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1.
2.
Pure prostatic leiomyoma is very rare. We report a case of magnetic resonance imaging findings of prostatic leiomyoma. The mass was expansile and had a slightly higher signal intensity than skeletal muscle on T2-weighted images. Normal prostatic glandular tissue could be clearly distinguished from the tumor. 相似文献
3.
Risa Taira Sayori Yamaguchi Kyoko Shimizu Kiminori Nakamura Tokiyoshi Ayabe Toshio Taira 《Journal of Clinical Biochemistry and Nutrition》2015,56(2):149-154
Recent studies suggest a relationship between intestinal microbiota and metabolic syndromes; however, the underlying mechanism remains unclear. To clarify this issue, we assessed the effects of bacterial cell wall components on adiponectin, leptin and resistin secretion from rat visceral adipocytes in vitro. We also measured the relative population of Firmicutes and Bacteroidetes in fecal microbiota and the amount of fecal mucin as an intestinal barrier function, when mice were fed a high-fat diet. In the present study, we demonstrated that bacterial cell wall components affect the secretion of adipokines, depending on the presence of antigens from gram-positive or gram-negative bacteria. Lipopolysaccharide markedly inhibited adiponectin, leptin, and resistin secretion, whereas peptidoglycan increased adiponectin secretion and decreased resistin secretion in vitro. In vivo experiments showed that the high-fat diet increased the population of Firmicutes and decreased that of Bacteroidetes. In contrast, the high-fat diet downregulated the stool output and fecal mucin content. These results demonstrate that bacterial cell wall components affect the onset of metabolic syndromes by mediating the secretion of adipokines from visceral adipose tissue. Furthermore, we believe that metabolic endotoxemia is not due to the increasing dominance of gram-negative bacteria, Bacteroidetes, but due to the depression of intestinal barrier function. 相似文献
4.
Criado PR de Carvalho JF Ayabe LA Brandt HR Romiti R Maruta CW 《Rheumatology international》2012,32(8):2551-2555
Adult-onset Still’s disease (AOSD) patients typically present with arthralgia, fever, lymphadenopathy and a transient salmon maculopapular rash. Only approximately 25 cases of AOSD with urticaria were described in the literature. In this article, the authors report three additional cases of AOSD with urticarial and dermographic lesions who had a good clinical response to glucocorticoid and antihistamines. A review of the literature concerning this issue is also herein written. 相似文献
5.
Terada R Yasutake T Yamaguchi E Hisamatsu T Nakamura S Ayabe H Tagawa Y 《Journal of gastroenterology》1999,34(1):11-17
We investigated the correlation between the frequency of numerical aberrations of chromosome 17 and clinicopathological features
of gastric cancer. The copy number of chromosome 17 was examined with fluorescence in-situ hybridization (FISH) in frozen
specimens from 100 primary gastric cancers. Chromosomal numerical aberrations were diagnosed as chromosomal loss (single signal)
or gain (triple or more signals), in each cell. The frequency of numerical aberrations of chromosome 17 correlated significantly
with the depth of invasion (P < 0.01), lymph node metastasis (P < 0.0001), lymphatic invasion (P < 0.001), and venous invasion (P < 0.01). Numerical aberrations of chromosome 17 were associated with lymph node metastasis in 32 early gastric cancers. Multiple
regression analysis identified the depth of invasion and numerical aberrations of chromosome 17 as independent significant
determinants of lymph node metastasis. Our findings suggest that alterations in chromosome 17 may be linked with tumor progression
in primary gastric cancer.
Our results also indicate that numerical aberrations of chromosome 17 detected by FISH provide important information about
the malignant potential (in particular, lymph node metastasis) of primary gastric cancer.
(Received Feb. 22, 1998; accepted July 24, 1998) 相似文献
6.
Nanashima A Tanaka K Yamaguchi H Shibasaki S Morino S Yoshinaga M Sawai T Nakagoe T Ayabe H 《Digestive diseases and sciences》2003,48(8):1517-1522
This study was designed to provide a histopathological analysis focusing on fibrosis (staging) and necroinflammatory reaction (grading, hepatitis activity index: HAI) in noncancerous liver tissue, and mitotic index (MI) in cancerous liver tissue to predict prognosis in 81 patients with chronic hepatitis or cirrhosis who underwent hepatectomy for hepatocellular carcinoma (HCC). The incidence of grade 2/3 and higher HAI was higher in patients with viral hepatitis C. The incidence of grade 2/3 was associated with vascular invasion of HCC, postoperative liver dysfunction, and cancer recurrence. Higher MI (5) was significantly associated with vascular invasion, poor histological differentiation, and recurrence rate (P < 0.05). Multivariate analysis showed that higher grade was the factor strongly associated with cancer recurrence (odds ratio: 10.621, P = 0.006). Higher MI correlated with overall patient survival (P < 0.05) by univariate analysis. Grading and MI are the useful prognostic markers for predicting tumor recurrence and patient survival. 相似文献
7.
