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1.
Veronika Vilgis Shawn A. Rhoads David G. Weissman Kristina L. Gelardi Erika E. Forbes Alison E. Hipwell Kate Keenan Paul D. Hastings Amanda E. Guyer 《Human brain mapping》2020,41(3):739-754
Functional neuroimaging results need to replicate to inform sound models of human social cognition and its neural correlates. Introspection, the capacity to reflect on one's thoughts and feelings, is one process required for normative social cognition and emotional functioning. Engaging in introspection draws on a network of brain regions including medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), middle temporal gyri (MTG), and temporoparietal junction (TPJ). Maturation of these regions during adolescence mirrors the behavioral advances seen in adolescent social cognition, but the neural correlates of introspection in adolescence need to replicate to confirm their generalizability and role as a possible mechanism. The current study investigated whether reflecting upon one's own feelings of sadness would activate and replicate similar brain regions in two independent samples of adolescents. Participants included 156 adolescents (50% female) from the California Families Project and 119 adolescent girls from the Pittsburgh Girls Study of Emotion. All participants completed the Emotion Regulation Questionnaire (ERQ) and underwent a functional magnetic resonance imaging scan while completing the same facial emotion‐processing task at age 16–17 years. Both samples showed similar whole‐brain activation patterns when engaged in sadness introspection and when judging a nonemotional facial feature. Whole‐brain activation was unrelated to ERQ scores in both samples. Neural responsivity to task manipulations replicated in regions recruited for socio‐emotional (mPFC, PCC, MTG, TPJ) and attention (dorsolateral PFC, precentral gyri, superior occipital gyrus, superior parietal lobule) processing. These findings demonstrate robust replication of neural engagement during sadness introspection in two independent adolescent samples. 相似文献
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Iñaki Comino-Méndez Luis J Leandro-García Guillermo Montoya Lucía Inglada-Pérez Aguirre A. de Cubas María Currás-Freixes Carolyn Tysoe Louise Izatt Rocío Letón Álvaro Gómez-Graña Veronika Mancikova María Apellániz-Ruiz Massimo Mannelli Francesca Schiavi Judith Favier Anne-Paule Gimenez-Roqueplo Henri J. L. M. Timmers Giovanna Roncador Juan F. Garcia Cristina Rodríguez-Antona Mercedes Robledo Alberto Cascón 《Journal of molecular medicine (Berlin, Germany)》2015,93(11):1247-1255
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Univ.Prof. Dr. Heinz Ludwig Dr. Rayko Evstatiev Univ.Prof. Dr. Gabriela Kornek Univ.Prof. Dr. Matti Aapro Univ.Prof. Dr. Thomas Bauernhofer Dr. Veronika Buxhofer-Ausch Univ.Prof. Dr. Michael Fridrik Univ.Prof. Dr. Dietmar Geissler Univ.Prof. Dr. Klaus Geissler Univ.Prof. Dr. Heinz Gisslinger Dr. Elisabeth Koller Dr. Gerhard Kopetzky Dr. Alois Lang Priv.Doz. Dr. Holger Rumpold Univ.Prof. Dr. Michael Steurer Dr. Houman Kamali Univ.Prof. Dr. Hartmut Link 《Wiener klinische Wochenschrift》2015,127(23-24):907-919
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Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma
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Raul Zamora-Ros Valerie Cayssials Mazda Jenab Joseph A. Rothwell Veronika Fedirko Krasimira Aleksandrova Anne Tjønneland Cecilie Kyrø Kim Overvad Marie-Christine Boutron-Ruault Franck Carbonnel Yahya Mahamat-Saleh Rudolf Kaaks Tilman Kühn Heiner Boeing Antonia Trichopoulou Elissavet Valanou Effie Vasilopoulou Giovanna Masala Valeria Pala Salvatore Panico Rosario Tumino Fulvio Ricceri Elisabete Weiderpass Torkjel M. Sandanger Cristina Lasheras Antonio Agudo Maria-Jose Sánchez Pilar Amiano Carmen Navarro Eva Ardanaz Emily Sonestedt Bodil Ohlsson Lena Maria Nilsson Martin Rutegård Bas Bueno-de-Mesquita Kay-Thee Khaw Nicholas J. Wareham Kathryn Bradbury Heinz Freisling Isabelle Romieu Amanda J. Cross Paolo Vineis Augustin Scalbert 《European journal of epidemiology》2018,33(11):1063-1075
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2?=?1.06, 95% CI 0.99–1.14) or in men (HRlog2?=?0.97, 95% CI 0.90–1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2?=?0.91, 95% CI 0.85–0.97) and positively associated with rectal cancer in women (HRlog2?=?1.10, 95% CI 1.02–1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women. 相似文献
8.
