全文获取类型
收费全文 | 109128篇 |
免费 | 6838篇 |
国内免费 | 311篇 |
专业分类
耳鼻咽喉 | 1365篇 |
儿科学 | 3923篇 |
妇产科学 | 2570篇 |
基础医学 | 13189篇 |
口腔科学 | 4662篇 |
临床医学 | 9521篇 |
内科学 | 23479篇 |
皮肤病学 | 2704篇 |
神经病学 | 10033篇 |
特种医学 | 3238篇 |
外国民族医学 | 1篇 |
外科学 | 16036篇 |
综合类 | 942篇 |
一般理论 | 84篇 |
预防医学 | 8346篇 |
眼科学 | 2757篇 |
药学 | 7592篇 |
中国医学 | 423篇 |
肿瘤学 | 5412篇 |
出版年
2023年 | 699篇 |
2022年 | 490篇 |
2021年 | 2288篇 |
2020年 | 1481篇 |
2019年 | 2340篇 |
2018年 | 3281篇 |
2017年 | 2304篇 |
2016年 | 2439篇 |
2015年 | 2636篇 |
2014年 | 3463篇 |
2013年 | 5036篇 |
2012年 | 7839篇 |
2011年 | 8675篇 |
2010年 | 4455篇 |
2009年 | 3490篇 |
2008年 | 7302篇 |
2007年 | 7703篇 |
2006年 | 7397篇 |
2005年 | 7328篇 |
2004年 | 6956篇 |
2003年 | 6320篇 |
2002年 | 6078篇 |
2001年 | 1875篇 |
2000年 | 1853篇 |
1999年 | 1432篇 |
1998年 | 895篇 |
1997年 | 651篇 |
1996年 | 570篇 |
1995年 | 569篇 |
1994年 | 503篇 |
1993年 | 468篇 |
1992年 | 547篇 |
1991年 | 491篇 |
1990年 | 461篇 |
1989年 | 408篇 |
1988年 | 386篇 |
1987年 | 327篇 |
1986年 | 325篇 |
1985年 | 318篇 |
1984年 | 407篇 |
1983年 | 345篇 |
1982年 | 373篇 |
1981年 | 341篇 |
1980年 | 339篇 |
1979年 | 235篇 |
1978年 | 213篇 |
1977年 | 202篇 |
1976年 | 158篇 |
1974年 | 160篇 |
1973年 | 144篇 |
排序方式: 共有10000条查询结果,搜索用时 171 毫秒
1.
Buket Bakan Fatih Oltulu Yeliz Y?ld?r?m Altu? Yava?o?lu Sinan Akg?l Nefise ülkü Karabay Yava?o?lu 《Arhiv za higijenu rada i toksikologiju》2023,74(3):207
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.KEY WORDS: biocompatibility, blood biochemistry, genotoxicity, histology, in vivo toxicity, micronucleus test, polymers 相似文献
2.
Clinical Rheumatology - Aimed to evaluate the time elapsed between the onset of early symptoms and the diagnosis of fibromyalgia syndrome (FMS), the delays in diagnosis and frequent physician... 相似文献
3.
