全文获取类型
收费全文 | 2493篇 |
免费 | 142篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 89篇 |
妇产科学 | 71篇 |
基础医学 | 319篇 |
口腔科学 | 28篇 |
临床医学 | 389篇 |
内科学 | 490篇 |
皮肤病学 | 26篇 |
神经病学 | 192篇 |
特种医学 | 272篇 |
外科学 | 219篇 |
综合类 | 35篇 |
一般理论 | 5篇 |
预防医学 | 221篇 |
眼科学 | 13篇 |
药学 | 158篇 |
中国医学 | 7篇 |
肿瘤学 | 123篇 |
出版年
2023年 | 11篇 |
2021年 | 26篇 |
2020年 | 22篇 |
2019年 | 21篇 |
2018年 | 46篇 |
2017年 | 37篇 |
2016年 | 49篇 |
2015年 | 62篇 |
2014年 | 58篇 |
2013年 | 79篇 |
2012年 | 90篇 |
2011年 | 91篇 |
2010年 | 77篇 |
2009年 | 79篇 |
2008年 | 90篇 |
2007年 | 157篇 |
2006年 | 86篇 |
2005年 | 124篇 |
2004年 | 98篇 |
2003年 | 70篇 |
2002年 | 97篇 |
2001年 | 80篇 |
2000年 | 77篇 |
1999年 | 61篇 |
1998年 | 63篇 |
1997年 | 62篇 |
1996年 | 67篇 |
1995年 | 39篇 |
1994年 | 41篇 |
1993年 | 36篇 |
1992年 | 35篇 |
1991年 | 45篇 |
1990年 | 38篇 |
1989年 | 56篇 |
1988年 | 53篇 |
1987年 | 51篇 |
1986年 | 44篇 |
1985年 | 44篇 |
1984年 | 28篇 |
1983年 | 20篇 |
1982年 | 24篇 |
1981年 | 21篇 |
1980年 | 23篇 |
1979年 | 14篇 |
1978年 | 16篇 |
1977年 | 19篇 |
1976年 | 16篇 |
1975年 | 15篇 |
1971年 | 13篇 |
1970年 | 12篇 |
排序方式: 共有2682条查询结果,搜索用时 46 毫秒
1.
2.
3.
Majke H.D. van Bommel Marieke Arts de Jong Miranda P. Steenbeek Michiel L. Bots Liselore L.M. van Westerop Maria T.E. Hopman Nicoline Hoogerbrugge Joanne A. de Hullu Angela H.E.M. Maas 《Journal of cardiology》2021,77(6):570-575
BackgroundBRCA1/2 mutation carriers are generally exposed to early menopause due to risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 years. This risk-reducing intervention is based on a 10–40% life-time risk of ovarian cancer in this population. Although effective, premature and acute menopause induces non-cancer related morbidity in both the short and long term. Little is known about the impact of RRSO on the cardiovascular system.MethodsThis cross-sectional study explored the relationship between time since RRSO and signs of subclinical atherosclerosis, as measured by carotid intima-media thickness (CIMT) and pulse wave velocity (PWV), in 165 BRCA1/2 mutation carriers. All participants, aged 40 to 63 years, underwent RRSO before the age of 45 years, and at least 5 years ago. Cardiovascular risk factors were assessed by questionnaires and a single screening visit. Data were analyzed using linear regression models.ResultsMean CIMT was 692.7 μm (SD 87.0), and mean central PWV 6.40 m/s (SD 1.42). After adjustment for age and several relevant cardiovascular risk factors, time since RRSO was not associated with CIMT (β=0.68 μm; 95% CI –4.02, 5.38) and PWV (β=44 mm/s; 95% CI –32, 120). Compared to women of a reference group from the general population, lower systolic blood pressure [mean difference 12 mmHg; 95% confidence interval (CI) 10, 14] was found in BRCA1/2 mutation carriers.ConclusionsWe found that, in BRCA1/2 mutation carriers, at 5 to 24 years follow-up, time since RRSO is not related to development of subclinical atherosclerosis. However, the follow-up period in these relatively young women might have been too short. 相似文献
4.
Roderick P.P.W.M. Maas MD Rick C.G. Helmich MD PhD Bart P.C. van de Warrenburg MD PhD 《Movement disorders》2020,35(2):215-227
Over the last three decades, measuring and modulating cerebellar activity and its connectivity with other brain regions has become an emerging research topic in clinical neuroscience. The most important connection is the cerebellothalamocortical pathway, which can be functionally interrogated using a paired-pulse transcranial magnetic stimulation paradigm. Cerebellar brain inhibition reflects the magnitude of suppression of motor cortex excitability after stimulating the contralateral cerebellar hemisphere and therefore represents a neurophysiological marker of the integrity of the efferent cerebellar tract. Observations that cerebellar noninvasive stimulation techniques enhanced performance of certain motor and cognitive tasks in healthy individuals have inspired attempts to modulate cerebellar activity and connectivity in patients with cerebellar diseases in order to achieve clinical benefit. We here comprehensively explore the therapeutic potential of these techniques in two movement disorders characterized by prominent cerebellar involvement, namely the degenerative ataxias and essential tremor. The article aims to illustrate the (patho)physiological insights obtained from these studies and how these translate into clinical practice, where possible by addressing the association with cerebellar brain inhibition. Finally, possible explanations for some discordant interstudy findings, shortcomings in our current understanding, and recommendations for future research will be provided. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. 相似文献
5.
Marit Middeldorp Alies van Lier Nicoline van der Maas Irene Veldhuijzen Wieke Freudenburg Nina M. van Sorge Elisabeth A.M. Sanders Mirjam J. Knol Hester E. de Melker 《Vaccine》2021,39(7):1039-1043
We aimed to assess the impact of the COVID-19 pandemic on the incidence of vaccine-preventable diseases (VPDs) and participation in the routine infant vaccination programme in the Netherlands. The incidence of various VPDs initially decreased by 75–97% after the implementation of the Dutch COVID-19 response measures. The participation in the first measles-mumps-rubella vaccination among children scheduled for vaccination in March-September 2020 initially dropped by 6–14% compared with the previous year. After catch-up vaccination, a difference in MMR1 participation of ?1% to ?2% still remained. Thus, the pandemic has reduced the incidence of several VPDs and has had a limited impact on the routine infant vaccination programme. 相似文献
6.
7.
8.
9.
10.
Nguyen Thoa C Witter Dick J Bronkhorst Ewald M Truong Nhan B Creugers Nico HJ 《BMC oral health》2010,10(1):1-11