全文获取类型
收费全文 | 11906篇 |
免费 | 1175篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 176篇 |
儿科学 | 459篇 |
妇产科学 | 221篇 |
基础医学 | 1496篇 |
口腔科学 | 133篇 |
临床医学 | 1522篇 |
内科学 | 2704篇 |
皮肤病学 | 125篇 |
神经病学 | 1108篇 |
特种医学 | 574篇 |
外科学 | 1943篇 |
综合类 | 151篇 |
一般理论 | 4篇 |
预防医学 | 856篇 |
眼科学 | 398篇 |
药学 | 607篇 |
1篇 | |
中国医学 | 7篇 |
肿瘤学 | 642篇 |
出版年
2023年 | 107篇 |
2022年 | 69篇 |
2021年 | 364篇 |
2020年 | 231篇 |
2019年 | 359篇 |
2018年 | 439篇 |
2017年 | 322篇 |
2016年 | 349篇 |
2015年 | 386篇 |
2014年 | 494篇 |
2013年 | 623篇 |
2012年 | 932篇 |
2011年 | 906篇 |
2010年 | 498篇 |
2009年 | 463篇 |
2008年 | 699篇 |
2007年 | 616篇 |
2006年 | 578篇 |
2005年 | 571篇 |
2004年 | 505篇 |
2003年 | 416篇 |
2002年 | 378篇 |
2001年 | 122篇 |
2000年 | 95篇 |
1999年 | 89篇 |
1998年 | 135篇 |
1997年 | 127篇 |
1996年 | 117篇 |
1995年 | 91篇 |
1994年 | 83篇 |
1993年 | 77篇 |
1992年 | 97篇 |
1991年 | 77篇 |
1990年 | 77篇 |
1989年 | 89篇 |
1988年 | 96篇 |
1987年 | 126篇 |
1986年 | 97篇 |
1985年 | 99篇 |
1984年 | 86篇 |
1983年 | 78篇 |
1982年 | 75篇 |
1981年 | 64篇 |
1980年 | 43篇 |
1979年 | 58篇 |
1978年 | 50篇 |
1976年 | 48篇 |
1974年 | 47篇 |
1973年 | 41篇 |
1972年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Toshiro Hara Rony Chanoch-Myers Nathan D. Mathewson Chad Myskiw Lyla Atta Lillian Bussema Stephen W. Eichhorn Alissa C. Greenwald Gabriela S. Kinker Christopher Rodman L. Nicolas Gonzalez Castro Hiroaki Wakimoto Orit Rozenblatt-Rosen Xiaowei Zhuang Jean Fan Tony Hunter Inder M. Verma Kai W. Wucherpfennig Itay Tirosh 《Cancer cell》2021,39(6):779-792.e11
2.
Many patients with terminal cancer wish to die at home and general practitioners in the United Kingdom have a critical role in providing this care. However, it has been suggested general practitioners lack confidence in end-of-life care. It is important to explore with general practitioners their experience and perspectives including feelings of confidence delivering end-of-life care to people with cancer. The aim of this study was to explore general practitioners experiences of providing end-of-life care for people with cancer in the home setting and their perceptions of confidence in this role as well as understanding implications this has on policy design. A qualitative study design was employed using semi-structured interviews and analysed using thematic analysis. Nineteen general practitioners from London were purposively sampled from eight general practices and a primary care university department in 2018–2019, supplemented with snowballing methods. Five main themes were constructed: (a) the subjective nature of defining palliative and end-of-life care; (b) importance of communication and managing expectations; (c) complexity in prescribing; (d) challenging nature of delivering end-of-life care; (e) the unclear role of primary care in palliative care. General practitioners viewed end-of-life care as challenging; specific difficulties surrounded communication and prescribing. These challenges coupled with a poorly defined role created a spread in perceived confidence. Experience and exposure were seen as enabling confidence. Specialist palliative care service expansion had important implications on deskilling of essential competencies and reducing confidence levels in general practitioners. This feeds into a complex cycle of causation, leading to further delegation of care. 相似文献
3.
