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排序方式: 共有2987条查询结果,搜索用时 269 毫秒
1.
Cécile Vicier Lillian Werner Jonathan Chipman Lauren C. Harshman Dattatraya H. Patil Raina N. Fichorova Jennifer R. Rider Martin G. Sanda Lorelei A. Mucci Christopher J. Sweeney 《Clinical genitourinary cancer》2019,17(1):32-37
Background
Inflammation and infections have been associated with prostate cancer progression. We assessed whether elevated serum cytokines or T. vaginalis seropositivity at the time of diagnosis was associated with higher grade or lethal prostate cancer.Patients and Methods
Men with localized or metastatic prostate cancer were included in this study. Cytokine serum levels including interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, monocyte chemotactic protein 1 (CCL-2), tumor necrosis factor α, and growth-regulated oncogene α (CXCL-1) using a multiplex enzyme-linked immunosorbent assay and T. vaginalis serology were measured in blood samples at diagnosis.Results
A total of 324 patients were identified at time of localized disease and 118 at time of metastatic disease. Of the 189 patients with localized disease and clinical follow-up data (median, 73 months), 28 developed lethal disease. There was no association between circulating cytokine levels above median concentrations nor T. vaginalis seropositivity and risk of intermediate- to high-risk or lethal prostate cancer.Conclusion
Higher levels of serum cytokine levels and T. vaginalis seropositivity at diagnosis are not associated with high-grade or lethal prostate cancer and do not aid risk stratification of localized prostate cancer. 相似文献2.
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Li Cheryl S. W. Sweeney Kevin Cronenberger Carol 《Cancer chemotherapy and pharmacology》2020,85(3):487-499
Cancer Chemotherapy and Pharmacology - The objectives of this analysis were to characterize the population pharmacokinetics (PK) of PF-06439535 (a bevacizumab biosimilar) and reference bevacizumab... 相似文献
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Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
Melanie D Sweeney Abhay P Sagare Berislav V Zlokovic 《Journal of cerebral blood flow and metabolism》2015,35(7):1055-1068
Alzheimer''s disease (AD) is the most common form of age-related dementias. In addition to genetics, environment, and lifestyle, growing evidence supports vascular contributions to dementias including dementia because of AD. Alzheimer''s disease affects multiple cell types within the neurovascular unit (NVU), including brain vascular cells (endothelial cells, pericytes, and vascular smooth muscle cells), glial cells (astrocytes and microglia), and neurons. Thus, identifying and integrating biomarkers of the NVU cell-specific responses and injury with established AD biomarkers, amyloid-β (Aβ) and tau, has a potential to contribute to better understanding of the disease process in dementias including AD. Here, we discuss the existing literature on cerebrospinal fluid biomarkers of the NVU cell-specific responses during early stages of dementia and AD. We suggest that the clinical usefulness of established AD biomarkers, Aβ and tau, could be further improved by developing an algorithm that will incorporate biomarkers of the NVU cell-specific responses and injury. Such biomarker algorithm could aid in early detection and intervention as well as identify novel treatment targets to delay disease onset, slow progression, and/or prevent AD. 相似文献
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Rebecca E. Graff Andreas Pettersson Rosina T. Lis Natalie DuPre Kristina M. Jordahl Elizabeth Nuttall Jennifer R. Rider Michelangelo Fiorentino Howard D. Sesso Stacey A. Kenfield Massimo Loda Edward L. Giovannucci Bernard Rosner Paul L. Nguyen Christopher J. Sweeney Lorelei A. Mucci 《The Prostate》2015,75(9):897-906
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Association of androgen‐deprivation therapy with excess cardiac‐specific mortality in men with prostate cancer 下载免费PDF全文
David R. Ziehr Ming‐Hui Chen Danjie Zhang Michelle H. Braccioforte Brian J. Moran Brandon A. Mahal Andrew S. Hyatt Shehzad S. Basaria Clair J. Beard Joshua A. Beckman Toni K. Choueiri Anthony V. D'Amico Karen E. Hoffman Jim C. Hu Neil E. Martin Christopher J. Sweeney Quoc‐Dien Trinh Paul L. Nguyen 《BJU international》2015,116(3):358-365