全文获取类型
收费全文 | 577篇 |
免费 | 61篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 14篇 |
妇产科学 | 16篇 |
基础医学 | 77篇 |
口腔科学 | 4篇 |
临床医学 | 87篇 |
内科学 | 124篇 |
皮肤病学 | 21篇 |
神经病学 | 63篇 |
特种医学 | 15篇 |
外科学 | 75篇 |
综合类 | 2篇 |
预防医学 | 48篇 |
眼科学 | 21篇 |
药学 | 41篇 |
中国医学 | 1篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 11篇 |
2022年 | 11篇 |
2021年 | 36篇 |
2020年 | 34篇 |
2019年 | 43篇 |
2018年 | 45篇 |
2017年 | 28篇 |
2016年 | 28篇 |
2015年 | 17篇 |
2014年 | 34篇 |
2013年 | 38篇 |
2012年 | 42篇 |
2011年 | 51篇 |
2010年 | 27篇 |
2009年 | 19篇 |
2008年 | 37篇 |
2007年 | 28篇 |
2006年 | 28篇 |
2005年 | 27篇 |
2004年 | 15篇 |
2003年 | 12篇 |
2002年 | 16篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1986年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有641条查询结果,搜索用时 31 毫秒
1.
de Farias Jade Ormondes de Freitas Lima Stella Maris Rezende Taia Maria Berto 《Clinical oral investigations》2020,24(12):4197-4212
Clinical Oral Investigations - A narrative review on the NO properties and their relationship with the oral environment describing NO’s molecular origin, role, and perspectives regarding oral... 相似文献
2.
Srivastava Ankur Winn Jade Senese John Goldbach Jeremy T. 《Archives of sexual behavior》2022,51(7):3361-3376
Archives of Sexual Behavior - This article reviews research on changes in self-reported sexual orientation labels and associated health outcomes among adolescents and young adults. Using seven... 相似文献
3.
4.
Isabel De Bruin Cardoso Lopa Bhattacharjee Claire Cody Joanna Wakia Jade Tachie Menson Maricruz Tabbia 《Vulnerable children and youth studies》2020,15(2):114-123
ABSTRACT Between 2015 and 2018, the RISE Learning Network facilitated learning on approaches, practices, methods, and tools that promote recovery and reintegration of children affected by sexual exploitation. Spanning three regions (Sub-Saharan Africa, South Central Asia, and Latin America and the Caribbean), the RISE Learning Network implemented two learning projects. The first project focused on monitoring (M&E Learning Project) and aimed to generate understanding of approaches and tools that could effectively monitor children and families’ reintegration outcomes. The specific purpose of RISE is to promote learning on reintegration of children affected by sexual exploitation; however, the remit of this Learning Project was to generate evidence on the reintegration of children who have been separated from their families for a range of reasons. This is to ensure that learning from different, but often related, areas of work can be included and compared to strengthen understanding of what successful reintegration of children could look like. The mid- and end-term reviews of the M&E Learning Project have captured lessons learned on how practitioners can approach monitoring of reintegration to mainstream it into their programme cycle. Key lessons learned include the importance of focusing on monitoring outcomes through participatory tools and the benefit of flexible, peer-to-peer learning approaches between practitioners using a variety of monitoring tools. This learning contributes to the nascent evidence base on what effective and efficient capturing of reintegration outcomes on children can look like, in addition to strengthening understanding of what successful reintegration for children and families means. The learnings can inform programming; monitoring, evaluation and learning frameworks; and other interventions around reintegration to ensure the holistic wellbeing of children and families. 相似文献
5.
Anke de Haan Markus A. Landolt Eiko I. Fried Kristian Kleinke Eva Alisic Richard Bryant Karen Salmon Sue-Huei Chen Shu-Tsen Liu Tim Dalgleish Anna McKinnon Alice Alberici Jade Claxton Julia Diehle Ramón Lindauer Carlijn de Roos Sarah L. Halligan Rachel Hiller Christian H. Kristensen Beatriz O.M. Lobo Nicole M. Volkmann Meghan Marsac Lamia Barakat Nancy Kassam-Adams Reginald D.V. Nixon Susan Hogan Raija-Leena Punamäki Esa Palosaari Elizabeth Schilpzand Rowena Conroy Patrick Smith William Yule Richard Meiser-Stedman 《Journal of child psychology and psychiatry, and allied disciplines》2020,61(1):77-87
6.
