全文获取类型
收费全文 | 1923篇 |
免费 | 174篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 30篇 |
妇产科学 | 24篇 |
基础医学 | 324篇 |
口腔科学 | 22篇 |
临床医学 | 211篇 |
内科学 | 440篇 |
皮肤病学 | 61篇 |
神经病学 | 80篇 |
特种医学 | 82篇 |
外科学 | 236篇 |
综合类 | 20篇 |
一般理论 | 1篇 |
预防医学 | 192篇 |
眼科学 | 80篇 |
药学 | 171篇 |
中国医学 | 6篇 |
肿瘤学 | 127篇 |
出版年
2023年 | 18篇 |
2022年 | 19篇 |
2021年 | 109篇 |
2020年 | 51篇 |
2019年 | 86篇 |
2018年 | 80篇 |
2017年 | 41篇 |
2016年 | 60篇 |
2015年 | 63篇 |
2014年 | 98篇 |
2013年 | 101篇 |
2012年 | 152篇 |
2011年 | 133篇 |
2010年 | 68篇 |
2009年 | 68篇 |
2008年 | 110篇 |
2007年 | 113篇 |
2006年 | 94篇 |
2005年 | 89篇 |
2004年 | 86篇 |
2003年 | 74篇 |
2002年 | 60篇 |
2001年 | 46篇 |
2000年 | 38篇 |
1999年 | 32篇 |
1998年 | 12篇 |
1997年 | 11篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 17篇 |
1990年 | 16篇 |
1989年 | 12篇 |
1988年 | 22篇 |
1987年 | 13篇 |
1986年 | 10篇 |
1985年 | 17篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1968年 | 4篇 |
1964年 | 1篇 |
排序方式: 共有2118条查询结果,搜索用时 15 毫秒
1.
Quang Ngoc Nguyen Linh Dieu Vuong Van-Long Truong To Van Ta Nam Trung Nguyen Hung Phi Nguyen Ha Hoang Chu 《Pathology, research and practice》2019,215(5):885-892
Genetic and epigenetic alterations importantly contribute to the pathogenesis of lung cancer. In the study, we measured the frequency and distribution of molecular abnormalities of EGFR as well as the aberrant promoter methylations of BRCA1, MGMT, MLH1, and RASSF1A in Vietnamese lung adenocarcinomas. We investigated the association between genetic and epigenetic alteration, and between each abnormality with clinicopathologic parameters. Somatic EGFR mutation that was found in 49/139 (35.3%) lung adenocarcinomas showed a significant association with young age, female gender, and non-smokers. EGFR overexpression was identified in 82 tumors (59.0%) and statistical relationships with EGFR or BRCA1 methylation but not EGFR mutation. In addition, EGFR, BRCA1, MGMT, MLH1, and RASSF1A methylations were found in 33 (23.7%), 41 (29.5%), 46 (33.1%), 28 (20.1%), and 41 (29.5%) cases of a total of 139 lung adenocarcinomas, respectively. The RASSF1A methylation was found to be linked to the smoking habit. Methylations in MGMT and RASSF1A were also found to correlate with metastasis status. Furthermore, the distribution of EGFR mutation and that of BRCA1, MGMT or RASSF1A methylation were significantly exclusive in lung adenocarcinomas. The main finding of our study demonstrate that epigenetic abnormalities might play a critical role for the lung tumorigenesis in patients with smoking history and metastasis, and partly affect the predictive value of EGFR mutations through blocking expression due to promoter EGFR hypermethylation. Mutually exclusive distribution of genetic and epigenetic alterations reflects differently biological characteristics in the etiology of lung adenocarcinomas. 相似文献
2.
Dougherty Ryan J. Hoang Tina D. Launer Lenore J. Jacobs David R. Sidney Stephen Yaffe Kristine 《Brain imaging and behavior》2022,16(2):637-644
Brain Imaging and Behavior - The purpose of this study was to investigate whether long-term television viewing patterns, a common sedentary behavior, in early to mid-adulthood is associated with... 相似文献
3.
