全文获取类型
收费全文 | 1160篇 |
免费 | 45篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 24篇 |
妇产科学 | 11篇 |
基础医学 | 101篇 |
口腔科学 | 6篇 |
临床医学 | 52篇 |
内科学 | 333篇 |
皮肤病学 | 4篇 |
神经病学 | 64篇 |
特种医学 | 29篇 |
外科学 | 353篇 |
综合类 | 5篇 |
预防医学 | 29篇 |
眼科学 | 23篇 |
药学 | 46篇 |
中国医学 | 2篇 |
肿瘤学 | 121篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 31篇 |
2020年 | 17篇 |
2019年 | 33篇 |
2018年 | 24篇 |
2017年 | 24篇 |
2016年 | 34篇 |
2015年 | 29篇 |
2014年 | 45篇 |
2013年 | 64篇 |
2012年 | 79篇 |
2011年 | 67篇 |
2010年 | 40篇 |
2009年 | 36篇 |
2008年 | 57篇 |
2007年 | 65篇 |
2006年 | 46篇 |
2005年 | 44篇 |
2004年 | 60篇 |
2003年 | 42篇 |
2002年 | 53篇 |
2001年 | 31篇 |
2000年 | 21篇 |
1999年 | 29篇 |
1998年 | 6篇 |
1997年 | 7篇 |
1996年 | 7篇 |
1995年 | 14篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 17篇 |
1991年 | 13篇 |
1990年 | 16篇 |
1989年 | 17篇 |
1988年 | 7篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 13篇 |
1983年 | 4篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 18篇 |
1977年 | 4篇 |
1975年 | 6篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1968年 | 4篇 |
1967年 | 3篇 |
排序方式: 共有1211条查询结果,搜索用时 15 毫秒
1.
2.
Kenny P. Pang FRCSEd FRCSI Claudio Vicini MD Filippo Montevecchi MD Ottavio Piccin MD MSc Sudipta Chandra MBBS MS Hyung C. Yang MD PhD Vikas Agrawal MS DLO Joseph C. K. Chung FRCS Yiong H. Chan BSc PhD Scott B. Pang Kathleen A. Pang Edward B. Pang Brian Rotenberg MD MPH FRCSC 《The Laryngoscope》2020,130(9):2281-2284
3.
Matthias May Luca Cindolo Richard Zigeuner Ottavio De Cobelli Bernardo Rocco Cosimo De Nunzio Andrea Tubaro Ioman Coman Michael Truss Orietta Dalpiaz Ingmar Wolff Bogdan Feciche Fabian Fenske Martin Pichler Luigi Schips Robert S. Figenshau Kerry Madison Manuel Sánchez-Chapado Sabine Brookman-May 《Urologic oncology》2014,32(8):1252-1258
ObjectivesTo analyze clinicopathological features and survival of surgically treated patients with renal cell carcinoma (RCC)≥80 years of age in comparison with patients between the ages of 60 and 70 years.Materials and methodsThe data for 2,516 patients with a median follow-up of 57 months were retrieved from a multinational database (Collaborative Research on Renal Neoplasms Association [CORONA]), including data for 6,234 consecutive patients with RCC after radical or partial nephrectomy. Comparative analysis of clinicopathological features of 241 octogenarians (3.9% of the database) and 2,275 reference patients between the ages of 60 and 70 years (36.5%) was performed. Multivariable regression analysis adjusted for competing risks was applied to identify the effect of advanced age on cancer-specific mortality (CSM) and other-cause mortality (OCM). Furthermore, instrumental variable analysis was employed to reduce residual confounding by unmeasured parameters.ResultsSignificantly more women were present (50% vs. 40%, P = 0.004), and significantly less often nephron-sparing surgery was performed in octogenarians compared with the reference group (11% vs. 20%, P<0.001). Although median tumor size and stages did not significantly defer, older patients less often had advanced or metastatic disease (N+/M1) (4.6% vs. 9.6%, P = 0.009). On multivariable analysis, higher CSM (hazard ratio = 1.48, P = 0.042) and OCM rates (hazard ratio = 4.32, P<0.001) were detectable in octogenarians (c-indices = 0.85 and 0.72, respectively). Integration of the variable age group in multivariable models significantly increased the predictive accuracy regarding OCM (6%, P<0.001), but not for CSM. Limitations are based on the retrospective study design.ConclusionsOctogenarian patients with RCC significantly differ in clinical features and display significantly higher CSM and OCM rates in comparison with their younger counterparts. 相似文献
4.
5.
6.
Neide Tomimura Costa Bruna Miglioranza Scavuzzi Tatiana Mayumi Veiga Iriyoda Marcell Alysson Batisti Lozovoy Daniela Frizon Alfieri Fabiano Aparecido de Medeiros Marcelo Cândido de Sá Pâmela Lonardoni Micheletti Bruno Alexandre Sekiguchi Edna Maria Vissoci Reiche Michael Maes Andréa Name Colado Simão Isaias Dichi 《Clinical and experimental medicine》2018,18(3):363-372
Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP). NOx and the NOx/TRAP ratio were significantly increased in RA, while no significant differences in lipid hydroperoxides, AOPP, UA, and TRAP levels were found between both groups. Treatment with leflunomide was associated with increased levels of carbonyl protein, and lowered levels in TRAP and UA, while the NOx/TRAP ratio further increased. NOx and the NOx/TRAP ratio were significantly higher in women than in men, while TRAP and UA were significantly lower in women. MetS was accompanied by increased AOPP and UA levels. RA was best predicted by increased NOx/TRAP ratio, CRP, and BMI. In conclusion, our data demonstrated that NOx and NOx/TRAP are strongly associated with RA physiopathology. Our findings suggest that inhibition of iNOS may become an interesting therapeutic approach for the treatment of RA. In addition, the presence of MetS and a decrease in levels of UA by leflunomide favor redox imbalance in RA patients. More studies are needed to evaluate the impact of antioxidant capacity reduction on RA progression. 相似文献
7.
Stefano Luzzago Ottavio de Cobelli Gabriele Cozzi Giulia Peveri Vincenzo Bagnardi Michele Catellani Ettore Di Trapani Francesco A. Mistretta Paola Pricolo Andrea Conti Sarah Alessi Giulia Marvaso Matteo Ferro Deliu-Victor Matei Giuseppe Renne Barbara Alicja Jereczek-Fossa Giuseppe Petralia Gennaro Musi 《BJU international》2020,126(1):104-113
8.
Arturo Ottavio Rinaldi Isabella Sanseverino Cristina Purificato Antonio Cortese Rosella Mechelli Silvia Francisci Marco Salvetti Enrico Millefiorini Sandra Gessani Maria Cristina Gauzzi 《Toxins》2015,7(1):129-137
Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS. 相似文献
9.
10.
Levi Gianfranco Signorini Costantino Tosoni Sandra Di Stefano Ottavio Cardone Giuseppe 《International Journal of Clinical & Laboratory Research》1985,15(4):349-356
International Journal of Clinical and Laboratory Research - The aim of the present investigation was to study the effects of a single 100-µg i.v. administration of the synthetic... 相似文献