Preetanshu Pandey Christopher Levins Steve Pafiakis Brian Zacour Dilbir S. Bindra Jade Trinh 《Pharmaceutical development and technology》2018,23(6):587-595
AbstractThe objective of this study was to improve the disintegration and dissolution characteristics of a highly water-soluble tablet matrix by altering the manufacturing process. A high disintegration time along with high dependence of the disintegration time on tablet hardness was observed for a high drug loading (70% w/w) API when formulated using a high-shear wet granulation (HSWG) process. Keeping the formulation composition mostly constant, a fluid-bed granulation (FBG) process was explored as an alternate granulation method using a 2(4?1) fractional factorial design with two center points. FBG batches (10 batches) were manufactured using varying disingtegrant amount, spray rate, inlet temperature (T) and atomization air pressure. The resultant final blend particle size was affected significantly by spray rate (p?=?.0009), inlet T (p?=?.0062), atomization air pressure (p?=?.0134) and the interaction effect between inlet T*spray rate (p?=?.0241). The compactibility of the final blend was affected significantly by disintegrant amount (p?<?.0001), atomization air pressure (p?=?.0013) and spray rate (p?=?.05). It was observed that the fluid-bed batches gave significantly lower disintegration times than the HSWG batches, and mercury intrusion porosimetry data revealed that this was caused by the higher internal pore structure of tablets manufactured using the FBG batches. 相似文献
7.
8.
9.
Sowjanya Kallakuri Jianxin A. Yu Jade Li Yuanyuan Li Brant M. Weinstein Stefania Nicoli Zhaoxia Sun 《Journal of the American Society of Nephrology : JASN》2015,26(4):864-875
The cilium is a signaling platform of the vertebrate cell. It has a critical role in polycystic kidney disease and nephronophthisis. Cilia have been detected on endothelial cells, but the function of these organelles in the vasculature remains incompletely defined. In this study, using genetic and chemical genetic tools in the model organism zebrafish, we reveal an essential role of cilia in developmental vascular integrity. Embryos expressing mutant intraflagellar transport genes, which are essential and specific for cilia biogenesis, displayed increased risk of developmental intracranial hemorrhage, whereas the morphology of the vasculature remained normal. Moreover, cilia were present on endothelial cells in the developing zebrafish vasculature. We further show that the involvement of cilia in vascular integrity is endothelial autonomous, because endothelial-specific re-expression of intraflagellar transport genes in respective mutants rescued the intracranial hemorrhage phenotype. Finally, whereas inhibition of Hedgehog signaling increased the risk of intracranial hemorrhage in ciliary mutants, activation of the pathway rescued this phenotype. In contrast, embryos expressing an inactivating mutation in pkd2, one of two autosomal dominant cystic kidney disease genes, did not show increased risk of developmental intracranial hemorrhage. These results suggest that Hedgehog signaling is a major mechanism for this novel role of endothelial cilia in establishing vascular integrity. 相似文献
10.
Severien Van Keer Wiebren A. A. Tjalma Jade Pattyn Samantha Biesmans Zoë Pieters Xaveer Van Ostade Margareta Ieven Pierre Van Damme Alex Vorsters 《European journal of clinical microbiology & infectious diseases》2018,37(5):859-869
The performance and acceptability of first-void urine as specimen for the detection of HPV DNA in a Belgian referral population was evaluated using an optimized sample collection and processing protocol. One hundred ten first-void urine and cervical samples were collected from 25- to 64-year-old women who were referred for colposcopy (January–November 2016). Paired samples were analyzed by the Riatol qPCR HPV genotyping assay. Acceptability data were gathered through questionnaires (NCT02714127). A higher high-risk HPV DNA prevalence was observed in first-void urine (n?=?76/110) compared to cervical samples (n?=?73/110), with HPV31 and HPV16/31 being most prevalent correspondingly. For both any and high-risk HPV DNA, good agreement was observed between paired samples (Cohen’s Kappa of 0.660 (95% CI: 0.486–0.833) and 0.688 (95% CI: 0.542–0.835), respectively). In addition, significant positive correlations in HPV copies (per microliter of DNA extract) between paired samples were observed for HPV16 (rs?=?0.670; FDR (false discovery rate)-adjusted p?=?0.006), HPV18 (rs?=?0.893; FDR-adjusted p?=?0.031), HPV31 (rs?=?0.527; FDR-adjusted p?=?0.031), HPV53 (rs?=?0.691; FDR-adjusted p?=?0.017), and HPV68 (rs?=?0.569; FDR-adjusted p?=?0.031). First-void urine sampling using a first-void urine collection device was preferred over a clinician-collected cervical sample. And mostly, first-void urine sampling at home was favored over collection at the clinic or the general practitioner’s office. First-void urine sampling is a highly preferred, non-invasive method that ensures good agreement in HPV DNA (copies) with reference cervical samples. It is particularly interesting as a screening technique to reach non-participants, and its clinical performance should be further evaluated. 相似文献