全文获取类型
收费全文 | 4006篇 |
免费 | 188篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 107篇 |
妇产科学 | 64篇 |
基础医学 | 377篇 |
口腔科学 | 118篇 |
临床医学 | 246篇 |
内科学 | 1036篇 |
皮肤病学 | 52篇 |
神经病学 | 143篇 |
特种医学 | 227篇 |
外科学 | 864篇 |
综合类 | 8篇 |
预防医学 | 57篇 |
眼科学 | 42篇 |
药学 | 294篇 |
中国医学 | 13篇 |
肿瘤学 | 516篇 |
出版年
2023年 | 19篇 |
2022年 | 20篇 |
2021年 | 61篇 |
2020年 | 59篇 |
2019年 | 67篇 |
2018年 | 92篇 |
2017年 | 74篇 |
2016年 | 74篇 |
2015年 | 86篇 |
2014年 | 102篇 |
2013年 | 122篇 |
2012年 | 185篇 |
2011年 | 189篇 |
2010年 | 101篇 |
2009年 | 102篇 |
2008年 | 153篇 |
2007年 | 180篇 |
2006年 | 171篇 |
2005年 | 178篇 |
2004年 | 178篇 |
2003年 | 219篇 |
2002年 | 199篇 |
2001年 | 168篇 |
2000年 | 192篇 |
1999年 | 134篇 |
1998年 | 48篇 |
1997年 | 25篇 |
1996年 | 26篇 |
1995年 | 36篇 |
1994年 | 33篇 |
1993年 | 17篇 |
1992年 | 80篇 |
1991年 | 107篇 |
1990年 | 72篇 |
1989年 | 66篇 |
1988年 | 52篇 |
1987年 | 69篇 |
1986年 | 54篇 |
1985年 | 46篇 |
1984年 | 38篇 |
1983年 | 23篇 |
1979年 | 22篇 |
1978年 | 28篇 |
1973年 | 19篇 |
1972年 | 22篇 |
1970年 | 18篇 |
1969年 | 27篇 |
1968年 | 19篇 |
1967年 | 16篇 |
1966年 | 16篇 |
排序方式: 共有4205条查询结果,搜索用时 31 毫秒
1.
Hiroko Yamashita Takashi Morita Michiko Ito Shizuka Okazaki Mototaka Koto Yuri Ichikawa Ryoko Takayama Toshihiko Hoashi Hidehisa Saeki Naoko Kanda 《The Journal of dermatology》2019,46(9):759-769
Psoriasis is characterized by T‐helper 17 cell‐dominant abnormal immunity, and hyperproliferation and abnormal differentiation of epidermal keratinocytes. Some patients are associated with arthritis. Dietary habits can modulate the pathogenesis of psoriasis. Previous studies in Western countries showed higher body mass indices, higher intake of fat and lower intake of fish or vegetables in psoriatic patients compared with the reference groups. We evaluated dietary habits in adult Japanese psoriatic patients, using a validated brief‐type self‐administered dietary history questionnaire, and compared the results to those of age‐ and sex‐matched healthy controls. The results in psoriatic patients with arthritis were compared with those in the patients without. Japanese psoriatic patients showed higher body mass indices, higher intake of fish/shellfish, pulses, sugar/sweeteners, vitamin B12 and vitamin D, and lower intake of meat, compared with those of healthy controls. The logistic regression analysis showed that psoriasis was associated with high body mass index and low intake of meat. The intake of confection in patients with high Psoriasis Area and Severity Index was higher than that in those with low index. The intake of β‐carotene, vitamin A and green/yellow vegetables in psoriatic patients with arthritis were higher than those in the patients without. The dietary habits in Japanese psoriatic patients are rather different from those in Western patients. This is the first study showing the differences in dietary habits between psoriatic patients with arthritis and those without. Further studies should elucidate the relationships of these results with skin and joint lesions in psoriatic patients. 相似文献
2.
3.
4.
5.
