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目的 初步探讨应用艾尔巴韦/格拉瑞韦治疗慢性丙型肝炎(CHC)患者的疗效。方法 2017年3月~2018年3月仙桃市第一人民医院感染病科收治的CHC患者82例,被随机分为对照组41例和观察组41例,分别给予聚乙二醇干扰素-α联合利巴韦林治疗和艾尔巴韦/格拉瑞韦治疗,两组均连续治疗24周。采用RT- PCR法检测血清 HCV RNA,采用全基因序列测定法行病毒基因分型。比较两组早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)和持续病毒学应答(SVR)。结果 在治疗结束时,观察组血清丙氨酸氨基转移酶(ALT)水平为(47.9±19.7)U/L,显著低于对照组【(63.5±21.2)U/L,P<0.05】,天冬氨酸氨基转移酶(AST)水平为(55.5±22.3)U/L,显著低于对照组【(81.3±25.8)U/L,P<0.05】;观察组EVR、ETVR和SVR分别为48.8%、63.4%和70.7%,与对照组的41.5%、53.7%和65.8%比,无统计学差异(P>0.05);18例观察组非HCV Ⅰ型感染者EVR、ETVR和SVR分别为88.9%、94.4%和88.9%,显著高于同组23例HCV Ⅰ型感染者(分别为52.2%、60.9%和52.2%, P<0.05),而与对照组15例非HCV Ⅰ型感染者比,无统计学差异(分别为86.7%、93.3%和73.3%, P>0.05);观察组SVR12为87.8%(36/41),显著高于对照组的73.2%(30/41,P<0.05)。结论 应用直接抗病毒(DAA)药物艾尔巴韦/格拉瑞韦治疗CHC患者近期疗效达到,但远期疗效似优于标准治疗方案, 值得临床进一步验证。  相似文献   
3.
金笛  何丽  张海锋 《重庆医学》2016,(29):4068-4070
目的 探讨内质网应激相关蛋白及CXCL12在特发性肺纤维化中的表达及意义.方法 收集荆州市中心医院2004~2014年诊断为特发性肺纤维化且存有活检或手术标本的患者共18例,并收集正常肺组织20例作为对照,通过蛋白免疫印迹法(Western blot)检测内质网应激相关蛋白(GRP78、CHOP)及CXCL12蛋白(SDF-1)的表达,通过逆转录PCR(RT-PCR)检测肺组织中GRP78 mRNA及CXCL12 mRNA的表达.结果 与对照相比,肺纤维化患者肺泡上皮中GRP78、CHOP、CXCL12蛋白表达均上调,且GRP78 mRNA及CXCL12 mRNA也表达上调.结论 内质网应激相关蛋白及CXCL12在特发性肺纤维化的发病过程中起重要作用,可能参与了特发性肺纤维化的发生与发展.  相似文献   
4.
吸入一氧化碳对大鼠脑死亡致肺损伤的影响   总被引:1,自引:1,他引:0  
Objective To investigate the effects of carbon monoxide (CO) inhalation on lung injury induced by brain death (BD) in rats. Methods Adult male Wistar rats weighing 250-300 g were used in this study. The animals were anesthetized with intraperitoneal pentobarbital sodium 60 mg/kg, tracheostomized and mechanically ventilated (VT 10 ml/kg, RR 50 bpm, PEEP 2 cm H2O). A balloon-tip catheter was placed in the cranium. Twenty-four rats in which Fogarty catheter was successfully placed in the cranium without complication were randomly divided into 3 groups ( n = 8 each) : group I sham operation (group S) ; group II BD and group Ⅲ BDCO. BD was induced by increase in intracranial pressure produced by inflating the balloon at the tip of the catheter. In group S the balloon of the catheter was not inflated. The animals inhaled 40% O2 for 150 min. In group BD, BD was induced and confirmed at 30 min after inflation of the balloon. Then 40% O2 was inhaled for 120 min. In group BDCO, 40% O2 and 0.025% CO were inhaled for 120 min after BD was confirmed at 30 min after balloon inflation. At the end of the experiment the animals were killed. Arterial blood samples were obtained for blood gas analysis before anesthesia (basline), immediately after confirmation of BD, and at 30, 60, 90 and 120 min of CO inhalation. Blood was collected for determination of plasma TNF-α, IL-6 and IL-10 concentrations at 120 min of CO inhalation. The lungs were obtained for determination of W/D lung weight ratio, and MPO activity in the lung tissue and microscopic examination. Lung injury scores were calculated. Results PaO2/FiO2 was stable during the 150 min in group S. Brain death significantly decreased PaO2/FiO2 at 30 min after balloon inflation. PaO2/FiO2 was gradually decreasing during the 120 min in group BD. CO inhalation prevented PaO2/FiO2 from decreasing further. W/D lung weight ratio and MPO activity were significantly higher in group BD than in group S and BDCO. The lung injury score (1 = normal, 4= severely injured) and plasma TNF-αα IL-6 and IL-10 concentrations were significantly higher in group BD than in group S. CO inhalation ameliorated the BD-induced lung injury and attenuated the increase in plasma TNF-a and IL-6 concentration. Plasma IL-10 concentration was significantly higher in group BDCO than in group BD. Conclusion CO inhalation can ameliorate acute lung injury induced by BD through decreasing the local and systemic inflammatory response.  相似文献   
5.
