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1.
White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure
Della Guardia Lucio Shin Andrew C. 《Journal of molecular medicine (Berlin, Germany)》2022,100(5):665-676
Journal of Molecular Medicine - Chronic exposure to high levels of particulate matter (PM) is correlated to a higher prevalence of cardio-metabolic disturbances. Adipose tissue represents a pivotal... 相似文献
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Won Sohn Yoosoo Chang Yong Kyun Cho Yun Soo Hong Hocheol Shin Seungho Ryu 《Journal of viral hepatitis》2022,29(1):69-77
The predictive role of noninvasive liver fibrosis scores on liver-related mortality in patients with chronic hepatitis B below 40 years of age remains unclarified. We examined the association of liver fibrosis scores with liver-related mortality in young (<40 years) and older adults with hepatitis B virus (HBV) infection. A cohort study was performed in 21,360 HBsAg-positive Korean adults without liver cirrhosis or liver cancer at baseline who were followed up for up to 18 years. The liver fibrosis scores were determined using the fibrosis-4 score (FIB-4) and aspartate transaminase to platelet ratio index (APRI). Patients’ vital status and cause of death were ascertained through the National Death Records. During a median follow-up of 10.2 years, 283 liver-related deaths were identified (liver-related mortality, 127.4/105 person-years). The liver fibrosis scores were significantly associated with increased risks of liver-related mortality; this association did not differ by age group (<40 vs. ≥40 years). The multivariable-adjusted hazard ratios with 95% confidence intervals for liver-related mortality comparing intermediate and high to low FIB-4 scores were 4.23 (1.99–9.00), and 15.16 (5.18–44.38), respectively, among individuals under 40, and 4.46 (3.03–6.56) and 22.47 (15.11–33.41), respectively, among older individuals. These associations were similar in analyses using APRI. In this cohort of HBsAg-positive individuals, the liver fibrosis scores were associated with increased risks of liver-related mortality in young and older adults. The liver fibrosis scores have a role in predicting liver mortality, even in young adults with HBV. 相似文献
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Ye Young Shin Yoojin Seo Su-Jeong Oh Ji-Su Ahn Min-hye Song Min-Jung Kang Jung-Min Oh Dongjun Lee Yun Hak Kim Eui-Suk Sung Hyung-Sik Kim 《Journal of pineal research》2022,72(1):e12779
The prevalence of head and neck squamous cell carcinoma (HNSCC) has continued to rise for decades. However, drug resistance to chemotherapeutics and relapse, mediated by cancer stem cells (CSCs), remains a significant impediment in clinical oncology to achieve successful treatment. Therefore, we focused on analyzing CSCs in HNSCC and demonstrated the effect of melatonin (Mel) and verteporfin (VP) on SCC-25 cells. HNSCC CSCs were enriched in the reactive oxygen species-low state and in sphere-forming cultures. Combination treatment with Mel and VP decreased HNSCC viability and increased apoptosis without causing significant damage to normal cells. Sphere-forming ability and stem cell population were reduced by co-treatment with Mel and VP, while mitochondrial ROS level was increased by the treatment. Furthermore, the expression of mitophagy markers, parkin and PINK1, was significantly decreased in the co-treated cells. Mel and VP induced mitochondrial depolarization and inhibited mitochondrial function. Parkin/TOM20 was localized near the nucleus and formed clusters of mitochondria in the cells after treatment. Moreover, Mel and VP downregulated the expression of markers involved in epithelial-mesenchymal transition and metastasis. The migration capacity of cells was significantly decreased by co-treatment with Mel and VP, accompanied by the down-regulation of MMP-2 and MMP-9 expression. Taken together, these results indicate that co-treatment with Mel and VP induces mitochondrial dysfunction, resulting in the apoptosis of CSCs. Mel and VP could thus be further investigated as potential therapies for HNSCC through their action on CSCs. 相似文献
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Soojung Hong Ju Hyun Lee Eun Kyeong Chun Kwang-Il Kim Jin Won Kim Se Hyun Kim Yun-Gyoo Lee In Gyu Hwang Jin Young Kim Su-Jin Koh Yoon Ho Ko Seong Hoon Shin In Sook Woo Tae-Yong Kim Ji Yeon Baek Hyun Jung Kim Hyo Jung Kim Myung Ah Lee Jung Hye Kwon Yong Sang Hong Hun-Mo Ryoo Jee Hyun Kim 《The oncologist》2020,25(3):e502-e511