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1.
Adam J. Rosenberg Yiu-Yin Cheung Fei Liu Todd E. Peterson James Silverman Ciaran M. Considine Daniel O. Claassen 《Journal of labelled compounds & radiopharmaceuticals》2022,65(8):223-229
(R)-[18F]MH.MZ ([18F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT2A receptor. To facilitate clinical trials, a fully automated radiosynthesis procedure for [18F]MH.MZ was developed using commercially available materials on the iPhase Flexlab module. The overall synthesis time was 100 min with a radiochemical yield of 7 ± 0.9% (n = 3). The radiochemical purity was greater than 99% for [18F]MH.MZ with a molar activity of 361 ± 57 GBq/μmol (n = 3). The protocol described herein reliably provides [18F]MH.MZ that meets all relevant release criteria for a GMP radiopharmaceutical. 相似文献
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Yinglun Wu Ledibabari M Ngaage Shealinna Ge Erin M. Rada Ronald P. Silverman Yvonne M. Rasko 《International wound journal》2020,17(3):701-707
Wide local excision offers a potential cure for severe axillary hidradenitis suppurativa. However, the gold standard for reconstruction has yet to be defined. Here, we describe our rotation advancement flap technique, which allows for one‐stage closure of large axillary defects, with minimal functional morbidity to the axilla. We performed a retrospective review of all patients who underwent one‐stage surgical management for axillary hidradenitis suppurativa at a single‐centre tertiary care hospital from 2009 to 2018. We identified 34 patients, with a total of 53 operative sites. The majority were female (85%) with a mean age of 31 years and body mass index 35 kg/m2. The median defect size was 84 cm2 and the majority were treated using the rotation advancement flap technique (86%). A quarter of operative sites experienced minor complications with only one requiring re‐operation. At a median follow‐up of 32 months, two (4%) sites showed decreased range of motion. However, all patients had achieved remission without any further recurrence of disease. We describe a one‐stage rotation advancement flap technique for management of moderate to severe hidradenitis suppurativa that achieves a high local cure rate, minimal functional morbidity, and acceptable wound complication rates. 相似文献
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Kaiane Habeshian Robert A. Silverman Cynthia M. C. DeKlotz 《Pediatric dermatology》2019,36(3):411-413
We report a pediatric case of extensive, progressive benign cephalic histiocytosis (BCH) involving the face, trunk, and extremities with response of facial lesions to treatment with topical 1% rapamycin. A split‐face model was used to demonstrate improvement on the treated side versus the untreated side. After physician and parental perception of effectiveness, based in part on photodocumentation, subsequently both cheeks were treated with continued improvement. 相似文献
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Kevin Y. Zhan MD Sidharth V. Puram MD PhD Michael M. Li MD Dustin A. Silverman MD Amit A. Agrawal MD Enver Ozer MD Matthew O. Old MD Ricardo L. Carrau MD James W. Rocco MD PhD Kevin M. Higgins MD MSc Danny J. Enepekides MD MPH Zain Husain MD Stephen Y. Kang MD Antoine Eskander MD ScM 《Cancer》2020,126(6):1295-1305
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