全文获取类型
收费全文 | 3977篇 |
免费 | 224篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 192篇 |
妇产科学 | 88篇 |
基础医学 | 532篇 |
口腔科学 | 31篇 |
临床医学 | 260篇 |
内科学 | 798篇 |
皮肤病学 | 64篇 |
神经病学 | 253篇 |
特种医学 | 103篇 |
外科学 | 430篇 |
综合类 | 235篇 |
一般理论 | 5篇 |
预防医学 | 344篇 |
眼科学 | 82篇 |
药学 | 335篇 |
中国医学 | 64篇 |
肿瘤学 | 357篇 |
出版年
2023年 | 24篇 |
2022年 | 19篇 |
2021年 | 104篇 |
2020年 | 57篇 |
2019年 | 73篇 |
2018年 | 84篇 |
2017年 | 77篇 |
2016年 | 95篇 |
2015年 | 99篇 |
2014年 | 131篇 |
2013年 | 179篇 |
2012年 | 273篇 |
2011年 | 258篇 |
2010年 | 158篇 |
2009年 | 128篇 |
2008年 | 193篇 |
2007年 | 211篇 |
2006年 | 185篇 |
2005年 | 185篇 |
2004年 | 168篇 |
2003年 | 164篇 |
2002年 | 121篇 |
2001年 | 102篇 |
2000年 | 94篇 |
1999年 | 74篇 |
1998年 | 28篇 |
1997年 | 22篇 |
1996年 | 20篇 |
1995年 | 20篇 |
1994年 | 22篇 |
1993年 | 22篇 |
1992年 | 64篇 |
1991年 | 57篇 |
1990年 | 48篇 |
1989年 | 45篇 |
1988年 | 45篇 |
1987年 | 31篇 |
1986年 | 44篇 |
1985年 | 41篇 |
1984年 | 22篇 |
1983年 | 28篇 |
1979年 | 29篇 |
1977年 | 20篇 |
1975年 | 22篇 |
1974年 | 20篇 |
1973年 | 31篇 |
1972年 | 36篇 |
1971年 | 23篇 |
1970年 | 27篇 |
1968年 | 26篇 |
排序方式: 共有4211条查询结果,搜索用时 15 毫秒
1.
Shantata Kudchadkar Safia Ahmed Tanmoy Mukherjee Jayesh Sagar 《World journal of gastrointestinal oncology》2022,14(4):833-841
Incidence of colorectal cancer (CRC) is on rise. While approximately 70% of all CRC cases are sporadic in nature, 20%-25% have familial aggregation and only < 5% is hereditary in origin. Identification of individuals with hereditary predi lection for CRC is critical, as it has an impact on their overall surgical mana gement including surgical timing, approach & technique and determines the role of prophylactic surgery and outcome. This review highlights the concept of hereditary CRC, provides insight into its molecular basis, possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management, based on the available international guidelines. 相似文献
2.
Renuka V. Iyer MD Bhavana Konda MD MPH Christos Fountzilas MD Sarbajit Mukherjee MD MS Dwight Owen MD MS Kristopher Attwood PhD Chong Wang MA Orla Maguire PhD Hans Minderman PhD Sheryl-Ann Suffren BA Karen Hicks BS John Wilton PhD Robert Bies PhD Danielle Casucci BA Diane Reidy-Lagunes MD Manisha Shah MD 《Cancer》2020,126(16):3689-3697
3.