Rahul S. Loungani Marat Fudim Dave Ranney Ajar Kochar Marc D. Samsky Desiree Bonadonna Akinobu Itoh Hiroo Takayama Koji Takeda Daniel Wojdyla Adam D. DeVore Mani Daneshmand 《Journal of cardiac failure》2021,27(3):327-337
BackgroundVenoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as a life-saving therapy for patients with cardiovascular collapse, but identifying patients unlikely to benefit remains a challenge.Methods and ResultsWe created the RESCUE registry, a retrospective, observational registry of adult patients treated with VA-ECMO between January 2007 and June 2017 at 3 high-volume centers (Columbia University, Duke University, and Washington University) to describe short-term patient outcomes. In 723 patients treated with VA-ECMO, the most common indications for deployment were postcardiotomy shock (31%), cardiomyopathy (including acute heart failure) (26%), and myocardial infarction (17%). Patients frequently suffered in-hospital complications, including acute renal dysfunction (45%), major bleeding (41%), and infection (33%). Only 40% of patients (n = 290) survived to discharge, with a minority receiving durable cardiac support (left ventricular assist device [n = 48] or heart transplantation [n = 7]). Multivariable regression analysis identified risk factors for mortality on ECMO as older age (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.12–1.42) and female sex (OR, 1.44; 95% CI, 1.02–2.02) and risk factors for mortality after decannulation as higher body mass index (OR 1.17; 95% CI, 1.01-1.35) and major bleeding while on ECMO support (OR, 1.92; 95% CI, 1.23–2.99).ConclusionsDespite contemporary care at high-volume centers, patients treated with VA-ECMO continue to have significant in-hospital morbidity and mortality. The optimization of outcomes will require refinements in patient selection and improvement of care delivery. 相似文献
6.
7.
8.
Hiroshi Watanabe Aya Miyagawa‐Hayashino Tatsuya Imabayashi Mitsuo Kishimoto Masanori Shimomura Kohei Honda Ikoi Omatsu Eri Shimada Masayoshi Inoue Koichi Takayama Eiichi Konishi 《Pathology international》2019,69(12):721-726
We herein describe a rare case of low‐grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic cell component (40% of the tumor), and the central area comprised typical carcinoid (60% of the tumor). The acinic cell component was positive for chromogranin A, synaptophysin and alpha‐1‐antichymotrypsin. Additionally, this component showed focal apical membranous staining for DOG1 and weak positivity for BCL10 and SOX10. Conversely, the carcinoid component was negative for all proteins except for chromogranin A and synaptophysin. Electron microscopy indicated zymogen‐type granules (600–800 nm in diameter) in the acinic cell component, whereas neuroendocrine‐type granules (200–300 nm in diameter) were observed in the carcinoid component. Nuclear NR4A3 immunostaining, which is highly specific for ACC of the salivary gland, was negative in this case. We conclude that the pulmonary carcinoid tumor with true zymogen‐type granules could be seen but showed superficial similarities to ACC based on negative nuclear staining for NR4A3. Pulmonary carcinoids encompass a wide morphological spectrum and may exhibit prominent acinic cell differentiation. 相似文献
9.
10.
Otsuki S Morshed SR Chowdhury SA Takayama F Satoh T Hashimoto K Sugiyama K Amano O Yasui T Yokote Y Akahane K Sakagami H 《Journal of dental research》2005,84(10):919-923
Fluoride has been used to prevent caries in the dentition, but the possible underlying mechanisms of cytotoxicity induction by this compound are still unclear. Since fluoride is known as an inhibitor of glycolytic enzymes, we investigated the possible connection between NaF-induced apoptosis and glycolysis in human promyelocytic leukemia HL-60 cells. NaF-induced apoptotic cell death is characterized by caspase activation, internucleosomal DNA fragmentation, loss of mitochondrial membrane potential, and production of apoptotic bodies. Higher activation of caspases-3 and -9, as compared with that of caspase-8, suggested the involvement of an extrinsic pathway. Utilization of glucose was nearly halted by NaF, whereas that of glutamine was rather enhanced. NaF enhanced the expression of Bad protein, but not that of Bcl-2 and Bax proteins, and reduced HIF-1alpha mRNA expression. Analysis of these data suggests a possible link between glycolysis and apoptosis. 相似文献