Md Maksudul Alam Janmaris Marin Fermin Patrick T. Spiller Chaning Burnett Xiaohua Rong Tara Moore-Medlin Caden O. Maxwell Alok R. Khandelwal Cherie-Ann O. Nathan 《Molecular carcinogenesis》2022,61(1):33-44
TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts. Rapalogs significantly reduced cell viability and colony formation. Interestingly, rapalogs-induced autophagy with no effect on apoptosis. Pretreatment with autophagy inhibitors, 3-methyladenine (3-MA) and ULK-101 rescued the cell viability by inhibiting rapalog-induced autophagy, suggesting that both RAD001 and CCI-779 induce non-apoptotic autophagy-dependent cell death (ADCD). Moreover, rapalogs upregulated the levels of ULK1 and pULK1 S555 with concomitant downregulation of the mTORC1 pathway. However, pretreatment of cells with rapalogs prevented the ULK-101-mediated inhibition of ULK1 to sustained autophagy, suggesting that rapalogs induce ADCD through the activation of ULK1. To further translate our in vitro studies, we investigated the effect of RAD001 in HPV-negative mutTP53 (HN31 and FaDu) tumor cell xenograft model in nude mice. Mice treated with RAD001 exhibited a significant tumor volume reduction without induction of apoptosis, and with a concomitant increase in autophagy. Further, treatment with RAD001 was associated with a considerable increase in pULK1 S555 and ULK1 levels through the inhibition of mTORC1. 3-MA reversed the effect of RAD001 on FaDu tumor growth suggesting that RAD001 promotes ACDC in HPV-negative mutTP53 xenograft. This is the first report demonstrating that rapalogs promote non-apoptotic ADCD in HPV-negative mutTP53 HNSCC via the ULK1 pathway. Further studies are required to establish the promising role of rapalogs in preventing the regrowth of HPV-negative mutTP53 HNSCC. 相似文献
4.
John T. Langfitt Mark Quigg Guofen Yan Wei Yu Mariann M. Ward Nicholas M. Barbaro Edward F. Chang Donna K. Broshek Kenneth D. Laxer Andrew J. Cole Penny K. Sneed Christopher Hess Manjari Tripathi Christiaanne N. Heck John W. Miller Paul A. Garcia Andrew McEvoy Nathan B. Fountain Vicenta Salanova Robert C. Knowlton Anto Bagi Thomas Henry Siddharth Kapoor Guy McKhann Adriana E. Palade Markus Reuber Evelyn Tecoma 《Epilepsia》2019,60(7):1453-1461
5.
Nathan L. Haas Adam Nicholson Mary R.C. Haas 《The American journal of emergency medicine》2019,37(10):1990.e3-1990.e5
Delusional parasitosis manifests as a fixed, false belief that an individual is infested by living organisms. Primary delusional parasitosis is a psychiatric disorder with the delusion as an isolated manifestation, whereas secondary delusional parasitosis is a delusion occurring secondary to a psychiatric disorder, substance use, or medical illness. A 62-year-old woman with no psychiatric history presented to the Emergency Department with two to three months of “whole body itching” and seeing small insects crawling on her skin and in her hair. Exam of her skin and scalp was notable for no appreciable lesions, rashes, excoriations, or insects. Her neurologic exam was notable for full visual fields, and no localizing deficits. A non-contrast head CT demonstrated a nonspecific heterogeneous low-attenuation lesion within the medial right occipital lobe, and a follow up MRI confirmed a right posterior cerebral artery distribution subacute infarction. She was admitted for two days, and ultimately was discharged on aspirin and atorvastatin for secondary prevention. An emergency physician should remain vigilant in his/her assessment of patients with seemingly psychiatric symptoms, in particular elderly patients with no known psychiatric illnesses. Neuroimaging should be amongst studies considered in the evaluation of elderly patients presenting with new onset psychiatric complaints. 相似文献
6.
7.
8.
Aditya Bansal Faisal Akhtar Nathan P Zwintscher Sheila Ostrow Sapna Desai David Fary 《Journal of cardiac surgery》2019,34(12):1629-1631
Right ventricular failure continues to be the Achilles heel in the management of heart failure patients. Traditionally, either high doses of inotropes and inhaled nitric oxide or jerry‐rigged temporary mechanical devices have been used to support failing right ventricles. No durable implantable right ventricular assist device has been developed to address this long‐standing concern. Because of this vacuum of innovation, surgeons have started using the third‐generation LVADs to support the right ventricle. The HeartMate 3 (Abbott) LVAD is a safe and effective therapy for the management of biventricular failure. 相似文献
9.
10.
Susan Heavey Helena Costa Hayley Pye Emma C. Burt Sophia Jenkinson Georgina-Rose Lewis Leticia Bosshard-Carter Fran Watson Charles Jameson Marzena Ratynska Imen Ben-Salha Aiman Haider Edward W. Johnston Andrew Feber Greg Shaw Ashwin Sridhar Senthil Nathan Prabhakar Rajan Timothy P. Briggs Prasanna Sooriakumaran John D. Kelly Alex Freeman Hayley C. Whitaker 《The Prostate》2019,79(7):768-777