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排序方式: 共有1459条查询结果,搜索用时 125 毫秒
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Markus G. Seidel Katrin Böhm Figen Dogu Austen Worth Adrian Thrasher Benoit Florkin Aydan İkincioğulları Anke Peters Shahrzad Bakhtiar Marie Meeths Polina Stepensky Isabelle Meyts Svetlana O. Sharapova Laura Gámez-Díaz Lennart Hammarström Stephan Ehl Bodo Grimbacher Andrew R. Gennery 《The Journal of allergy and clinical immunology》2018,141(2):770-775.e1
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Susanne Unger Maximilian Seidl Pauline van Schouwenburg Mirzokhid Rakhmanov Alla Bulashevska Natalie Frede Bodo Grimbacher Jens Pfeiffer Klaudia Schrenk Luis Munoz Leif Hanitsch Ina Stumpf Fabian Kaiser Oliver Hausmann Florian Kollert Sigune Goldacker Mirjam van der Burg Baerbel Keller Klaus Warnatz 《The Journal of allergy and clinical immunology》2018,141(2):730-740
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Desirée Schubert Marie-Christine Klein Sarah Hassdenteufel Andrés Caballero-Oteyza Linlin Yang Michele Proietti Alla Bulashevska Janine Kemming Johannes Kühn Sandra Winzer Stephan Rusch Manfred Fliegauf Alejandro A. Schäffer Stefan Pfeffer Roger Geiger Adolfo Cavalié Hongzhi Cao Fang Yang Bodo Grimbacher 《The Journal of allergy and clinical immunology》2018,141(4):1427-1438
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Roggenbuck D Reinhold D Wex T Goihl A von Arnim U Malfertheiner P Büttner T Porstmann T Porstmann S Liedvogel B Bogdanos DP Laass MW Conrad K 《Clinica chimica acta; international journal of clinical chemistry》2011,412(9-10):718-724
BackgroundCrohn's disease (CD) is an inflammatory bowel disease (IBD) characterized by reactivity against microbial and self antigens. Zymogen granule glycoprotein 2 (GP2) was identified as the major autoantigen of CD-specific pancreatic autoantibodies (PAB).MethodsHuman GP2 was expressed in the Spodoptera frugiperda 9 (Sf9) cell line using the baculovirus system, purified by Ni-chelate chromatography, and used as antigen for anti-GP2 IgA and IgG assessment by enzyme-linked immunosorbent assays (ELISA). Antibodies to mannan of Saccharomyces cerevisiae (ASCA), PAB, and anti-GP2 were investigated in sera of 178 CD patients, 100 ulcerative colitis (UC) patients, and 162 blood donors (BD).ResultsAnti-GP2 IgG and IgA were found in 48/72 (66.7%) and 23/72 (31.9%) PAB positive and 5/106 (4.7%) and 1/106 (0.9%) PAB negative CD patients (p < 0.0001), respectively. CD patients displayed significantly higher reactivity to GP2 than UC patients and BD (p < 0.0001), respectively. Occurrence of anti-GP2 antibodies correlated with PAB reactivity (Spearmen's rho = 0.493, p < 0.00001). There was a significant relationship between the occurrence of ASCA IgG and anti-GP2 IgG (p = 0.0307).ConclusionsAnti-GP2 IgG and IgA constitute novel CD specific autoantibodies, the quantification of which could improve the serological diagnosis of IBD. 相似文献
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Sahra Bodo Magali Svrcek Isabelle Sourrouille Peggy Cuillières-Dartigues Tatiana Ledent Sylvie Dumont Laetitia Dinard Philippe Lafitte Camille Capel Ada Collura Olivier Buhard Kristell Wanherdrick Alexandra Chalastanis Virginie Penard-Lacronique Bettina Fabiani Jean-Fran?ois Fléjou Nicole Brousse Laurent Beaugerie Alex Duval Martine Muleris 《Oncotarget》2015,6(28):24969-24977
Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system. We performed a dose effect study in mice to investigate the development of MSI lymphomas associated with long term Aza treatment. Over two years, Aza was administered to mice that were wild type, null or heterozygous for the MMR gene Msh2. Ciclosporin A, an immunosuppressant with an MMR-independent signaling, was also administered to Msh2wt mice as controls. Survival, lymphoma incidence and MSI tumor phenotype were investigated. Msh2+/− mice were found more tolerant than Msh2wt mice to the cytotoxicity of Aza. In Msh2+/− mice, Aza induced a high incidence of MSI lymphomas in a dose-dependent manner. In Msh2wt mice, a substantial lifespan was only observed at the lowest Aza dose. It was associated with the development of lymphomas, one of which displayed the MSI phenotype, unlike the CsA-induced lymphomas. Our findings define Aza as a risk factor for an MSI-driven lymphomagenesis process. 相似文献
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Physician's appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort 下载免费PDF全文
Linus B. Grabenhenrich Andreas Reich Doreen McBride Aline Sprikkelman Graham Roberts Kate E. C. Grimshaw Alessandro G. Fiocchi Photini Saxoni‐Papageorgiou Nikolaos G. Papadopoulos Ana Fiandor Santiago Quirce Marek L. Kowalski Sigurveig T. Sigurdardottir Ruta Dubakiene Jonathan O. B. Hourihane Leonard Rosenfeld Bodo Niggemann Thomas Keil Kirsten Beyer 《Pediatric allergy and immunology》2018,29(1):58-65
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