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1.
Luis Hermenegildo Martín Arias Antonio Martín Gonzlez Rosario Sanz Fadrique Esther Salgueiro Vzquez 《Fundamental & clinical pharmacology》2019,33(2):134-147
Prior meta‐analyses have shown a higher gastrointestinal risk of nonselective NSAIDs versus placebo and a lower gastrointestinal risk of coxibs versus nonselective NSAIDs. However, the available data about gastrointestinal risk for coxibs versus placebo are scarce. The aim of this study was to review the current evidence on the use of coxibs and to evaluate the risk of gastrointestinal adverse outcomes (GAO) associated with coxibs versus nonexposed. Search was conducted on PubMed and Embase databases. We selected cohort observational, case‐control, nested case‐control and case‐crossover studies that reported the risk of GAO associated with coxibs versus nonexposed as relative risk (RR), odds ratio (OR), hazard ratio (HR) or incidence rate ratio (IRR). It was estimated the pooled RR and the 95% confidence interval (CI) for coxibs both individually and as a whole by the DerSimonian and Laird method. Twenty‐eight studies met inclusion criteria. Overall, coxibs were associated with a significant increment in the risk of GAO [RR 1.64 (95% CI 1.44–1.86)]. The analysis by individual drugs showed that etoricoxib [RR 4.85 (95% CI 2.64–8.93)] presented the highest gastrointestinal risk, followed by rofecoxib [RR 2.02 (95% CI 1.56–2.61)] and celecoxib [RR 1.53 (95% CI 1.19–1.97)]. Gastrointestinal risk was also high for the subgroups aged <65 years and low‐dose coxibs. The use of coxibs is associated with a statistically significant increased risk of GAO, which would be high even for low‐dose coxibs and <65‐year‐old subgroups. The risk would be higher for etoricoxib than for celecoxib and rofecoxib. 相似文献
2.
Miguel A. Sanz Pau Montesinos María F. Casale Joaquín Díaz-Mediavilla Santiago Jiménez Isolda Fernández Pascual Fernández José González-Campos José D. González Pilar Herrera Elena de Lisa Teresa Olave Rafael Rojas Olga Salamero María J. Sayas Antonio Pellicer Alfredo Perales 《Annals of hematology》2015,94(8):1357-1361
3.
Eva Barragán María Carmen Chillón Remedios Castelló-Cros Nerea Marcotegui María Isabel Prieto Montserrat Hoyos Raffaella Pippa Marta Llop Amaia Etxabe José Cervera Gabriela Rodríguez Ismael Bu?o José Rifón Jorge Sierra Marcos González María J. Calasanz Miguel A. Sanz María D. Odero 《Haematologica》2015,100(5):e183-e185
4.
5.
Juan D. Gonzalez‐Sanz 《Nursing philosophy》2020,21(4)
The current situation in which the humanities are disparaged affects all university disciplines, including nursing, in whose historical evolution the humanities have always been present in one form or another. Looking beyond this disrepute, this study proposes that nursing renew its attention to classical philosophy. Specifically, it invites a close reading of Xenophon's Anabasis and Plato's Meno, to get three related goals: to show how the use of ancient texts are very valuable tools for the philosophical initiation of nursing students and can help them reflect on their choice of nursing as a practical activity; to reflect on the problem of virtue and the nature of the good life; and to show how the interaction with ancient texts allows students to reflect on questions and issues of life, theirs and others, that are not open to investigation through a purely scientific method. Consequently, both Anabasis and Meno readings strengthen the intellectual relationship between philosophy and nursing, enabling the latter to delve deeper into the key questions of its own thought as a discipline. 相似文献
6.
R. Di Raimondo J. Sanz-Esporrn R. Pl I. Sanz-Martn F. Luengo F. Vignoletti J. Nuez Mariano Sanz 《Clinical oral investigations》2020,24(7):2351-2361
To evaluate the changes in alveolar contour after guided bone regeneration (GBR) with two different combinations of biomaterials in dehiscence defects arou 相似文献
7.
Miguel A. Sanz Pau Montesinos Haesook T. Kim Guillermo J. Ruiz-Argüelles María S. Undurraga María R. Uriarte Lem Martínez Rafael H. Jacomo Homero Gutiérrez-Aguirre Raul A. M. Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M. Fagundes Edo Vellenga Alexandra Holowiecka Ana J. González-Huerta Pascual Fernández Javier De la Serna Salut Brunet Elena De Lisa José González-Campos José M. Ribera Isabel Krsnik Arnold Ganser Nancy Berliner Raul C. Ribeiro Francesco Lo-Coco Bob L?wenberg Eduardo M. Rego 《Annals of hematology》2015,94(8):1347-1356
8.
Ellemarije Altena Clyne H. Bastien Ernesto J. Sanz‐Arigita Yannick Daviaux Stphanie Bioulac Jean‐Arthur Micoulaud‐Franchi Jacques Taillard Pierre Philip 《Journal of sleep research》2020,29(2)
Emotional reactivity in insomnia is affected both subjectively and on a physiological level for negative emotional material, but little is known about reactions to positive stimuli. We here investigated whether in younger adult insomnia patients, presentation of short humorous films would lead to heart rate decreases during and after film viewing, as compared to heart rate changes when falling asleep. Investigating 20 participants with DSM‐5‐diagnosed insomnia and 18 participants without insomnia, we found that heart rate decreased when falling asleep, increased when watching humorous films and returned to normal values afterwards for all participants. Film‐related heart rate increases were strongly related to humour ratings of the films. No differences were found between those with and without insomnia on subjective ratings of the films, film‐related heart rate changes or when falling asleep. We conclude that the experience of positive daily life stimuli in younger adults is not affected by insomnia in our study, despite insomnia having a known more profound effect on negative stimuli. Future studies exploring insomnia‐related autonomous nervous system responses combining different neurophysiological modalities should confirm our findings. 相似文献
9.
Ana Pardo Sanz PhD Ciro Santoro PhD Rocío Hinojar PhD Luisa Salido PhD Ez-Alddin Rajjoub MD Juan Manuel Monteagudo MD Ana García PhD Ariana González MD Rosana Hernández-Antolín PhD Ángel Sánchez Recalde PhD José Luis Zamorano PhD Covadonga Fernández-Golfín PhD 《Echocardiography (Mount Kisco, N.Y.)》2020,37(4):586-591
10.
Ramrez Caldern Jessie Z. Martnez Chamorro Elena Ibez Sanz Lan Albillos Merino Jos C. Borruel Nacenta Susana 《Emergency radiology》2021,28(3):613-620
Emergency Radiology - Gallbladder pathology is diverse, and imaging tests are essential tools for its diagnosis. Acute cholecystitis has multiple manifestations or complications, one of which is... 相似文献