treatment provides significant response rates and little added toxicity, with relatively improved survival outcomes compared to RAF/MEK inhibitor monotherapy and chemotherapy.Areas covered: This review covers the pharmacology, efficacy, and toxicity data derived from clinical studies of dabrafenib, trametinib, and the combination thereof. The major downfall of combiDT is the limited durability of response, which is largely due to acquired resistance in the MAPK pathway.Expert opinion: Future directions of combiDT concentrate on further combinations with immunotherapy or other targeted inhibitors, referred to triple-agent therapy, which may be essential to improving durability of responses and overcoming resistance. 相似文献
7.
Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate‐to‐severe plaque psoriasis: data from the Spanish Biologics Registry,Biobadaderm 下载免费PDF全文
I. Belinchón J.M. Ramos G. Carretero C. Ferrándiz R. Rivera E. Daudén P. De la Cueva‐Dobao F.J. Gómez‐García E. Herrera‐Ceballos J.L. Sánchez‐Carazo J.L. López‐Estebaranz M. Alsina M. Ferrán R. Torrado J.M. Carrascosa M. Llamas‐Velasco P.L. Ortiz I. García‐Doval M.A. Descalzo The Biobadaderm Study Group 《Journal of the European Academy of Dermatology and Venereology》2017,31(10):1700-1708
8.
9.
10.
Qandeel Rehman Aimal Daud Khan Adnan Daud Khan Muhammad Noman Haider Ali Abdul Rauf Muhammad Shakeel Ahmad 《RSC advances》2019,9(59):34207
Improving the photon absorption in thin-film solar cells with plasmonic nanoparticles is essential for the realization of extremely efficient cells with substantial cost reduction. Here, a comprehensive study of solar energy enhancement in a cadmium telluride (CdTe) thin-film solar cell based on the simple design of a square array of plasmonic titanium nanoparticles, has been reported. The excitation of localized plasmons in the metallic nanostructures together with the antireflection coating (ARC) significantly enhances the absorption of photons in the active CdTe layer. The proposed structure attained super absorption with a mean absorbance of more than 97.27% covering a wide range from visible to near-infrared (i.e., from 300 nm to 1200 nm), presenting a 90% absorption bandwidth over 900 nm, and the peak absorption is up to 99.9%. For qualitative analysis, the photocurrent density is also estimated for AM 1.5 solar illumination (global tilt), whose value reaches 40.36 mA cm−2, indicating the highest value reported to date. The impact of nanoparticle dimensions, various metal materials, shapes, and random arrangement of nanoparticles on optical absorption are discussed in detail. Moreover, the angle insensitivity is essentially validated by examining the absorption performance with oblique incidences and it is found that the solar cell keeps high absorption efficiency even when the incidence angle is greater than 0°. Therefore, these findings suggest that the proposed broadband structure has good prospect in attaining high power conversion efficiency while reducing the device cost.Improving the photon absorption in thin-film solar cells with plasmonic nanoparticles is essential for the realization of extremely efficient cells with substantial cost reduction. 相似文献