Nicolas Penel Sylvie Bonvalot Marie-Cécile Le Deley Antoine Italiano Camille Tlemsani Diane Pannier Clémence Leguillette Jean-Emmanuel Kurtz Maud Toulmonde Julien Thery Daniel Orbach Pascale Dubray-Longeras Benjamin Verret François Bertucci Cécile Guillemet Lucie Laroche Armelle Dufresne Jean-Yves Blay Axel Le Cesne 《International journal of cancer. Journal international du cancer》2023,153(2):407-416
The aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid-type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), managed by surgery, active surveillance or systemic treatments, with pain assessment at diagnosis. Patients were invited to fill QLQ-C30 questionnaire and Hospital Anxiety Depression Scale. Determinants were identified using logistic models. Prognostic value on event-free survival (EFS) was evaluated using the Cox model. Overall, 382 patients were included in the current study (median age: 40.2 years; 117 men). The prevalence of pain was 36%, without significant difference according to first-line treatment (P = .18). In the multivariate analysis, pain was significantly associated with tumor size >50 mm (P = .013) and tumor site (P < .001); pain was more frequent in the neck and shoulder locations (odds ratio: 3.05 [1.27-7.29]). Pain at baseline was significantly associated with poor quality of life (P < .001), depression (P = .02), lower performance status (P = .03) and functional impairment (P = .001); we also observed a nonsignificant association with anxiety (P = .10). In the univariate analysis, baseline pain was associated with poor EFS; the 3-year EFS was 54% in patients with pain compared to 72% in those without pain. After adjustment for sex, age, size and line of treatment, pain was still associated with poor EFS (hazard ratio: 1.82 [1.23-2.68], P = .003). One third of recently diagnosed patients with DF experienced pain, especially those with larger tumors and neck/shoulder locations. Pain was associated with unfavorable EFS after adjustment for the confounders. 相似文献
4.
5.
Chalub Lucas Orbolato Nunes Gabriel Pereira Ferrisse Túlio Morandin Strazzi-Sahyon Henrico Badaoui Dos Santos Paulo Henrique Gomes-Filho João Eduardo Cintra Luciano Tavares Angelo Sivieri-Araujo Gustavo 《Clinical oral investigations》2022,26(4):3343-3356
Clinical Oral Investigations - The objective of this systematic review and meta-analysis (SRM) was to answer the question whether the use of ultrasonic irrigation (UI) results in less postoperative... 相似文献
6.
Crozeta Bruno Monguilhott Lopes Fabiane Carneiro Menezes Silva Renato Silva-Sousa Yara Teresinha Correa Moretti Letícia Freiria Sousa-Neto Manoel Damião 《Clinical oral investigations》2021,25(3):891-899
Clinical Oral Investigations - The aim of this study was to evaluate the efficacy of supplementary techniques (ultrasonic tip/XP-endo Finisher R) in removing remaining filling materials... 相似文献
7.
8.
J. Ripollés-Melchor C. Aldecoa E. Alday-Muñoz S. del Río A. Batalla E. del-Cojo-Peces R. Uña-Orejón J.L. Muñoz-Rodés J.V. Lorente Á.V. Espinosa C. Ferrando-Ortolà J.L. Jover A. Abad-Gurumeta J.M. Ramírez-Rodríguez A. Abad-Motos 《Revista espa?ola de anestesiología y reanimación》2021,68(7):373-383
BackgroundThe optimal regimen for intravenous administration of intraoperative fluids remains unclear. Our goal was to analyze intraoperative crystalloid volume administration practices and their association with postoperative outcomes.MethodsWe extracted clinical data from two multicenter observational studies including adult patients undergoing colorectal surgery and total hip (THA) and knee arthroplasty (TKA). We analyzed the distribution of intraoperative fluid administration. Regression was performed using a general linear model to determine factors predictive of fluid administration. Patient outcomes and intraoperative crystalloid utilization were summarized for each surgical cohort. Regression models were developed to evaluate associations of high or low intraoperative crystalloid with the likelihood of increased postoperative complications, mainly acute kidney injury (AKI) and hospital length of stay (LOS).Results7,580 patients were included. The average adjusted intraoperative crystalloid infusion rate across all surgeries was to 7.9 (SD 4) mL/kg/h. The regression model strongly favored the type of surgery over other patient predictors. We found that high fluid volume was associated with 40% greater odds ratio (OR 1.40; 95% confidence interval1.01-1.95, p = 0.044) of postoperative complications in patients undergoing THA, while we found no associations for the other types of surgeries, AKI and LOSConclusionsA wide variability was observed in intraoperative crystalloid volume administration; however, this did not affect postoperative outcomes. 相似文献
9.
10.