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排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
de Souza Evanice Avelino Alves Felipe Rocha Façanha Josana Nunes Torres Michele Gonçalves Romcy 《Sport Sciences for Health》2022,18(2):473-480
Sport Sciences for Health - The practice of physical activity has been recommended during the pandemic period of COVID-19 as a way of preventing the worsening of physical and mental health. After... 相似文献
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Buket Bakan Fatih Oltulu Yeliz Y?ld?r?m Altu? Yava?o?lu Sinan Akg?l Nefise ülkü Karabay Yava?o?lu 《Arhiv za higijenu rada i toksikologiju》2023,74(3):207
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.KEY WORDS: biocompatibility, blood biochemistry, genotoxicity, histology, in vivo toxicity, micronucleus test, polymers 相似文献
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Cappellari Manuel Sajeva Giulia Augelli Raffaele Zivelonghi Cecilia Plebani Mauro Mandruzzato Nicolò Mangiafico Salvatore 《Journal of thrombosis and thrombolysis》2022,54(3):550-557
Journal of Thrombosis and Thrombolysis - The ability of the current grading systems to predict optimal outcomes in stroke patients with favourable collaterals remains unexplored. We evaluated... 相似文献
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Penelas Alice Gonçalves da Silva Eduardo Moreira Fedozzi Julia Mattos Alves Amanda Cypriano Orem Paulo Roberto Barros Poskus Laiza Tatiana Feitosa Victor Pinheiro Guimarães José Guilherme Antunes 《Odontology / the Society of the Nippon Dental University》2022,110(3):569-576
Odontology - This study aimed at evaluating the influence of glass-fiber post (GFP) relining with composites of different opacities on resin cement layer thickness (CLT), bond strength (BS) to root... 相似文献
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Fett Mauro Sander Mariot Roberta Fogliatto Avila Eduardo Alho Clarice Sampaio Stefenon Valdir Marcos de Oliveira Camargo Flávio Anastácio 《International journal of legal medicine》2019,133(2):373-384
International Journal of Legal Medicine - It is known that Cannabis in Brazil could either originate from Paraguay or be cultivated in Brazil. While consumer markets in the North and Northeast... 相似文献
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Oliveira Gonalves Ana Sofia Panteli Dimitra Neeb Lars Kurth Tobias Aigner Annette 《The European journal of health economics》2022,23(1):47-57
The European Journal of Health Economics - The aims of this study were to assess whether there is a conceptual overlap between the questionnaires HIT-6 and EQ-5D and to develop a mapping algorithm... 相似文献