目的 探讨七日渐进式早期功能锻炼护理对急性心肌梗死术后患者心功能的影响。方法 选取2018年3月~2021年3月赤峰市医院收治的160例急性心肌梗死术后患者的临床资料进行回顾性分析,按照护理模式的不同分为对照组和观察组,每组80例。对照组给予常规护理模式,观察组给予七日渐进式早期功能锻炼护理,比较两组不同护理方法应用后的护理满意度和生活质量(疾病维度、生理维度、心理维度)评分。结果 观察组护理总满意度显著高于对照组,差异有统计学意义(P<0.05)。干预前,两组疾病维度、生理维度、心理维度等生活质量评分比较,差异无统计学意义(P>0.05);干预后,观察组患者疾病维度、生理维度、心理维度等生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论 七日渐进式早期功能锻炼护理在急性心肌梗死术后患者护理中的应用疗效确切,可显著提升患者的护理服务质量,改善患者生活质量,可在后续患者的辅助性治疗中作为重要护理路径大力应用实施。  相似文献   
6.
王进军  金笛 《护理研究》2008,22(3):269-270
<健康评估>是护理专业学生学习的一门主干课程,是从基础课程转入临床护理课程的桥梁,其任务是使学生通过该课程的学习,能应用会谈技巧进行健康史的采集、独立进行全面系统的身体评估并能识别正常和异常体征、对服务对象的心理社会状况做出整体评估,能解释常用辅助检查的结果、初步学会综合分析资料及提出护理诊断,没有正确的健康评估,就没有正确的护理诊断、护理计划、护理措施[1].我校从2000年在高级护理专业新开了这门课程,并进行了一系列建设和改革,现介绍如下.  相似文献   
7.
Objective To investigate the effects of carbon monoxide (CO) inhalation on lung injury induced by brain death (BD) in rats. Methods Adult male Wistar rats weighing 250-300 g were used in this study. The animals were anesthetized with intraperitoneal pentobarbital sodium 60 mg/kg, tracheostomized and mechanically ventilated (VT 10 ml/kg, RR 50 bpm, PEEP 2 cm H2O). A balloon-tip catheter was placed in the cranium. Twenty-four rats in which Fogarty catheter was successfully placed in the cranium without complication were randomly divided into 3 groups ( n = 8 each) : group I sham operation (group S) ; group II BD and group Ⅲ BDCO. BD was induced by increase in intracranial pressure produced by inflating the balloon at the tip of the catheter. In group S the balloon of the catheter was not inflated. The animals inhaled 40% O2 for 150 min. In group BD, BD was induced and confirmed at 30 min after inflation of the balloon. Then 40% O2 was inhaled for 120 min. In group BDCO, 40% O2 and 0.025% CO were inhaled for 120 min after BD was confirmed at 30 min after balloon inflation. At the end of the experiment the animals were killed. Arterial blood samples were obtained for blood gas analysis before anesthesia (basline), immediately after confirmation of BD, and at 30, 60, 90 and 120 min of CO inhalation. Blood was collected for determination of plasma TNF-α, IL-6 and IL-10 concentrations at 120 min of CO inhalation. The lungs were obtained for determination of W/D lung weight ratio, and MPO activity in the lung tissue and microscopic examination. Lung injury scores were calculated. Results PaO2/FiO2 was stable during the 150 min in group S. Brain death significantly decreased PaO2/FiO2 at 30 min after balloon inflation. PaO2/FiO2 was gradually decreasing during the 120 min in group BD. CO inhalation prevented PaO2/FiO2 from decreasing further. W/D lung weight ratio and MPO activity were significantly higher in group BD than in group S and BDCO. The lung injury score (1 = normal, 4= severely injured) and plasma TNF-αα IL-6 and IL-10 concentrations were significantly higher in group BD than in group S. CO inhalation ameliorated the BD-induced lung injury and attenuated the increase in plasma TNF-a and IL-6 concentration. Plasma IL-10 concentration was significantly higher in group BDCO than in group BD. Conclusion CO inhalation can ameliorate acute lung injury induced by BD through decreasing the local and systemic inflammatory response.  相似文献   
8.