Recurrent BRCA1 Mutation,but no BRCA2 Mutation,in Vietnamese Patients with Ovarian Carcinoma Detected with Next Generation Sequencing 下载免费PDF全文
Hoang Anh VuNgo Dai PhuLe Thai KhuongPham Huy HoaBui Thi Hong NhuVo Thanh NhanLe Quang ThanhNguyen Duy SinhHoang Thanh ChiNguyen Dang QuanNguyen Trong Binh 《Asian Pacific journal of cancer prevention》2020,21(8):2331-2335
Background: Identification of germline and somatic BRCA1/2 mutations in ovarian cancer is important for genetic counseling and treatment decision making with poly ADP ribose polymerase inhibitors. Unfortunately, data on the frequency of BRCA1/2 mutations in Vietnamese patients are scare. Methods: We aim to explore the occurrence of BRCA1/2 mutations in 101 Vietnamese patients with ovarian cancer including serous (n = 58), endometrioid (n = 14), mucinous (n = 24), and clear cell (n = 5) carcinomas. BRCA1/2 mutations were detected from formalin-fixed parafin-embedded tumor samples using the OncomineTM BRCA Research Assay on Personal Genome Machine Platform with Ion Reporter Software for sequencing data analysis. The presence of pathogenic mutations was confirmed by Sanger sequencing. Results: We found no BRCA2 mutation in the entire cohort. Four types of pathogenic mutations in BRCA1 (Ser454Ter, Gln541Ter, Arg1751Ter, and Gln1779AsnfsTer14) were detected in 8 unrelated patients (7.9%) belonging to serous and endometrioid carcinoma groups. Except for the c.1360_1361delAG (Ser454Ter) mutation in BRCA1 exon 11 that was somatic, the other mutations in exons 11, 20, and 22 were germline. Interestingly, the recurrent Arg1751Ter mutation in BRCA1 exon 20 appeared in 4 patients, suggesting that this is a founder mutation in Vietnamese patients. Conclusion: Mutational analysis of tumor tissue using next generation sequencing allowed the detection of both germline and somatic BRCA1/2 mutations. 相似文献
4.
5.
Raphaëlle Jouin Denis Chateaux Dominique Drapier Thierry Pham Hoang 《Annales médico-psychologiques》2019,177(9):902-910
Klinefelter syndrome (KS) (47,XXY) is the most common aneuploidy (1/650) of sexual chromosome among male (0,1 à 0,2 % of male population) (Hong and Reiss, 2014). Because its large physical phenotypic variability (high tall, sparse hairiness, gynecomastia), this syndrome is largely underdiagnosed (less than 25 % of affected persons) (Samango-Sprouse et al., 2018). Nevertheless, cognitive variability is smaller. Normal to low average total IQ, low verbal IQ, social problems and high levels of psychiatric comorbidities including early aggressiveness are commonly described (Hong and Reiss, 2014). In Denmark, higher risks of committing sexual crime and arson (compared to criminal controls) was recently reported (Stochholm et al., 2012). Quite a few clinically relevant cases reports scattered in the literature, suggests the presence of a pattern of a specific subtype of KS inpatients among forensic population (Bénézech, 1975). However, very few studies provide quantitative or qualitative pertaining to robust results. KS well-documented neurobiological (van Rijn, 2018) (e.g. low levels of testosterone), neuropsychological (Bénézech, 1975; Hong and Reiss, 2014; Samango-Sprouse et al., 2018; Savic, 2012; Seara-Cardoso et al., 2016; Senon, 2005; Stochholm et al., 2012; van Rijn, 2018; van Rijn et al., 2008; van Rijn et al., 2018; van Rijn et al., 2014; van Rijn et al., 2012) [29] (e.g. alterations of both complex cerebral — attention, empathy — and behavioral regulation functions - inhibition, mental flexibility, emotional response modulation, control of own actions) and neuroanatomical (Hong and Reiss, 2014; Itti et al., 2003; Savic, 2012; van Rijn et al., 2008; van Rijn et al., 2012) [29] (e.g. limbic system and temporal lobe abnormal volume, hemispheric specialization shortcoming) features may be helpful to understand comorbid symptoms psychopathology. Numbers of recent studies