氯沙坦对原发性高血压患者尿酸的影响

目的　探讨氯沙坦对原发性高血压患者尿酸的影响。方法　原发性高血压 31例在常规钙拮抗剂治疗 1周后 ,随机分治疗组加用氯沙坦 ,对照组不加用 ,比较两组血清尿酸 ,尿尿酸测值。结果　治疗组血清尿酸水平降低。结论　氯沙坦能降低血清尿酸水平 ,增加泌尿系尿酸排泄     

运动损伤所致骨化性肌炎临床与病理分析

目的：探讨运动损伤所致骨化性肌炎的临床和病理特征。方法分析12例骨化性肌炎患者的临床和病理学资料。结果12例患者均有外伤史。其中,下肢软组织6例,上肢和腰背部各2例,臀部和颈部各1例。光镜下显示特征性的区带结构,为位于中央的纤维细胞和周边的骨组织增生;免疫组化染色显示细胞阳性表达平滑肌肌动蛋白、肌动蛋白、波形蛋白。结论骨化性肌炎是局限性、自限性的修复性病变,好发于四肢软组织;早期病变应注意与骨外骨肉瘤、指趾纤维骨性假瘤、骨纤维结构不良等鉴别。     

HPLC测定硫酸氢氯吡格雷阿司匹林片有关物质

目的 建立HPLC法测定硫酸氢氯吡格雷阿司匹林片有关物质。方法 采用Waters XBridge Shield RP18色谱柱（250×4.6 mm, 5 μm）,以0.1%三乙胺溶液（用磷酸调节pH值至2.5±0.1）-甲醇为流动相进行梯度洗脱,流速为1.0 mL?min ?1,检测波长为 220 nm。 结果 各杂质与主峰之间的分离度良好,阿司匹林杂质C、D、E、F、及氯吡格雷杂质A浓度分别在0.59～178.32 μg/ml、0.31～12.47 μg/ml、0.33～13.21 μg/ml、0.31～18.49 μg/ml和0.76～30.28 μg/ml内与峰面积呈良好的线性关系,r 分别为0.9999、1.0000、0.9998、0.9997和0.9999。阿司匹林杂质C、D、E、F、及氯吡格雷杂质A 加样回收率的平均值分别为97.47%、102.16%、102.20%、103.71%和104.16%,RSD分别为5.35%、1.93%、1.40%、4.63%和2.45%。结论 本方法简便、准确可靠,适用于硫酸氢氯吡格雷阿司匹林片中有关物质的控制。     

梅毒血清固定患者血清IL-10和IL-12水平及相关性分析

目的:通过检测正常人群、梅毒未治疗患者、梅毒治疗后非梅毒螺旋体抗原血清试验转阴患者和梅毒血清固定患者血清IL-10、IL-12水平,并对梅毒血清固定患者血清IL-10和IL-12作相关性分析。以探讨细胞免疫与梅毒血清固定的关系,为有效治疗梅毒血清固定患者提供一定的理论依据。方法:采用双抗体夹心ELISA法分别检测正常人群组、梅毒未治疗组、梅毒治疗转阴组和梅毒血清固定组的IL-10和IL-12水平,将各组IL-10和IL-12水平行统计学分析。对梅毒血清固定组中IL-10与IL-12作相关性分析。结果:梅毒血清固定组患者IL-10水平显著高于正常对照组(P<0.01)、治疗后阴转组(P<0.01)及梅毒未治疗组(P<0.05);梅毒血清固定组患者IL-12水平与正常对照组、治疗后阴转组及梅毒未治疗组之间差异无显著性(P>0.05);梅毒血清固定组患者IL-10与IL-12水平之间无明显相关性(r=0.417,P>0.05)。结论:梅毒血清固定组患者机体内细胞免疫受到一定程度的抑制,发生了免疫不平衡,这种免疫抑制和不平衡可能造成了梅毒螺旋体能够逃脱机体的免疫监视而残存,成为引起血清固定的原因之一。     

Ultrasensitive detection of low-ppm H2S gases based on palladium-doped porous silicon sensors

In this study, the sensing properties of palladium-doped porous silicon (Pd/p-Si) substrates for low-ppm level detection of toxic H₂S gas are investigated. A Si substrate with dead-end pores ranging from nano- to macroscale was generated by a combined process of metal-assisted chemical etching (MacE) and electrochemical etching with tuned reaction time, in which nano-Pd catalysts were decorated by E-beam sputtering deposition. The sensing properties of the Pd/p-Si were enhanced as the thickness of the substrate layer increased; along with the resulting variation in surface area, this resulted in superior H₂S sensing performances in the low-ppm range (less than 3 ppm), with a detection limit of 300 ppb (sensitivity 30%) at room temperature. Furthermore, the sensor displayed excellent selectivity toward the hazardous H₂S molecules in comparison with various other reducing gases, including NO₂, CO₂, NH₃, and H₂, showing its potential for application in workplaces or environments affected by other toxic gases. The enhancement in sensing performance was possibly due to the increased dispersion and surface area of Pd nano-catalysts, which led to an increase in chemisorption sites of adsorbate molecules.

In this study, the sensing properties of palladium-doped porous silicon (Pd/p-Si) substrates for low-ppm level detection of toxic H₂S gas are investigated.     

'Moffett's' solution: a review of the evidence and scientific basis for the topical preparation of the nose

General anaesthesia, often causes a widespread vasodilation, producing a hyperaemic nasal mucosa, hence the need for a topical application to decongest the nose and reduce the nasal blood flow to optimize the operative field. The use of a combination of cocaine, sodium bicarbonate and adrenaline given the eponymous title of 'Moffett's Solution' is standard practice in many rhinological procedures to provide local anaesthesia, vasoconstriction and decongestion. We discuss each component of 'Moffett's' reviewing the science and evidence behind its usage and the huge variation in the techniques of its application.     

Functional assessment of the paediatric laryngeal airway

After resolution of conditions necessitating tracheostomy in children, decannulation may be extremely difficult and associated with significant morbidity. Endoscopy and radiography can identify anatomical abnormalities preventing decannulation. Physiological abnormalities are, however, more difficult to assess. A system has been developed whereby functional upper airway resistance can be calculated in children with a tracheostomy. The instrument used was a modified Mercury Electronics rhinomanometer. A probe was placed through the tracheostome and another probe was situated in an occluding anaesthetic face mask. Upper airway resistance was derived from the differential pressure and flow changes recorded in anaesthetized children who were breathing spontaneously. Studies in 26 children have revealed low airway resistance in all those successfully decannulated. Further studies will hopefully allow identification in advance of children who will have decannulation difficulties.