全文获取类型
收费全文 | 9888篇 |
免费 | 702篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 93篇 |
儿科学 | 393篇 |
妇产科学 | 149篇 |
基础医学 | 1413篇 |
口腔科学 | 153篇 |
临床医学 | 888篇 |
内科学 | 1836篇 |
皮肤病学 | 201篇 |
神经病学 | 1113篇 |
特种医学 | 483篇 |
外国民族医学 | 5篇 |
外科学 | 1456篇 |
综合类 | 69篇 |
一般理论 | 6篇 |
预防医学 | 512篇 |
眼科学 | 229篇 |
药学 | 959篇 |
中国医学 | 3篇 |
肿瘤学 | 664篇 |
出版年
2021年 | 102篇 |
2019年 | 95篇 |
2018年 | 145篇 |
2017年 | 97篇 |
2016年 | 144篇 |
2015年 | 173篇 |
2014年 | 190篇 |
2013年 | 283篇 |
2012年 | 378篇 |
2011年 | 436篇 |
2010年 | 237篇 |
2009年 | 213篇 |
2008年 | 352篇 |
2007年 | 401篇 |
2006年 | 405篇 |
2005年 | 369篇 |
2004年 | 423篇 |
2003年 | 398篇 |
2002年 | 324篇 |
2001年 | 343篇 |
2000年 | 337篇 |
1999年 | 265篇 |
1998年 | 119篇 |
1997年 | 116篇 |
1996年 | 107篇 |
1995年 | 101篇 |
1994年 | 87篇 |
1993年 | 91篇 |
1992年 | 223篇 |
1991年 | 224篇 |
1990年 | 222篇 |
1989年 | 251篇 |
1988年 | 231篇 |
1987年 | 209篇 |
1986年 | 194篇 |
1985年 | 222篇 |
1984年 | 139篇 |
1983年 | 99篇 |
1982年 | 102篇 |
1981年 | 90篇 |
1980年 | 91篇 |
1979年 | 138篇 |
1978年 | 94篇 |
1977年 | 87篇 |
1976年 | 118篇 |
1975年 | 107篇 |
1974年 | 94篇 |
1973年 | 75篇 |
1971年 | 87篇 |
1970年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Hertler Caroline Eisele Günter Gramatzki Dorothee Seystahl Katharina Wolpert Fabian Roth Patrick Weller Michael 《Journal of neuro-oncology》2020,147(3):663-669
Journal of Neuro-Oncology - Gliomas are primary brain tumors with a life-limiting course of disease, and the last weeks of life are often characterized by neurological deficits that affect... 相似文献
3.
Christopher L. Heidler Eva K. Roth Markus Thiemann Claudia Blattmann Ramon L. Perez Peter E. Huber Michal Kovac Beate Amthor Gabriele Neu-Yilik Andreas E. Kulozik 《International journal of cancer. Journal international du cancer》2020,147(4):1059-1070
Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to study promising novel agents for the treatment of pediatric osteosarcoma. The checkpoint kinase (chk) inhibitor prexasertib (LY2606368) and its salt form (LSN2940930) have recently been shown to be active in adult and pediatric malignancies, including sarcoma. We have now tested the potency of prexasertib in clonogenic survival assays in two new lines of primary patient-derived osteosarcoma cells and in two established osteosarcoma cell lines as a single agent and in combination with cisplatin and the poly ADP-ribose polymerase (PARP) inhibitor talazoparib. Prexasertib alone results in strongly reduced clonogenic survival at low nanomolar concentrations and acts by affecting cell cycle progression, induction of apoptosis and induction of double-stranded DNA breakage at concentrations that are well below clinically tolerable and safe plasma concentrations. In combination with cisplatin and talazoparib, prexasertib acts in a synergistic fashion. Chk1 inhibition by prexasertib and its combination with the DNA damaging agent cisplatin and the PARP-inhibitor talazoparib thus emerges as a potential new treatment option for pediatric osteosarcoma which will now have to be tested in preclinical primary patient derived in vivo models and clinical studies. 相似文献
4.