conduct on KS pediatric or adult population provide interesting results on conduct, anxiety, psychotic and autism spectrum disorders. In addition, some authors use genetic and epigenetic specific features of sex chromosome aneuploidies (e.g. X genes neurodevelopmental role; imprinting) in order to clarify genotype-phenotype links of comorbid symptoms (Bruining et al., 2011; Zitzmann et al., 2004;). With Belgian colleagues from the Social Defense Research Center (CRDS, Tournai, Belgium), we are currently recruiting KS inpatients from security hospitals or psychiatric units in Belgium and France. We aim to assess psychopathic traits with the Psychopathy Checklist Revised (PCL-R, Hare) (Hare, 2003). Our first results concerning 3 KS males outline that PCL-R is useful for the characterization of clinical phenotype among KS forensic sample. While three of them present psychopathic traits, two of them present categorical double diagnose “psychopathy-KS” (total PCL-R score > = 30/40 (Delannoy et al., 2017)). Moreover, dimensional analysis support our hypothesis of a higher prevalence of “explosive profile” in comparison to other psychopathic profiles in our sample (Delannoy et al., 2017). The present article summarizes historic background (e.g. “psychopathy” disappearance of mental disorder reference classification schemes, “crime chromosome” (Bénézech, 1975)) and current context argues (e.g. French psychiatrists court experts widely refer to psychopathy concept despite a lack of consensual definition (Senon, 2005), weak knowledge and training of PCL-R and its related biopsychological recent findings (Blair, 2013; de Oliveira-Souza et al., 2008; Dotterer et al., 2017; Glenn and Raine, 2014; Hosking et al., 2017; Korponay et al., 2017; Pham, 1995; Pham, 2005; Raine, 2008; Raine et al., 2003); stigma and discrimination apprehensions of KS and psychopath) that motivate our research project. Finally, we discuss the advantages of our research protocol on KS participants assessed with PCL-R, such as tackling stigma and discrimination, better understanding psychopathology, and clarifying murky interactions of biological, psychological and social factors entangled in the development of these two fascinating troubles. 相似文献
6.
Extensive and Progressing Congenital Dermal Melanocytosis Leading to Diagnosis of GM1 Gangliosidosis 下载免费PDF全文
Priyanka Vedak B.A. Ryan Sells M.D. Aieska De Souza M.D. Ph.D. Mai P. Hoang M.D. Daniela Kroshinsky M.D. M.P.H. 《Pediatric dermatology》2015,32(6):e294-e295
Congenital dermal melanocytosis (CDM) is a birthmark composed of macular blue‐grey hyperpigmentation commonly observed in the lumbosacral region of infants. Generally resolving by childhood, it is traditionally considered a benign condition, but it may be a sign of underlying lysosomal storage disease. We report a case of biopsy‐confirmed CDM in a 2‐month‐old girl of Brazilian descent later diagnosed with infantile GM1 gangliosidosis. 相似文献
7.
Diagnostic value of biparametric magnetic resonance imaging (MRI) as an adjunct to prostate‐specific antigen (PSA)‐based detection of prostate cancer in men without prior biopsies 下载免费PDF全文
Soroush Rais‐Bahrami M. Minhaj Siddiqui Srinivas Vourganti Baris Turkbey Ardeshir R. Rastinehad Lambros Stamatakis Hong Truong Annerleim Walton‐Diaz Anthony N. Hoang Jeffrey W. Nix Maria J. Merino Bradford J. Wood Richard M. Simon Peter L. Choyke Peter A. Pinto 《BJU international》2015,115(3):381-388
8.
Hlne Vallet Pascal Seve Lucie Biard Jean Baptiste Fraison Philip Bielefeld Laurent Perard Boris Bienvenu Sbastien Abad Aude Rigolet Alban Deroux Damien Sene Antoinette Perlat Isabelle Marie Elodie Feurer Eric Hachulla Olivier Fain Gaëlle Clavel Sophie Riviere Pierre‐Alban Bouche Julie Gueudry Gregory Pugnet Phuc Le Hoang Matthieu Resche Rigon Patrice Cacoub Bahram Bodaghi David Saadoun 《Arthritis \u0026amp; Rheumatology》2016,68(6):1522-1530
9.
10.