心脏型脂肪酸结合蛋白对急性心肌梗死早期诊断的临床价值研究

Objective To study the clinical value of heart-type fatty acid-binding protein (H-FABP) in early diagnosis of acute myocardial infarction(AMI). Methods Totally 156 patients who were suspicious to be AMI were divided into group A (0～3 h group) and group B (3～6 h group) ac-cording to the visit time. H-FABP,cardiae troponin T (cTnT) and cardiac troponin T (cTnT);Crea-fine kinase isoenzyme-MB (CK-MB) were simultaneously measured at different time-points. The sensi-tivity,specificity and accuracy of the markers were calculated and compared. Results The sensitivity, specificity and accuracy of H-FABP were all the highest among three tumor markers;the sensitivity within 3 hours was 70.7% ,higher than that of cTnT and CK-MB remarkably (P<0.05);the specific-ity was 97.0%; the accuracy was 82.4%, higher than that of cTnT and CK-MB remarkably (P<0.05);while the sensitivity within 3～6 hours was 100.0%, higher than that of cTnT remarkably (P <0.05);the specificity was 92.6%;and the accuracy was 97.6%. Conclusion H-FABP is the most sensitive indicator for early diagnosis of AMI and is of very important value in clinical application.     

心脏型脂肪酸结合蛋白对急性心肌梗死早期诊断的临床价值研究

目的探讨心脏型脂肪酸结合蛋白（H—FABP）在急性心肌梗死（AMI）早期诊断中的临床应用价值。方法将来本院的AMI疑似患者156例，按就诊时发病时间分为2组，分别在发病后0～3、3～6h内同时检测H—FABP、肌钙蛋白T（cTnT）、肌酸激酶同工酶（CK—MB）。计算各项指标的灵敏度、特异性、准确度，并进行比较分析。结果H-FABP在发病0～3h内诊断的灵敏度为70．7％，特异性为97．0％，准确度为82．4％，显著高于cTnT和CK—MB，差异有统计学意义（P〈0．05）。在发病3～6h内诊断的灵敏度为100．0％，显著高于cTnT，差异有统计学意义（P％0．05），特异性为92．6％，准确度为97．6％。结论H—FABP是AMI早期诊断最敏感的指标，具有非常重要的临床应用价值。