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排序方式: 共有766条查询结果,搜索用时 46 毫秒
1.
Manually controlled targeted prostate biopsy with real‐time fusion imaging of multiparametric magnetic resonance imaging and transrectal ultrasound: An early experience 下载免费PDF全文
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Yuki Mori Daichi Tomonaga Anastasia Kalashnikova Fumihiko Furuya Nozomi Akimoto Masataka Ifuku Yuko Okuno Kaoru Beppu Kyota Fujita Toshihiko Katafuchi Hiroki Shimura Leonid P. Churilov Mami Noda 《Glia》2015,63(5):906-920
l ‐tri‐iodothyronine (3, 3', 5–triiodothyronine; T3) is an active form of the thyroid hormone (TH) essential for the development and function of the CNS. Though nongenomic effect of TH, its plasma membrane–bound receptor, and its signaling has been identified, precise function in each cell type of the CNS remained to be investigated. Clearance of cell debris and apoptotic cells by microglia phagocytosis is a critical step for the restoration of damaged neuron‐glia networks. Here we report nongenomic effects of T3 on microglial functions. Exposure to T3 increased migration, membrane ruffling and phagocytosis of primary cultured mouse microglia. Injection of T3 together with stab wound attracted more microglia to the lesion site in vivo. Blocking TH transporters and receptors (TRs) or TRα‐knock‐out (KO) suppressed T3‐induced microglial migration and morphological change. The T3‐induced microglial migration or membrane ruffling was attenuated by inhibiting Gi/o‐protein as well as NO synthase, and subsequent signaling such as phosphoinositide 3‐kinase (PI3K), mitogen‐activated protein kinase (MAPK)/extracellular signal‐regulated kinase (ERK). Inhibitors for Na+/K+‐ATPase, reverse mode of Na+/Ca2+ exchanger (NCX), and small‐conductance Ca2+‐dependent K+ (SK) channel also attenuated microglial migration or phagocytosis. Interestingly, T3‐induced microglial migration, but not phagocytosis, was dependent on GABAA and GABAB receptors, though GABA itself did not affect migratory aptitude. Our results demonstrate that T3 modulates multiple functional responses of microglia via multiple complex mechanisms, which may contribute to physiological and/or pathophysiological functions of the CNS. GLIA 2015:63:906–920 相似文献
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Kazuyuki Matsushita Kouichi Kitamura Bahityar Rahmutulla Nobuko Tanaka Takayuki Ishige Mamoru Satoh Tyuji Hoshino Satoru Miyagi Takeshi Mori Sakae Itoga Hideaki Shimada Takeshi Tomonaga Minoru Kito Yaeko Nakajima-Takagi Shuji Kubo Chiaki Nakaseko Masahiko Hatano Takashi Miki Masafumi Matsuo Masaki Fukuyo Atsushi Kaneda Atsushi Iwama Fumio Nomura 《Oncotarget》2015,6(7):5102-5117
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Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem-cell transplants 下载免费PDF全文
Imanishi D Miyazaki Y Yamasaki R Sawayama Y Taguchi J Tsushima H Fukushima T Yoshida S Sasaki H Hata T Tomonaga M 《Blood》2007,110(7):2231-2234
To examine whether donor-derived cells could exist in nonhematopoietic tissues of recipients after allogeneic hematopoietic stem-cell transplantation, we examined the patterns of the short tandem repeat (STR) of DNA extracted from fingernail clippings of recipients so that the contamination of blood cells was excluded. All 21 patients reached donor-derived hematopoiesis after transplantation and 20 of them were in remission of the primary diseases at the time of sampling. Compared with the STRs of donor cells, among 9 of 21 patients, DNA extracted from fingernail samples showed coexistence of the donor pattern of the STRs, sharing from 8.9% to 72.9% of total STR areas. Time from transplantation to sampling was from 305 to 2399 days among positive cases. These results demonstrate for the first time the existence of stable contribution of donor cells in fingernails among recipients of allogeneic hematopoietic stem cells. 相似文献
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Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes 总被引:8,自引:0,他引:8
Masako Iwanaga Koichi Furukawa Tatsuhiko Amenomori Hiroyuki Mori Hideo Nakamura Kengo Fuchigami Shimeru Kamihira Hideki Nakakuma & Masao Tomonaga 《British journal of haematology》1998,102(2):465-474
Among acquired stem cell disorders, pathological links between myelodysplastic syndromes (MDS) and aplastic anaemia (AA), and paroxysmal nocturnal haemoglobinuria (PNH) and AA, have been often described, whereas the relationship between MDS and PNH is still unclear. We analysed blood cells of patients with MDS to determine the incidence of the PNH clone, and analysed the PIG-A gene to find mutations characteristic of the PNH clone in MDS. In four (10%) of 40 patients with MDS, flow cytometry showed affected erythrocytes and granulocytes negative for decay-accelerating factor (DAF) and CD59. The population of affected erythrocytes was smaller in MDS patients with PNH clone (MDS/PNH) than in patients with de novo PNH, and haemolysis was milder in the MDS/PNH patients. PIG-A mutations were found in granulocytes of all patients with MDS/PNH. In type and site, the PIG-A mutations were heterogenous, similar to that observed in de novo PNH; i.e. no mutation specific to MDS/PNH was identified. Of note, three of four patients with MDS/PNH each had two PNH clones with different PIG-A mutations, suggesting that PIG-A is mutable in patients with MDS/PNH. In a MDS/PNH patient with trisomy 8, FISH detected a distinct karyotype in a portion of granulocytes with PNH phenotype, indicating that PNH and MDS partly shared affected cells. Thus, MDS predisposes to PNH by creating conditions favourable to the genesis of PNH clone. Considering the increasing prevalence and incidence of MDS, these disorders could be useful for investigating the mechanism by which PIG-A mutation is induced. 相似文献
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Eguchi S Takatsuki M Hidaka M Soyama A Muraoka I Tomonaga T Shimokawa I Kanematsu T 《Digestive diseases and sciences》2011,56(5):1542-1547
Background
A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. 相似文献10.