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排序方式: 共有1943条查询结果,搜索用时 31 毫秒
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Hielke M. de Vries Hack Jae Lee Wayne Lam Rosa S. Djajadiningrat Sarah R. Ottenhof Eduard Roussel Bin Klaas Kroon Igle Jan de Jong Pedro Oliveira Hussain M. Alnajjar Maarten Albersen Asif Muneer Vijay Sangar Arie Parnham Benjamin Ayres Nick Watkin Simon Horenblas Martijn M. Stuiver Oscar R. Brouwer 《BJU international》2022,130(1):126-132
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S.G. Brouwer de Koning T.P. ter Braak F. Geldof R.L.P. van Veen M.J.A. van Alphen L.H.E. Karssemakers W.H. Schreuder M.B. Karakullukcu 《International journal of oral and maxillofacial surgery》2021,50(3):287-293
In mandibular surgery, three-dimensionally printed patient-specific cutting guides are used to translate the preoperative virtually planned resection planes to the operating room. This study was performed to determine whether cutting guides are positioned according to the virtual plan and to compare the intraoperative position of the cutting guide with the resection performed. Nine patients were included. The exact positions of the resection planes were planned virtually and a patient-specific cutting guide was designed and printed. After surgical placement of the cutting guide, intraoperative cone beam computed tomography (CBCT) was performed. Postoperative CT was used to obtain the final resection planes. Distances and yaw and pitch angles between the preoperative, intraoperative, and postoperative resection planes were calculated. Cutting guides were positioned on the mandible with millimetre accuracy. Anterior osteotomies were performed more accurately than posterior osteotomies (intraoperatively positioned and final resection planes differed by 1.2 ± 1.0 mm, 4.9 ± 6.6°, and 1.8 ± 1.5°, respectively, and by 2.2 ± 0.9 mm, 9.3 ± 9°, and 8.3 ± 6.5° respectively). Differences between intraoperatively planned and final resection planes imply a directional freedom of the saw through the saw slots. Since cutting guides are positioned with millimetre accuracy compared to the virtual plan, the design of the saw slots in the cutting guides needs improvement to allow more accurate resections. 相似文献
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de Lange GL Tadjoedin E Bouw EA Brouwer MC 《Nederlands tijdschrift voor tandheelkunde》1997,104(7):271-273
The problem of insufficient alveolar bone in the edentulous maxilla caused by resorption and pneumatization can be overcome by augmentation of the sinus floor to increase bone volume for the placement of dental implants. The quality of bone which is achieved after sinus floor augmentation is hardly known. This study describes the histologic results obtained three till six months after sinus floor augmentation with autogenous bone from the iliac crest in patients with severe maxillary bone resorption. The bone biopsies taken from the implant sites showed a substantial bone volume with a mature trabecular pattern and active bone growth. It was concluded that with the obtained bone quality, the sinus floor augmentation procedure can be a good treatment modality for the rehabilitation with implants in patients with severe maxillary bone atrophy. 相似文献
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Martje E. van Egmond MD Corien C. Verschuuren‐Bemelmans MD Esther A. Nibbeling MSc Jan Willem J. Elting MD PhD Deborah A. Sival MD PhD Oebele F. Brouwer MD PhD Jeroen J. de Vries MD Hubertus P. Kremer MD PhD Richard J. Sinke PhD Marina A. Tijssen MD PhD Tom J. de Koning MD PhD 《Movement disorders》2014,29(1):139-143
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Danielle Remmerswaal Jorg Huijding Samantha Bouwmeester Marlies Brouwer Peter Muris 《Journal of behavior therapy and experimental psychiatry》2014
Background and objectives
Some cognitive models propose that information processing biases and fear are reciprocally related. This idea has never been formally tested. Therefore, this study investigated the existence of a vicious circle by which confirmation bias and fear exacerbate each other.Methods
One-hundred-and-seventy-one school children (8–13 years) were first provided with threatening, ambiguous, or positive information about an unknown animal. Then they completed a computerized information search task during which they could collect additional (negative, positive, or neutral) information about the novel animal. Because fear levels were repeatedly assessed during the task, it was possible to examine the reciprocal relationship between confirmation bias and fear.Results
A reciprocal relation of mutual reinforcement was found between confirmation bias and fear over the course of the experiment: increases in fear predicted subsequent increases in the search for negative information, and increases in the search for negative information further enhanced fear on a later point-in-time. In addition, the initial information given about the animals successfully induced diverging fear levels in the children, and determined their first inclination to search for additional information.Limitations
As this study employed a community sample of primary school children, future research should test whether these results can be generalized to clinically anxious youth.Conclusions
These findings provide first support for the notion that fearful individuals may become trapped in a vicious circle in which fear and a fear-related confirmation bias mutually strengthen each other, thereby maintaining the anxiety pathology. 相似文献10.
In acute experimental autoimmune encephalomyelitis,infiltrating macrophages are immune activated,whereas microglia remain immune suppressed 下载免费PDF全文
I. D. Vainchtein J. Vinet N. Brouwer S. Brendecke G. Biagini K. Biber H. W. G. M. Boddeke B. J. L. Eggen 《Glia》2014,62(10):1724-1735
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) characterized by loss of myelin accompanied by infiltration of T‐lymphocytes and monocytes. Although it has been shown that these infiltrates are important for the progression of MS, the role of microglia, the resident macrophages of the CNS, remains ambiguous. Therefore, we have compared the phenotypes of microglia and macrophages in a mouse model for MS, experimental autoimmune encephalomyelitis (EAE). In order to properly discriminate between these two cell types, microglia were defined as CD11bpos CD45int Ly‐6Cneg, and infiltrated macrophages as CD11bpos CD45high Ly‐6Cpos. During clinical EAE, microglia displayed a weakly immune‐activated phenotype, based on the expression of MHCII, co‐stimulatory molecules (CD80, CD86, and CD40) and proinflammatory genes [interleukin‐1β (IL‐1β) and tumour necrosis factor‐ α (TNF‐α)]. In contrast, CD11bpos CD45high Ly‐6Cpos infiltrated macrophages were strongly activated and could be divided into two populations Ly‐6Cint and Ly‐6Chigh, respectively. Ly‐6Chigh macrophages contained less myelin than Ly‐6Cint macrophages and expression levels of the proinflammatory cytokines IL‐1β and TNF‐α were higher in Ly‐6Cint macrophages. Together, our data show that during clinical EAE, microglia are only weakly activated whereas infiltrated macrophages are highly immune reactive. GLIA 2014;62:1724–1735 相似文献