南五味子伪品火棘果的鉴别

~~南五味子伪品火棘果的鉴别@李静$杭州市中医院!浙江杭州310007 @胡晓炜$杭州市药品检验所!浙江杭州310014 @宋旭峰$杭州市药品检验所!浙江杭州310014     

Therapeutic effect of 5-FC on YCD modified murine P388 leukemia in vivo

Cytosine deaminases (CDs) in bacteria andfungi are found to deaminate prodrug 5 - FC intocytotoxic agent 5 - FU .Yeast CD (YCD) is clonedfrom Saccharomyces cerevisiae.It has been shownpreviously that YCD was more efficient inconversing5 - FC than bacterial CD(b CD) [1-3 ] .As anovel suicide gene therapy system,YCD/ 5 - Fcsystem may be promising in cancer therapy andprevention of graft versus host disease.In thepresent study,we established a P388/ DBA murineleukemia model by infusin…     

铁皮枫斗超细粉碎的提取工艺研究

石斛是我国传统名贵中药,有滋阴清热,养胃生津的功效.在"神农本草经"中列为上品,可分为铁皮、黄草、金钗、霍山、环草、马鞭等数十个品种,其中铁皮石斛(D. candidum Wall.ex Lindl.)(干品又称铁皮枫斗)最为珍贵,是石斛中的极品.     

咽前进路切除舌根部异位甲状腺伴甲状腺瘤1例

病人女,24岁。因吞咽困难,夜间打鼾,有时憋醒,病程5年,加重1年入院。检查,舌根部有一肿物约3.5cm×3.5cm×2.5cm,呈淡粉色。肿物前界达轮廓乳头,后界达会厌溪上方,两侧距舌缘约0.8cm,触之较硬不搏动,基底固定,边界清,舌运动不受限。放射性核素~(131)I扫描及活检证实为舌根部异位甲状腺。颈部甲状腺形态和功能正常。决定手术切除肿物。     

检测血清VEGF、CEA、TSGF在肿瘤中的临床意义

目的研究血清VEGF、CEA在肿瘤诊断中联合应用价值以及肿瘤患者中血清VEGF与TSGF相关性.方法收集结直肠癌、肺癌患者以及正常人静脉血标本,ELISA法检测血清VEGF含量,放射免疫法检测CEA,化学显色法检测TSGF.结果结直肠癌患者中,血清CEA阳性率为32.4%,VEGF阳性率为54.1%,两者联合应用时阳性率为73.0%.血清VEGF与TSCF在结直肠癌中的相关系数为r=0.355(P＜0.01),肺癌患者中为r=0.612(P＜0.05).结论联合检测CEA和VEGF可以明显提高结直肠癌患者的阳性率,肿瘤患者血清中VEGF与TSGF的含量显著相关.     

箭叶淫羊藿叶水提取液抗心律失常作用的研究

目的：了解箭叶淫羊藿叶（Epimedium Breuicornum Maxin EBM)水提取液的抗心律失常作用。方法：常规抗心律失常的方法。结果：箭叶淫羊藿叶水提取液对氯仿诱发的小鼠室颤，氯化钙诱发的大鼠室颤均有明显的预防作用，对乌头碱诱发的大鼠心律失常有明显的治疗效果。但不能对抗肾上腺素诱发的家兔心律失常。箭叶淫羊藿叶水提取液可降低蟾蜍离体坐骨神经动作电位。结论：提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na^ ,Ca^2 内流有关。进一步提示箭叶淫羊藿叶水提取液抗心律失常作用可能与其抑制Na^ ，内流有关。而与阻断β－肾上腺素受体无关。     

泉居沙雷菌产超广谱β-内酰胺酶的检测与分析

泉居沙雷菌是一种条件致病菌 ,以往在临床标本中很少检出 ,但近期我们在脓液及痰标本中培养出两株 ,且均产生超广谱 β 内酰胺酶 (ＥＳＢＬｓ) ,现报告始下 :1　材料与方法1.1　标本来源2例均为我院住院患者。例 1骨科患者 ,男 ,32岁 ,农民 ,右下肢广泛复合外伤 ,取脓性分泌物培养 ;例 2血液科患者 ,女 ,4 6岁 ,干部 ,急性白血病 ,因上呼吸道感染送痰及咽拭子培养。1.2　培养基Ｍ Ｈ琼脂干粉购自法国生物梅里埃公司 ,本实验室自配平板。1.3　药敏纸片氨苄西林 (Ａｍｐｉｃｉｌｌｉｎ)、头孢噻肟 (Ｃｅｆｏｔａｘｉｍｅ)、头孢他啶 (Ｃｅｆｔ…     

Epidemiological and pathogenic study on the outbreak of toxic shock syndrome and meningocephalitis caused by swine streptococcus

Objective: To reveal the relationship between the biological characteristics of pathogen and the pig-to-human spread of the epidemic and infectious disease in 1998 in East China. Methods: Epidemiological survey, pathological examination of pigs and patients, and pathogen isolation were performed. Results: The disease had a character of quick onset, serious symptoms, short course and high mortality. The clinical manifestations and pathological changes of the disease were high fever, sometimes with nausea, vomiting and diarrhea, then might develop to myositis, fascitis, DIC, multiple organ failure, shock and usually died in 2-3 d. Among 25 patients, 16 manifested clinically as streptococcal toxic shock syndromes and 9 streptococcal meningiocephalitis syndrome. The mortality was 81.25% and 11.11% respectively. Pathogenic bacteria isolated from diseased pigs and patients were found to have some common characteristics in morphology, staining and biological characters. Conclusion: The pathogen isolated from the blood of patients and pigs were identified as streptococci.     

中药混乱品种鉴别研究——7. 蕲蛇及其混淆品鉴别之二

作者前已报道蕲蛇及其伪品滑鼠蛇的鉴别,又据报道有些省发现蕲蛇商品药材中混有烙铁头、山烙铁头两种蛇的干燥体。作者对这两种混淆品与蕲蛇在体表花纹、鳞片以及骨骼的形态与组织特征等方面进行了鉴别研究。     

金樱根醇提取液耐缺氧作用的研究

目的：研究金樱根醇提取液的耐缺氧作用。方法：采用常压耐缺氧法、对抗特异性心肌缺氧法、对抗脑缺血缺氧法、游泳实验法观察金樱根醇提取液对小鼠存活时间的影响。结果：金樱根醇提取液明显延长小鼠常压缺氧、特异性心肌缺氧、脑缺血缺氧及游泳的存活时间。结论：金樱根醇提取液有显著耐缺氧作用。