Rimesh Pal Naresh Sachdeva Soham Mukherjee Vikas Suri Deepy Zohmangaihi Sant Ram Goverdhan Dutt Puri Ashish Bhalla Shiv Lal Soni Navin Pandey Anil Bhansali Sanjay Kumar Bhadada 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):193-196
Background and aimsPatients with diabetes mellitus (DM) often demonstrate impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and without type 2 diabetes mellitus (T2DM).MethodsRecords of non-severe COVID-19 patients admitted at our institution between April 10, 2020 and May 20, 2020 were retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody was performed using electrochemiluminescence immunoassay in plasma samples collected at least 14 days post-polymerase chain reaction (PCR) confirmation of diagnosis.ResultsThirty-one non-severe COVID-19 patients were included. Nine patients (29%) had T2DM with mean HbA1c at admission of 8.3 ± 1.0%. Anti-SARS-CoV-2 antibody was estimated at a median of 16 (14–17) days post-PCR confirmation of COVID-19 diagnosis. Only three patients (10%) were seronegative, and all had T2DM. Patients with T2DM were more likely to have non-detectable anti-SARS-CoV-2 antibodies than those without DM (p = 0.019).ConclusionsCOVID-19 patients with T2DM may not undergo seroconversion even after two weeks of diagnosis. Impaired seroconversion could theoretically increase the risk of reinfections in patients with DM. However, the finding requires validation in large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in patients with and without DM. 相似文献
4.
Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti 《World journal of hepatology》2021,13(4):433-455
BACKGROUNDHepatobiliary diseases result in the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues which may contribute to an unfavorable prognosis.AIMTo discover and validate diagnostic biomarkers of cholestatic liver diseases based on the urinary BA profile.METHODSWe analyzed urine samples by liquid chromatography-tandem mass spectrometry and compared the urinary BA profile between 300 patients with hepatobiliary diseases vs 103 healthy controls by statistical analysis. The BA profile was characterized using BA indices, which quantifies the composition, metabolism, hydrophilicity, and toxicity of the BA profile. BA indices have much lower inter- and intra-individual variability compared to absolute concentrations of BA. In addition, BA indices demonstrate high area under the receiver operating characteristic curves, and changes of BA indices are associated with the risk of having a liver disease, which demonstrates their use as diagnostic biomarkers for cholestatic liver diseases.RESULTSTotal and individual BA concentrations were higher in all patients. The percentage of secondary BA (lithocholic acid and deoxycholic acid) was significantly lower, while the percentage of primary BA (chenodeoxycholic acid, cholic acid, and hyocholic acid) was markedly higher in patients compared to controls. In addition, the percentage of taurine-amidation was higher in patients than controls. The increase in the non-12α-OH BA was more profound than 12α-OH BA (cholic acid and deoxycholic acid) causing a decrease in the 12α-OH/ non-12α-OH ratio in patients. This trend was stronger in patients with more advanced liver diseases as reflected by the model for end-stage liver disease score and the presence of hepatic decompensation. The percentage of sulfation was also higher in patients with more severe forms of liver diseases.CONCLUSIONBA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases. 相似文献
5.
In addition to camouflage and chemical toxicity, many caterpillars defend themselves against predators with sudden sharp movements. For smaller species, these movements propel the body away from the threat, but in larger caterpillars, such as the tobacco hornworm, Manduca sexta, the movement is a defensive strike targeted to a noxious stimulus on the abdomen. Previously, strikes have been studied using mechanical stimulation like poking or pinching the insect, but such stimuli are hard to control. They also introduce mechanical perturbations that interfere with measurements of the behavior. We have now established that strike behavior can be evoked using infra-red lasers to provide a highly localized and repeatable heat stimulus. The latency from the end of an effective stimulus to the start of head movement decreased with repeated stimuli and this effect generalized to other stimulus locations indicating a centrally mediated component of sensitization. The tendency to strike increased with two successive subthreshold stimuli. When delivered to different locations or to a single site, this split-pulse stimulation revealed an additional site-specific sensitization that has not previously been described in Manduca. Previous work shows that strong stimuli increases the effectiveness of sensory stimulation by activating a long-lasting muscarinic cation current in motoneurons. Injection of muscarinic cholinergic antagonists, scopolamine methyl bromide or quinuclidinyl benzilate, only decreased the strike probability evoked by paired stimuli at two locations and not at a single site. This strongly suggests a role of muscarinic acetylcholine receptors in the generalized sensitization of nociceptive responses in caterpillars. 相似文献
6.
7.
8.
9.
10.