5.
ABSTRACT Background: Motor deficits after stroke are a primary cause of long-term disability. The extent of functional recovery may be influenced by genetic polymorphisms. Objectives: Determine the effect of genetic polymorphisms for brain-derived neurotrophic factor (BDNF), catechol-O-methyltransferase (COMT), and apolipoprotein E (APOE) on walking speed, walking symmetry, and ankle motor control in individuals with chronic stroke. Methods: 38 participants with chronic stroke were compared based upon genetic polymorphisms for BDNF (presence [MET group] or absence [VAL group] of a Met allele), COMT (presence [MET group] or absence [VAL group] of a Met allele), and APOE (presence [ε4+ group] of absence [ε4- group] of ε4 allele). Comfortable and maximal walking speed were measured with the 10-m walk test. Gait spatiotemporal symmetry was measured with the GAITRite electronic mat; symmetry ratios were calculated for step length, step time, swing time, and stance time. Ankle motor control was measured as the accuracy of performing an ankle tracking task. Results: No significant differences were detected (p ≥ 0.11) between the BDNF, COMT, or APOE groups for any variables. Conclusions: In these preliminary findings, genetic polymorphisms for BDNF, COMT, and APOE do not appear to affect walking speed, walking symmetry, or ankle motor performance in chronic stroke. 相似文献
6.
Amy M. Berkman MD J. A. Livingston MD Kelly Merriman PhD Michelle Hildebrandt PhD Jian Wang PhD Seyedeh Dibaj PhD Jennifer McQuade MD Nancy You MD MHSc Anita Ying MD MBA Carlos Barcenas MD MSc Diane Bodurka MD MPH April DePombo DO Hun Ju Lee MD John de Groot MD Michael Roth MD 《Cancer》2020,126(16):3708-3718
7.
8.
Adam R. Roth 《Sociology of health & illness》2020,42(7):1642-1656
Late life is a period frequently marked by decline in personal health and heightened need for social support. Consequently, the social networks in which individuals are embedded assume an increasingly central role in the health and wellbeing of older adults. In the present article, I review the state of the literature on social networks and health in later life. By drawing on insights from the sociology of ageing and the life course, I address new developments and current challenges within the field. Chief among these developments and challenges is the recognition that the ageing process does not occur in a vacuum. Rather, individuals are consistently exposed to numerous changes to their social lives which have strong implications for current and future health outcomes. Upon highlighting the latest innovations within the field of networks and health, I conclude with useful directions for future research. 相似文献
9.
10.
Dominic Kaddu-Mulindwa Sophie Roth Aline Klees-Rollmann Klaus Fassbender Mathias Fousse 《Journal of neurovirology》2020,26(2):292-296
The development of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is often associated with neoplasia or infectious diseases as antibodies against neurons or synaptic proteins surface. A 30-year-old male patient was admitted to our department because of neurocognitive symptoms, particularly memory difficulties which had appeared a year prior and since then had been increasing. He had a medical history of smoking and hypertension. On examination, there were no focal neurological deficits. However, neuropsychological tests confirmed a lack of concentration and short-term memory impairment. Brain magnetic resonance imaging (MRI) and electroencephalography (EEG) remained unremarkable. Cerebrospinal fluid (CSF) analysis revealed a low lymphocytic pleocytosis without oligoclonal bands. Serum testing for human immunodeficiency virus (HIV) was positive with 420,000 HIV-1-RNA copies/ml. On a more detailed physical examination, a large number of purple patches were found on the entire body, which a biopsy confirmed to be Kaposi sarcoma (KS). A positive serum and CSF NMDA receptor antibody titer (serum 1:280; CSF 1:8) confirmed the diagnosis of an AIDS-associated anti-NMDA receptor encephalitis; therefore, we treated him with antiretroviral and immunosuppressive therapy. After 12 months, the KS lesions faded and the cognitive deficits improved slightly. Our case highlights that a detailed clinical examination and searching for neoplasia and/or an infection are helpful, though often neglected, tools for detecting an anti-NMDA receptor encephalitis. 相似文献