张荒生教授“淡以通阳”法治疗湿热痹病

张荒生教授在临床治疗湿热痹病中善用“淡以通阳”法,利用淡渗利湿之品利湿之功效,使湿邪去而热势孤,湿邪去而阳气自然通达于四肢末节。分析张荒生教授运用“淡以通阳”法治疗湿热痹病的学术思想及用药特色。     

痛风颗粒质量标准研究

目的:建立痛风颗粒的质量标准。方法:采用薄层色谱(TLC)法对方中薏苡仁、赤芍、甘草进行定性鉴别;采用高效液相色谱-蒸发光散射检测法测定知母中有效成分菝葜皂苷元的含量。结果:TLC特征明显、专属性强;菝葜皂苷元进样量在0.546～4.368μg范围内与峰面积积分值呈良好的线性关系(r=0.9998);平均回收率为97.74%,RSD=1.3%(n=6)。结论:所建标准可用于痛风颗粒的质量控制。     

保定市"卫生科普资料入病房"活动实施效果评价

对两所市属综合医院实施“卫生科普资料入病房”试点工作，４年的效果调查结果表明，试点组住院患者一般卫生常识的平均及格率为９２５％，对照组为６２４％，两组比较，差别显著。此外，试点组的调查对象中，对卫生科普资料入病房持肯定态度者占８０％，表明卫生资料入病房提高了患者的卫生知识水平，并受到广大患者的欢迎。     

痛风颗粒对尿酸钠关节炎模型大鼠踝关节肿胀度、血清LP-PLA2的影响

目的 探讨痛风颗粒治疗急性痛风性关节炎的作用机制.方法 复制大鼠尿酸钠关节炎模型,观察痛风颗粒对大鼠右踝关节肿胀度、LP-PLA2值的影响.结果 痛风颗粒对大鼠踝关节肿胀有明显的抑制作用,能显著降低大鼠血清LP-PLA2值,与秋水仙碱作用相近.结论 痛风颗粒对急性痛风性关节炎具有治疗作用,其作用机制与抑制血清LP-PLA2的产生有关.     

痹痛定分散片对AA模型骨组织OPG、RANKLmRNA表达的影响

目的通过观察痹痛定分散片对BALB/C小鼠AA模型骨组织中的骨保护素（OPG）、细胞核因子-κB受体活化因子配体（RANKL）mRNA相对表达水平的影响,探讨其防治类风湿关节炎骨质破坏的作用机制。方法取BALB/C种小鼠48只,以Freund’s完全佐剂致炎,复制AA模型,随机分为6组,采用半定量RT-PCR法检测骨组织OPG、RANKLmRNA表达水平的变化。结果各治疗组均能有效降低骨组织RANKLmRNA表达水平,升高OPGmRNA表达水平,RANKL/OPGmRNA比值降低,与正常对照组比较（P〈0.01）,各组与模型对照组比较（P〈0.01）,且痹痛定分散片大剂量、中剂量组优于小剂量组和痹痛定胶囊组。结论痹痛定分散片能明显增加骨组织OPGmRNA表达量,抑制骨组织RANKLmRNA表达量,降低RANKL/OPGmRNA比值,从而有效延缓类风湿关节炎骨质破坏。     

对健康评估课程建设的探讨

<健康评估>是护理专业学生学习的一门主干课程,是从基础课程转入临床护理课程的桥梁,其任务是使学生通过该课程的学习,能应用会谈技巧进行健康史的采集、独立进行全面系统的身体评估并能识别正常和异常体征、对服务对象的心理社会状况做出整体评估,能解释常用辅助检查的结果、初步学会综合分析资料及提出护理诊断,没有正确的健康评估,就没有正确的护理诊断、护理计划、护理措施[1].我校从2000年在高级护理专业新开了这门课程,并进行了一系列建设和改革,现介绍如下.     

止血带对全膝关节置换术中股骨远端旋转定位时髌骨轨迹的影响

Objective To explore, the influence of tourniquet application on patellar tracking with using the surgical transepieondylar axis as distal femur alignment in total knee arthroplasty (TKA). Methods From December 2002 to August 2008, 349 cases (526 knees) of primary TKA were performed. There were 124 males and 225 females with an average age of 68 years from 33 to 84 years. A total of 387 knees had varus deformity and 94 had valgus deformity. All of prosthesis were rotating platform with posterior cruciate ligament retaining provided by Gemini MK Ⅱ. All patients underwent anterior medial parapatellar approach. The surgical transepieondylar axis had been principally used as the distal femur alignment. Patellar tracking was checked with no thumb test. For maltracking ones, we prefered to use a single retinacular closing stitch at the superior medial arthrotomy and deflate tourniquets. Patellar tracking was checked again. Finally, later-al retinaeular releases (LRR) had been performed to obtain optimizing patellar tracking. Results Intraoper-atively, no thumb test were positive in 138 knees, including patellar subluxation (vaigus deformity) in 12 knees and patellar inclining (74 of valgns deformity and 52 of varus deformity) in 126 knees. After using a single retinacular closing stitch at the superior medial arthrotomy and deflating tourniquets, no thumb test were positive in 40 knees, including patellar subluxation (valgus deformity) in 8 knees and patellar inclining (29 of valgns deformity) in 32 knees. The total rate of LRR was 7.6% (40/526), the rate of LRR in valgus deformity was 39.4% (37/94) and that in yarns deformity and no deformity was 0.7% (3/432). Conclusion There was significant influence of tourniquet application on patellar tracking during the TKA. We were not falsely correcting patellar tracking problems with using a single retinaeular closing stitch at the superior me-dial arthrotomy anti deflating tourniquets intraoperatively and reducing the rate of LRR.     

隔物温和灸对膝骨性关节炎家兔软骨细胞及滑膜组织病理学的影响

目的研究隔物温和灸对膝骨性关节炎(Osteoarthritis,OA)家兔软骨细胞及滑膜组织病理学改变的影响,探讨其治疗膝OA的作用机制。方法以36只家兔作为实验动物,随机分为正常组、模型组、药物组和隔物温和灸组。正常组不予处理,模型组、药物组和隔物温和灸组均采用关节制动的方法建立膝OA模型。模型组造模后不予处理,药物组给予仙灵骨葆胶囊的药粉混入饲料中定量喂饲,隔物温和灸组采用隔物温和灸治疗,观察各组治疗后软骨细胞及滑膜组织病理学的改变。结果在软骨积分方面,隔物温和灸组明显优于药物组(P0.01);在软骨及滑膜组织病理学方面,隔物温和灸组和药物组均能有效减轻膝OA家兔软骨退行性改变及滑膜炎症,抑制软骨细胞的增生及炎性细胞浸润。结论隔物温和灸及仙灵骨宝胶囊均能改善膝OA家兔软骨退行性改变及滑膜炎症,起到治疗膝OA的作用,其作用机制可能与减轻软骨细胞的增生及炎性细胞浸润有关,但以隔物温和灸疗效较显著。