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排序方式: 共有952条查询结果,搜索用时 15 毫秒
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Kazumi Taguchi Sung Yong Cho Anthony CF Ng Manint Usawachintachit Yung‐Khan Tan Yao Liang Deng Cheng‐Huang Shen Prem Gyawali Husain Alenezi Abbas Basiri Sopheap Bou Tarmono Djojodemedjo Kemal Sarica Lei Shi Praveen Singam Shrawan Kumar Singh Takahiro Yasui 《International journal of urology》2019,26(7):688-709
The Urological Association of Asia, consisting of 25 member associations and one affiliated member since its foundation in 1990, has planned to develop Asian guidelines for all urological fields. The field of stone diseases is the third of its guideline projects. Because of the different climates, and social, economic and ethnic environments, the clinical practice for urinary stone diseases widely varies among the Asian countries. The committee members of the Urological Association of Asia on the clinical guidelines for urinary stone disease carried out a surveillance study to better understand the diversity of the treatment strategy among different regions and subsequent systematic literature review through PubMed and MEDLINE database between 1966 and 2017. Levels of evidence and grades of recommendation for each management were decided according to the relevant strategy. Each clinical question and answer were thoroughly reviewed and discussed by all committee members and their colleagues, with suggestions from expert representatives of the American Urological Association and European Association of Urology. However, we focused on the pragmatic care of patients and our own evidence throughout Asia, which included recent surgical trends, such as miniaturized percutaneous nephrolithotomy and endoscopic combined intrarenal surgery. This guideline covers all fields of stone diseases, from etiology to recurrence prevention. Here, we present a short summary of the first version of the guideline – consisting 43 clinical questions – and overview its key practical issues. 相似文献
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Vivek Ashoka Menon Elissa Tong Dana Rose-Marie Louise Slape Tai Anh Phan Renee CF Chan 《The Australasian journal of dermatology》2020,61(1):e97-e99
Dermatitis artefacta is a self-inflicted cutaneous disease presenting as sharply delineated ulcers, usually in accessible sites such as the head and neck. IgG4-related disease (IgG4-RD) is a recently recognised immune-mediated condition causing a fibroinflammatory process, resulting in the formation of tumefactive lesions in various organs, rarely presenting primarily in the skin. We report a case of cutaneous IgG4-RD clinically presenting as dermatitis artefacta. 相似文献
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Jean H. Siedel Kari L. Ring Wei Hu Robert L. Dood Ying Wang Keith Baggerly Kathleen M. Darcy Thomas P. Conrads Shannon Gallagher Placede Tshiaba Chris Neff Kirsten M. Timms Selanere Mangala Shannon N. Westin Russell Broaddus Gabriel Lopez-Berestein Karen H. Lu Robert L. Coleman Anil K. Sood 《Gynecologic oncology》2021,160(3):777-785
BackgroundHomologous recombination deficiency (HRD) score is related to chemotherapy response in some cancers, but its role in endometrial cancer in not known. We determined frequency and clinical significance of alterations in the HR pathway in endometrial cancer.Methods253 endometrioid endometrial adenocarcinoma (EEA) samples from two independent cohorts (discovery and replication) were tested for HRD score using the Myriad HRD assay, microsatellite instability (MSI) and tumor mutation burden (TMB) using a next generation sequencing assay. HRD scores were also generated on endometrial cancer cell lines and in vivo response to olaparib was assessed.ResultsROC curves were employed to determine optimal cutoffs of HRD in relation to survival impact in endometrial cancer and a cutoff of HRD ≥ 4 was suggested for DFS using the discovery cohort. Patients from two independent cohorts with HRD score ≥ 4 trended toward worse survival as compared to those with HRD score < 4. Both cohorts were further separated into four groups according to molecular subtypes (TMB positive; MSI positive; HRD positive; all others). When grouped by molecular subtype, there was a significant difference between groups using an HRD ≥4 cutoff in the initial (p = 0.0024) and replication (p = 0.042) cohorts. The Hec1a model (HRD score = 19) was highly sensitive to olaparib in in vitro and in vivo experiments.ConclusionsHigh HRD score was associated with worse DFS in our patient cohort. These findings suggest that HRD score may have clinical utility in patients with advanced or recurrent endometrial cancer. 相似文献
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Jinhan Xie MPharm PhD Amit Kumar PhD M. Emmy M. Dolman PhD Chelsea Mayoh BSc Dong-Anh Khuong-Quang MD PhD Roxanne Cadiz BSc Marie Wong-Erasmus PhD Emily V. A. Mould PhD Dylan Grebert-Wade BSc Paulette Barahona PhD Alvin Kamili BMedSc PhD Maria Tsoli PhD Timothy W. Failes PhD Shu-Oi Chow BSc Greg M. Arndt BSc PhD Kanika Bhatia MD Glenn M. Marshall AM MB BS MD FRACP David S. Ziegler MBBS BSc FRACP MD Michelle Haber AM PhD Hon DSc FAHMS Richard B. Lock BSc PhD Vanessa Tyrrell BAppSc MHGSA FHGSA MBA CSA ARCPA Loretta Lau MBBS MMed PhD FRACP Penny Athanasatos BAppSc CT CF Andrew J. Gifford BSc Hons PhD MBBS FRCPA 《Cancer cytopathology》2021,129(10):805-818
