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MP29‐02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite‐allergic rhinitis 下载免费PDF全文
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Alexander Gröbe Henning Hanken Ahmed Al-Dam Georg Cachovan Ralf Smeets Antje Krohn Till Clauditz Tobias Grob Ronald Simon Guido Sauter Lan Kluwe Max Heiland Marco Blessmann 《Clinical oral investigations》2014,18(1):211-217
Objectives
The present study aims to investigate the relevance of immunohistochemical p53 expression in carcinomas of the oral cavity and of the head and neck region. Long-term clinical and histopathological follow-up findings as well as HPV status are correlated with the results of this examination.Materials and methods
Sections made from two tissue arrays composed of 222 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, were examined for p53 expression and Ki-67 index by means of immunohistochemistry. Correlation of long-term clinical findings of the patients and pathological features of tumours with laboratory results were examined statistically.Results
No significant correlation was found between the p53 immunohistochemical expression in the 207 oral carcinomas and features of the tumours and patient outcomes. There was no significant association between the Ki-67 labelling index and the p53 expression.Discussion
Our failure in detecting any association of the p53 immunohistochemical expression regardless of HPV status with clinical features of these tumours suggests it lacks a prognostic value for squamous cell carcinomas of the oral cavity.Clinical relevance
The prognostic value of p53 immunostaining in oral squamous carcinoma is not clarified yet. In the present study, there is no impact on any prognostical item nor even a correlation with cell proliferation (Ki-67) regardless of HPV status. 相似文献5.
The therapeutic results of operatively and conservatively treated patients with lumbar disc syndromes were reviewed in a retrospective study. The patients were treated during a 10-years period (1976-1985). A total of 330 patients with lumbar disc prolapses were treated in the hospital during this period 44% were treated surgically. The data on 100 operated and 100 conservatively treated cases, registered in this random test sample, have been compared with respect to: pain; neurological deficits; subjective problems and sociomedical questions. The average patient age of both groups was about 41 years, and the patients predominant were male (about 70%). The therapeutic results of both operatively and conservatively treated patients were good, which is also by the high percentage of employment (80%-90%) in the two treatment groups. The critical evaluation showed more neurological disturbances and limited vocational activity in the group of cases operated upon. More than 70% of the operated cases showed radicular syndromes of the follow-up examination although it was not of essential functional importance. The period inability to work and the percentage of disablement were also much higher in this group. The pain symptoms were particularly relevant in our examination. Only 12%-16% of the patients in the two groups that took part in the follow-up examinations reported freedom from pain. It was apparent that atypical pain syndromes were correlated with personality psychological disturbances. Nearly one-third of our patients mentioned psychological problems. The prognosis of the conservative treatment of lumbar disc prolapse was equivalent to operative therapy (disregarding the absolute indications for operations). There were no definite advantages found for either of the two methods of treatment. The necessity for a specialized follow-up treatment of patients with sciatica due to herniated lumbar discs is discussed, and differentiated selection for operative therapy is given. Here the treatment of pain should be considered most important. 相似文献
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Marcel K?hn Christian Ihling Andrea Sinz Knut Krohn Stefan Hüttelmaier 《Genes & development》2015,29(19):1998-2003
We demonstrate that the Y3/Y3** noncoding RNAs (ncRNAs) bind to the CPSF (cleavage and polyadenylation specificity factor) and that Y3** associates with the 3′ untranslated region (UTR) of histone pre-mRNAs. The depletion of Y3** impairs the 3′ end processing of histone pre-mRNAs as well as the formation and protein dynamics of histone locus bodies (HLBs), the site of histone mRNA synthesis and processing. HLB morphology is also disturbed by knockdown of the CPSF but not the U7-snRNP components. In conclusion, we propose that the Y3** ncRNA promotes the 3′ end processing of histone pre-mRNAs by enhancing the recruitment of the CPSF to histone pre-mRNAs at HLBs. 相似文献
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The role of HPV RNA transcription,immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer 下载免费PDF全文
Knut Krohn Markus Kreuz Andreas Boehm Anett Reiche Ulrike Scharrer Dirk Halama Julia Bertolini Ulrike Bauer Dana Holzinger Michael Pawlita Jochen Hess Christoph Engel Dirk Hasenclever Markus Scholz Peter Ahnert Holger Kirsten Alexander Hemprich Christian Wittekind Olf Herbarth Friedemann Horn for the Leipzig Head Neck Group 《International journal of cancer. Journal international du cancer》2015,137(12):2846-2857
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