目的根据同型半胱氨酸(Hcy)的水平,对H型、非H型高血压患者以及健康人群的血管的结构功能以及血栓前分子标记物含量变化进行比较并对其机制进行初步探析。方法选取2016至2017年在我院确诊为原发性高血压患者230例作为研究对象,根据其Hcy水平分为两组,其中Hcy10μmol/L称为H型组,共计100例,而Hcy≤10μmol/L则为非H型组,共计130例,同时选取80例健康人群作为对照组,比较组间患者的血管的结构功能以及血栓前分子标记物含量变化。结果相比于非H型组高血压患者,H型组的斑块更大同时数目较多,且颈动脉内中膜厚度较厚,具有显著性差异(P0.05);同时对两组患者的颈动脉斑块进行分级比较,我们发现H型组高血压患者比非H型组在3级程度上所占比例显著增高,0级程度较低;H型高血压组患者的无论是左侧还是右侧的ba PWV相比于非H型组都有明显升高,且差异具有统计学意义(P0.05);与健康人群的对照组相比,可以明显看到两组高血压患者的GMP-140、vWF、Fbg、D-dimer的含量都具有显著上升,差异具有统计学意义(P0.05),与非H型组高血压患者相比而言,H型组患者的血栓前分子标记物也具有明显的上升(P0.05)。结论高水平的Hcy会使原发性高血压患者的动脉血管的结构与功能都发生改变,主要表现在降低患者血管弹性的同时产生血管斑块,并且血栓前分子标记物含量的增高,提示了患者的血液处于高凝状态。  相似文献   
9.
目的评价尿中微量白蛋白测定在冠心病诊治中的意义。方法尿微量白蛋白的检测,采集患者空腹晨尿样送检,尿液样本采取比浊法测定尿白蛋白。结果冠心病组119例尿中微量白蛋白(47.9±23.1)mg/L,阳性91例(76.47%);对照组110例尿中微量白蛋白(13.8±6.4)mg/L,阳性16例(14.55%)。两组尿中微量白蛋白量比较差异有高度显著性(P<0.01),两组尿微白蛋白阳性比较差异有显著性(P<0.05)。结论尿微量白蛋白可以作为判断心血管事件发生及严重程度的指标之一。  相似文献   
10.
Objective To investigate the effects of carbon monoxide (CO) inhalation on lung injury induced by brain death (BD) in rats. Methods Adult male Wistar rats weighing 250-300 g were used in this study. The animals were anesthetized with intraperitoneal pentobarbital sodium 60 mg/kg, tracheostomized and mechanically ventilated (VT 10 ml/kg, RR 50 bpm, PEEP 2 cm H2O). A balloon-tip catheter was placed in the cranium. Twenty-four rats in which Fogarty catheter was successfully placed in the cranium without complication were randomly divided into 3 groups ( n = 8 each) : group I sham operation (group S) ; group II BD and group Ⅲ BDCO. BD was induced by increase in intracranial pressure produced by inflating the balloon at the tip of the catheter. In group S the balloon of the catheter was not inflated. The animals inhaled 40% O2 for 150 min. In group BD, BD was induced and confirmed at 30 min after inflation of the balloon. Then 40% O2 was inhaled for 120 min. In group BDCO, 40% O2 and 0.025% CO were inhaled for 120 min after BD was confirmed at 30 min after balloon inflation. At the end of the experiment the animals were killed. Arterial blood samples were obtained for blood gas analysis before anesthesia (basline), immediately after confirmation of BD, and at 30, 60, 90 and 120 min of CO inhalation. Blood was collected for determination of plasma TNF-α, IL-6 and IL-10 concentrations at 120 min of CO inhalation. The lungs were obtained for determination of W/D lung weight ratio, and MPO activity in the lung tissue and microscopic examination. Lung injury scores were calculated. Results PaO2/FiO2 was stable during the 150 min in group S. Brain death significantly decreased PaO2/FiO2 at 30 min after balloon inflation. PaO2/FiO2 was gradually decreasing during the 120 min in group BD. CO inhalation prevented PaO2/FiO2 from decreasing further. W/D lung weight ratio and MPO activity were significantly higher in group BD than in group S and BDCO. The lung injury score (1 = normal, 4= severely injured) and plasma TNF-αα IL-6 and IL-10 concentrations were significantly higher in group BD than in group S. CO inhalation ameliorated the BD-induced lung injury and attenuated the increase in plasma TNF-a and IL-6 concentration. Plasma IL-10 concentration was significantly higher in group BDCO than in group BD. Conclusion CO inhalation can ameliorate acute lung injury induced by BD through decreasing the local and systemic inflammatory response.  相似文献   
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