首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   78707篇
  免费   5933篇
  国内免费   246篇
耳鼻咽喉   915篇
儿科学   2044篇
妇产科学   1112篇
基础医学   10613篇
口腔科学   888篇
临床医学   8280篇
内科学   16644篇
皮肤病学   983篇
神经病学   7619篇
特种医学   3037篇
外科学   12828篇
综合类   885篇
一般理论   93篇
预防医学   5939篇
眼科学   1948篇
药学   5416篇
中国医学   96篇
肿瘤学   5546篇
  2023年   609篇
  2022年   403篇
  2021年   1911篇
  2020年   1345篇
  2019年   2196篇
  2018年   2525篇
  2017年   1825篇
  2016年   1884篇
  2015年   2213篇
  2014年   3221篇
  2013年   4081篇
  2012年   6550篇
  2011年   6779篇
  2010年   3695篇
  2009年   3248篇
  2008年   5425篇
  2007年   5634篇
  2006年   5229篇
  2005年   5169篇
  2004年   4677篇
  2003年   4278篇
  2002年   3875篇
  2001年   628篇
  2000年   427篇
  1999年   547篇
  1998年   677篇
  1997年   477篇
  1996年   392篇
  1995年   428篇
  1994年   400篇
  1993年   390篇
  1992年   266篇
  1991年   228篇
  1990年   212篇
  1989年   191篇
  1988年   167篇
  1987年   148篇
  1986年   148篇
  1985年   162篇
  1984年   189篇
  1983年   156篇
  1982年   243篇
  1981年   237篇
  1980年   184篇
  1979年   111篇
  1978年   123篇
  1977年   106篇
  1976年   82篇
  1975年   78篇
  1974年   65篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
European Journal of Epidemiology - With the rising use of machine learning for healthcare applications, practitioners are increasingly confronted with the limitations of prediction models that are...  相似文献   
3.
4.

Background

During coronavirus disease 2019 (COVID-19)–related operating room closures, some multidisciplinary thoracic oncology teams adopted a paradigm of stereotactic ablative radiotherapy (SABR) as a bridge to surgery, an approach called SABR-BRIDGE. This study presents the preliminary surgical and pathological results.

Methods

Eligible participants from four institutions (three in Canada and one in the United States) had early-stage presumed or biopsy-proven lung malignancy that would normally be surgically resected. SABR was delivered using standard institutional guidelines, with surgery >3 months following SABR with standardized pathologic assessment. Pathological complete response (pCR) was defined as absence of viable cancer. Major pathologic response (MPR) was defined as ≤10% viable tissue.

Results

Seventy-two patients underwent SABR. Most common SABR regimens were 34 Gy/1 (29%, n = 21), 48 Gy/3–4 (26%, n = 19), and 50/55 Gy/5 (22%, n = 16). SABR was well-tolerated, with one grade 5 toxicity (death 10 days after SABR with COVID-19) and five grade 2–3 toxicities. Following SABR, 26 patients underwent resection thus far (13 pending surgery). Median time-to-surgery was 4.5 months post-SABR (range, 2–17.5 months). Surgery was reported as being more difficult because of SABR in 38% (n = 10) of cases. Thirteen patients (50%) had pCR and 19 (73%) had MPR. Rates of pCR trended higher in patients operated on at earlier time points (75% if within 3 months, 50% if 3–6 months, and 33% if ≥6 months; p = .069). In the exploratory best-case scenario analysis, pCR rate does not exceed 82%.

Conclusions

The SABR-BRIDGE approach allowed for delivery of treatment during a period of operating room closure and was well-tolerated. Even in the best-case scenario, pCR rate does not exceed 82%.  相似文献   
5.
The UK islet allotransplant program is nationally funded to deliver one or two transplants over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia. Analyses were undertaken 10 years after program inception to evaluate associations between transplanted mass; single versus two transplants; time between two transplants and graft survival (stimulated C-peptide >50 pmol/L) and function. In total, 84 islet transplant recipients were studied. Uninterrupted graft survival over 12 months was attained in 23 (68%) single and 47 (94%) (p = .002) two transplant recipients (separated by [median (IQR)] 6 (3–8) months). 64% recipients of one or two transplants with uninterrupted function at 12 months sustained graft function at 6 years. Total transplanted mass was associated with Mixed Meal Tolerance Test stimulated C-peptide at 12 months (p < .01). Despite 1.9-fold greater transplanted mass in recipients of two versus one islet infusion (12 218 [9291–15 417] vs. 6442 [5156–7639] IEQ/kg; p < .0001), stimulated C-peptide was not significantly higher. Shorter time between transplants was associated with greater insulin dose reduction at 12 months (beta ?0.35; p = .02). Graft survival over the first 12 months was greater in recipients of two versus one islet transplant in the UK program, although function at 1 and 6 years was comparable. Minimizing the interval between 2 islet infusions may maximize cumulative impact on graft function.  相似文献   
6.
7.
8.
Journal of Molecular Medicine - Chronic exposure to high levels of particulate matter (PM) is correlated to a higher prevalence of cardio-metabolic disturbances. Adipose tissue represents a pivotal...  相似文献   
9.
European Journal of Orthopaedic Surgery & Traumatology - The management of limb-length discrepancy secondary to traumatic femoral bone loss poses a unique challenge for surgeons. The Ilizarov...  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号