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Wojtynek Nicholas E. Olson Madeline T. Bielecki Timothy A. An Wei Bhat Aaqib M. Band Hamid Lauer Scott R. Silva-Lopez Edibaldo Mohs Aaron M. 《Molecular imaging and biology》2020,22(4):891-903
Molecular Imaging and Biology - Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability... 相似文献
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Bowen Qi Ayrianne J. Crawford Nicholas E. Wojtynek Megan B. Holmes Joshua J. Souchek Graca Almeida-Porada Quan P. Ly Samuel M. Cohen Michael A. Hollingsworth Aaron M. Mohs 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(3):769-780
Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. In this study, hyaluronic acid derived nanoparticles with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG was not cytotoxic to healthy pancreatic epithelial cells and did not induce chemotaxis or phagocytosis, it accumulated significantly within the pancreas in an orthotopic pancreatic ductal adenocarcinoma model, and demonstrated contrast-enhancement for pancreatic lesions relative to non-diseased portions of the pancreas. Fluorescence microscopy showed higher fluorescence intensity in pancreatic lesions and splenic metastases due to NanoICG compared to ICG alone. The in vivo safety profile of NanoICG, including, biochemical, hematological, and pathological analysis of NanoICG-treated healthy mice, indicates negligible toxicity. These results suggest that NanoICG is a promising contrast agent for intraoperative detection of pancreatic tumors. 相似文献
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Byrka-Owczarek K Steplewska-Mazur K Krasoń M Bohosiewicz J Koszutski T Wojtynek G 《Journal of pediatric surgery》2004,39(8):1226-1229
Purpose
The aim of this study was to ascertain the possibility of diminishing ischemia-reperfusion injury by intravenous application of the chosen antioxidants: vitamin C, mannitol, and N-acetylcysteine.Methods
The study was performed on New Zealand Red male rabbits, which were divided into 6 groups of 8. In group 1, 5 segments of the small intestine were taken for histopathologic examination (normal intestine). In group 2, segments of the small intestine were taken for histopathologic examination after 3 hours of closure of the superior mesenteric artery (ischemic intestine). In group 3, after 3 hours of closure of the superior mesenteric artery, 1 hour of reperfusion took place. In this group, blood flow in the superior mesenteric artery was measured within the first 30 minutes, and segments of the small intestine were taken for histopathologic examination after 60 minutes of the reperfusion. In groups 4, 5, and 6 the procedure was similar to that in group 3, but additionally the rabbits were given antioxidants intravenously: in group 4, vitamin C, 250 mg/kg; in group 5, 20% mannitol, 3 mL/kg; and in group 6, N-acetylcysteine, 100 mg/kg.Results
All the chosen antioxidants had a beneficial influence on the blood flow in the superior mesenteric artery. The blood flow in the groups with antioxidants after 30 minutes of the reperfusion was 53% to 57% of initial values compared with 27% of initial values in group 3. In histopathologic evaluation, protective action of the antioxidants was seen in the groups with vitamin C and mannitol.Conclusions
Application of the chosen antioxidants reduces injury of the rabbit small intestine caused by reperfusion after 3 hours of closure of the superior mesenteric artery. 相似文献8.
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