Ankit J. Kansagra Noelle V. Frey Merav Bar Theodore W. Laetsch Paul A. Carpenter Bipin N. Savani Helen E. Heslop Catherine M. Bollard Krishna V. Komanduri Dennis A. Gastineau Christian Chabannon Miguel A. Perales Michael Hudecek Mahmoud Aljurf Leslie Andritsos John A. Barrett Veronika Bachanova Chiara Bonini Shahrukh K. Hashmi 《Biology of blood and marrow transplantation》2019,25(3):e76-e85
On August 30, 2017 the US Food and Drug Administration approved tisagenlecleucel (Kymriah; Novartis, Basel, Switzerland), a synthetic bioimmune product of anti-CD19 chimeric antigen receptor T cells (CAR-T), for the treatment of children and young adults with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). With this new era of personalized cancer immunotherapy, multiple challenges are present, ranging from implementation of a CAR-T program to safe delivery of the drug, long-term toxicity monitoring, and disease assessments. To address these issues experts representing the American Society for Blood and Marrow Transplant, the European Society for Blood and Marrow Transplantation, the International Society of Cell and Gene Therapy, and the Foundation for the Accreditation of Cellular Therapy formed a global CAR-T task force to identify and address key questions pertinent for hematologists and transplant physicians regarding the clinical use of anti CD19 CAR-T therapy in patients with B-ALL. This article presents an initial roadmap for navigating common clinical practice scenarios that will become more prevalent now that the first commercially available CAR-T product for B-ALL has been approved. 相似文献
9.
Erica Dahl Warlick Todd E. DeFor Nelli Bejanyan Shernan Holtan Margaret MacMillan Bruce R. Blazar Kathryn Dusenbery Mukta Arora Veronika Bachanova Sarah Cooley Aleksandr Lazaryan Philip McGlave Jeffrey S Miller Armin Rashidi Arne Slungaard Gregory Vercellotti Celalettin Ustun Claudio Brunsein Daniel Weisdorf 《Biology of blood and marrow transplantation》2019,25(1):56-62
Reduced-intensity conditioning (RIC) extends the curative potential of allogeneic hematopoietic cell transplantation (HCT) to patients with hematologic malignancies unable to withstand myeloablative conditioning. We prospectively analyzed the outcomes of 292 consecutive patients, median age 58 years (range, 19 to 75) with hematologic malignancies treated with a uniform RIC regimen of cyclophosphamide, fludarabine, and total body irradiation (200 cGy) with or without antithymocyte globulin and cyclosporine and mycophenolate mofetil graft-versus-host disease (GVHD) prophylaxis followed by allogeneic HCT at the University of Minnesota from 2002 to 6. Probability of 5-year overall survival was 78% for patients with indolent non-Hodgkin lymphoma, 53% for chronic myelogenous leukemia, 55% for Hodgkin lymphoma, 40% for acute myelogenous leukemia, 37% for myelodysplastic syndrome, 29% for myeloma, and 14% for myeloproliferative neoplasms. Corresponding outcomes for relapse were 0%, 13%, 53%, 37%, 39%, 75%, and 29%, respectively. Disease risk index (DRI) predicted both survival and relapse with superior survival (64%) and lowest relapse (16%) in those with low risk score compared with 24% survival and 57% relapse in those with high/very-high risk scores. Recipient cytomegalovirus (CMV)-positive serostatus was protective from relapse with the lowest rates in those also receiving a CMV-positive donor graft (29%). The cumulative incidence of 2-year nonrelapse mortality was 26% and was lowest in those receiving a matched sibling graft at 21%, with low (21%) or intermediate (18%) HCT-specific comorbidity index, and was similar across age groups. The incidence of grades II to IV acute GVHD was 43% and grades III to IV 27%; the highest rates were found in those receiving an unrelated donor (URD) peripheral blood stem cell (PBSC) graft, at 50%. Chronic GVHD at 1 year was 36%.Future approaches incorporating alternative GVHD prophylaxis, particularly for URD PBSC grafts, and targeted post-transplant antineoplastic therapies for those with high DRI are indicated to improve these outcomes. 相似文献
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