8.
Long-term outcome of percutaneous transluminal coronary angioplasty and coronary artery bypass grafting in patients with end-stage renal disease 总被引:1,自引:0,他引:1
Ohmoto Y Ayabe M Hara K Sugimoto T Tagawa H Fukuda S Suma H Wanibuchi Y Tamura T 《Japanese circulation journal》1999,63(12):981-987
This study was conducted to investigate therapeutic methods for end-stage renal disease (ESRD) by retrospectively analyzing in-hospital outcome and long-term outcome in patients who underwent either percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG). Ninety-two patients underwent PTCA and 47 underwent CABG, and the initial success rates were 87% and 85%, respectively. As major in-hospital complications, in the PTCA group 1 died (1%), 2 required emergency CABG (2%), and 2 had Q-wave myocardial infarction (2%); in the CABG group, 7 died (15%) and 3 had Q-wave myocardial infarction (6%). As for the long-term outcome, although there were no differences in the incidence of death or the incidence of cardiac death between the 2 groups, the cumulative proportion of patients free of death, myocardial infarction, CABG and repeat PTCA was lower in the PTCA group, which was mainly due to a higher incidence of repeat PTCA in that group. The incidence of cardiac death was low for both groups among the patients attaining complete revascularization. Twenty-three percent of the patients required cross-over implementation of PTCA and CABG. In conclusion, it is necessary to aim for complete revascularization using both treatments for a better prognosis in patients with ESRD. 相似文献
9.
Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients 总被引:6,自引:0,他引:6
Nakagoe T Nanashima A Sawai T Tuji T Ohbatake M Jibiki M Yamaguchi H Yasutake T Ayabe H Matuo T Tagawa Y 《Journal of cancer research and clinical oncology》2000,126(7):375-382
The deletion of blood group ABH isoantigens on tumor tissues has been reported to be an adverse prognostic marker for patients
with various solid tumors. In the present study, we evaluated the prognostic value of altered expression of ABH isoantigens
in colorectal carcinomas. Using monoclonal antibodies, the expression of A, B, and H antigens was assessed by immunohistochemistry
on paraffin-embedded carcinoma samples from 82 patients who had undergone surgery for colorectal cancer. ABH isoantigens were
found to be deleted in 36 carcinomas (43.9%) and expressed in 46 (56.1%). Univariate and multivariate analysis using a logistic
regression model revealed that N factor (lymph node metastasis) and blood group type were independently related to the expression
of ABH isoantigens. In contrast to previous reports on other cancers, patients whose colorectal carcinomas express ABH isoantigens
had a poorer prognosis than those whose carcinomas showed deletion of ABH isoantigens (P = 0.0008). The expression of ABH isoantigens was an independent prognostic variable, in addition to T (depth of tumor invasion),
N, and M (distant metastasis) factors, as shown by means of Cox regression analysis. In conclusion, the expression of ABH
isoantigens in carcinoma tissue is an important poor prognostic factor in patients with colorectal cancer. This variable needs
to be considered in the design of future trials of therapy.
Received: 20 August 1999 / Accepted: 16 December 1999 相似文献
10.
Yukio Yonemoto Koichi Okamura Kimihiko Takeuchi Keio Ayabe Tetsuya Kaneko Masatoshi Matsushita 《Modern rheumatology / the Japan Rheumatism Association》2016,26(1):24-28
Objective. The aim of this study was to compare the efficacy and safety of golimumab (GLM) 50 mg + methotrexate (MTX) combination therapy and GLM 100 mg monotherapy in patients with rheumatoid arthritis (RA).Methods. The subjects were 115 RA patients (92 females and 23 males; median (range) age, 64 (17–87) years; median (range) disease duration, 8 (0.6–48) years) started on GLM. Eighty-three patients received GLM 50 mg/4 weeks + MTX (C group; median (range) MTX dosage 8 (2–16) mg/week), and 32 patients received GLM 100 mg/4 weeks (M group).Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), matrix metalloproteinase-3, disease activity score (DAS) 28-ESR, DAS28-CRP, simplified disease activity index, and clinical disease activity index were evaluated 4, 12, and 24 weeks after starting GLM.Results. There were no significant differences in disease activity, adverse events, and drug continuation rates at 24 weeks between the groups. The DAS28-ESR remission rate was 34% in the C group and 26% in the M group.Conclusions. GLM 100 mg monotherapy improved disease activity as well as GLM 50 mg + MTX combination therapy. GLM 100 mg monotherapy appears to have a sufficient therapeutic effect in RA patients who cannot take MTX. 相似文献