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Shuyang Yao Filip Janku Vivek Subbiah John Stewart Sapna Pradyuman Patel Ahmed Kaseb Shannon Neville Westin Aung Naing Apostolia Maria Tsimberidou David Hong Sarina Anne Piha-Paul Nai Shi Amanda Johnston John Bomalaski Siqing Fu 《British journal of cancer》2021,124(9):1533
Background Arginine depletion interferes with pyrimidine metabolism and DNA damage-repair pathways, and pairing arginine deiminase pegylated with 20,000-molecular-weight polyethylene glycol (ADI-PEG20) with platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs.Methods This single-centre, Phase 1 trial was conducted using a 3 + 3 dose escalation designed to assess safety, tolerability and determine the recommended Phase 2 dose (RP2D) of ADI-PEG20.Results We enrolled 99 patients with metastatic argininosuccinate synthetase 1 (ASS1) deficient malignancies. We observed no dose-limiting toxic effects or treatment-related mortality. Three percent of patients discontinued treatment because of toxicity. After treatment, 5% (5/99) of patients had partial responses, and 41% had stable disease. The median progression-free and overall survival durations were 3.62 and 8.06 months, respectively. Substantial arginine depletion and citrulline escalation persisted in most patients through weeks 24 and 8, respectively. Tumour responses were associated with anti-ADI-PEG20 antibody levels at weeks 8 and 16 (p = 0.031 and p = 0.0357, respectively).Conclusion Concurrently administered ADI-PEG20 and cisplatin had an acceptable safety profile and had shown antitumour activity against metastatic ASS1-deficient solid tumours. Further evaluation of this treatment combination is warranted.Subject terms: Cancer, Cancer therapy 相似文献
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Bisphosphonates are inhibitors of osteoclastic bone resorption with therapeutic benefit in a variety of bone disorders in both adults and children. While these agents have been routinely used in adults for the past three decades, their more recent introduction into paediatric medicine means there is a paucity of data on long‐term safety and effects on dental development. There is uncertainty regarding the dental management of children treated with bisphosphonates, particularly when invasive dental procedures, such as extractions and oral surgical procedures, are required. There are limited data with which to make recommendations about the dental management of patients treated with bisphosphonates, and there are no published recommendations that specifically address paediatric patients. This paper aims to outline paediatric uses and adverse effects of bisphosphonates and present recommendations on the dental management of children receiving bisphosphonates. 相似文献
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Shannon N. Westin Zhenlin Ju Russell R. Broaddus Camilla Krakstad Jane Li Navdeep Pal Karen H. Lu Robert L. Coleman Bryan T. Hennessy Samuel J. Klempner Henrica M.J. Werner Helga B. Salvesen Lewis C. Cantley Gordon B. Mills Andrea P. Myers 《Molecular oncology》2015,9(8):1694-1703
Endometrial cancer incidence is increasing, due in part to a strong association with obesity. Mutations in the phosphatidylinositol 3‐kinase (PI3K) pathway, the central relay pathway of insulin signals, occur in the majority of endometrioid adenocarcinomas, the most common form of endometrial cancer. We sought to determine the impact of PI3K pathway alterations on progression free survival in a cohort of endometrioid endometrial cancers. Prognostic utility of PIK3CA, PIK3R1, and PTEN mutations, as well as PTEN protein loss by immunohistochemistry, was explored in the context of patient body mass index. Reverse‐phase protein arrays were utilized to assess protein expression based on PTEN status. Among 187 endometrioid endometrial cancers, there were no statistically significant associations between PFS and PIK3CA, PIK3R1, PTEN mutation or loss. When stratified by body mass index, PTEN loss was associated with improved progression free survival (P < 0.006) in obese (body mass index ≥ 30) patients. PTEN loss resulted in distinct protein changes: Canonical PI3K pathway activation was observed only in the non‐obese population while decreased expression of β‐CATENIN and phosphorylated FOXO3A was observed in obese patients. These data suggest the impact of PTEN loss on tumor biology and clinical outcomes must be interpreted in the context of body mass index, and provide a potential explanation for discrepant reports on the effect of PTEN status and obesity on prognosis in endometrial cancer. This reveals a clinically important interaction between metabolic state and tumor genetics that may unveil the biologic underpinning of obesity‐related cancers and impact ongoing clinical trials with PI3K pathway inhibitors. 相似文献