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2.
Fatma Çiftci Başak Gülpınar Çetin Atasoy Oya Kayacan Sevgi Saryal 《Advances in medical sciences》2019,64(2):285-291
PurposeCombined pulmonary fibrosis and emphysema (CPFE) has emerged as a new syndrome with characteristics of both fibrosis and emphysema. We determined the impacts of radiologic emphysema severity on pulmonary function tests (PFTs), exercise capacity and mortality.Patients and methodsIPF patients (n = 110) diagnosed at the Chest Diseases Clinic between September 2013 and January 2016 were enrolled in the study and followed up until June 2017. Visual and digital emphysema scores, PFTs, pulmonary artery pressure (sPAP), 6-minute walking test, composite physiologic index (CPI), and survival status were recorded. Patients with emphysema and those with pure IPF were compared.ResultsThe CPFE-group had a significantly greater ratio of men(p < 0.001), lower BMI (p < 0.001), lower mean PaO2 (p = 0.005), higher mean sPAP (p = 0.014), and higher exercise desaturation (p < 0.001). The CPFE group had a significantly higher FVC(L)(p = 0.016), and lower FEV1/FVC ratio (p = 0.002), DLCO, and DLCO/VA ratio(p = 0.03 and p = 0.005, respectively). Lung volumes of the CPFE group had significantly higher VC(p = 0.017), FRC (p < 0.001), RV(p < 0.001), RV/TLC(p < 0.001), and TLC(p < 0.001). There were significant correlations between emphysema scores and FVC (L)(p = 0.01), FEV1/FVC(p = 0.001), DLCO (p = 0.003), VC(p = 0.014), FRC (L)(p < 0.001), RV(p < 0.001), TLC(p < 0.001), and RV/TLC (p < 0.001). Mortality rates were comparable between the two groups. CPI (p = 0.02) and sPAP (p = 0.01) were independent predictors of mortality in patients with CPFE.ConclusionsThe presence and severity of emphysema affects pulmonary function in IPF. Patients with CPFE have reduced diffusion capacity, more severe air trapping, worse muscle weakness, more severe exercise desaturation, and pulmonary hypertension. CPI and pulmonary hypertension are two independent risk factors for mortality in subjects with CPFE. 相似文献
3.
The objectives of this study were to describe the prevalence of pulp chamber calcifications in a sample of Turkish dental
patients and to report associations between presence of pulp chamber calcifications and dental status, gender, age, and cardiovascular
diseases (CVDs). Data were collected through radiographic examination of periapical and bitewing radiographs of 15,326 teeth
from 536 dental patients, comprising 270 male and 266 female patients aged between 13 and 65 years. Definite radiopaque focuses
inside the radiolucent pulp chamber were defined as pulp chamber calcifications. When the pulp chamber was completely radiolucent,
that tooth was scored as tooth without pulp chamber calcification. The dental status was scored as intact, carious, restored,
or restored + carious. Pulp chamber calcifications were identified in 204 (38%) patients examined. Of the 15,326 teeth, 747
(4.8%) had pulp chamber calcifications. Gender and dental status were found to be correlated with the presence of pulp chamber
calcifications. The high prevalence of pulp chamber calcifications in carious, restored, and restored + carious teeth support
the view that the occurrence of pulp chamber calcifications can be a response to long-standing irritants. However, to report
any associations between occurrence of pulp chamber calcifications and different dental or clinical status, further studies
are still needed. 相似文献
4.
The aim of this study was to evaluate the correlations between magnetic resonance imaging (MRI) findings in anterior displacement with reduction (ADDR) and anterior displacement without reduction (ADDWR). Two hundred patients with temporomandibular disorder (TMD) symptoms were examined clinically by a clinician experienced with this disorder. There were 130 joints with ADDR and 45 joints with ADDWR; 88 patients were identified according to the clinical and MRI diagnoses of both observers. The MRI characteristics such as position, signal intensity, morphology of disc, degenerative changes, effusion, scar tissue, avascular necrosis, and condylar hypermobility were evaluated in the individual with ADDR and ADDWR. The Chi-square test was used to determine the correlation between MRI characteristics in the ADDR and the ADDWR. There were significant relationships between degenerative changes and increased signal intensity, degenerative changes and side-way displacement, effusion and the deformation of the disc, effusion and subluxation, increased signal intensity and subluxation, elongation deformation and increased signal intensity, and elongation deformation and side-way displacement in ADDR. There were significant relationships between degenerative changes and effusion, degenerative changes and decreased signal intensity, scar tissue and avascular necrosis, deformation of disc and increased signal intensity, as well as deformation of disc and decreased signal intensity in ADDWR. These MRI findings also correlated with the clinical findings, however, this correlation appears to be a synergistic pattern rather than a set of clear-cut relationships. The correlations between these MRIs and different clinical findings such as pain and dysfunction also must be evaluated. Existing correlations must be considered in the diagnosis and treatment planning of TMD, and signs and symptoms of TMD should be monitored after treatment. 相似文献
5.
Ozlem Altuntas Aydin Mucahit Yemisen Hayat Kumbasar Karaosmanoglu Fatma Sargin Alper Gunduz Bahadir Ceylan Bilgul Mete Nail Ozgunes Dilek Yildiz Sevgi Resat Ozaras Fehmi Tabak 《Hepatitis monthly》2014,14(8)
Background:
Rate of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) varies in different countries. This may be attributable to common transmission routes as well as social, economic, and cultural factors.Objectives:
The purpose of this study was to investigate the prevalence and risk factors of HCV infection among HIV-positive patients in Istanbul, Turkey.Patients and Methods:
Since January 2006 to November 2013, 949 HIV-positive patients that were enrolled in this study by ACTHIV-IST (Action Against HIV in Istanbul) Study Group, which consists of five centers to follow up HIV-positive patients in Istanbul. Epidemiologic and clinical data were collected retrospectively from medical records and were transferred to an HIV database system.Results:
Among 949 patients, 84% were men and the mean age was 37.92 ± 11.54 years (range, 17-79). The most frequent route of transmission was heterosexual intercourse (48.8%), followed by men having sex with men (30.5%). Only nine patients (0.9%) had history of injection drug use (IDU). The prevalence of HIV/HCV coinfection was 0.9% (9:949). The IDU rate was 44.4% (4:9) in patients with HIV/HCV coinfection (three of them were not Turkish citizens), whereas this rate was only 0.6% (5:881) in patients with only HIV infection (P < 0.01). Genotypes 1b, 2a/2c, and 3 were determined in five, one, and two patients, respectively. Genotype could not be determined in one patient. History of residence in a foreign country (P < 0.01) and imprisonment (P < 0.01) were also considered as risk factors in terms of HIV/HCV coinfection.Conclusions:
Prevalence of HIV/HCV coinfection is considerably low in Turkey. The extremely rare prevalence of IDU might have a role in this low prevalence. 相似文献6.
Introduction
Circulating microparticles support thrombin generation. The aim of this study is to determine the indirect microparticle activity and the parameters of thrombin generation in healthy infants.Materials and methods
A total of 85 infants who were brought to follow-up visits were taken into the study. Blood samples were collected. Thrombin generation parameters and indirect microparticle activity were measured.Results
The infants were divided into four groups according to the time of follow-up visits. Mean ages were 1.18 ± 0.19 months in Group 1, 6.15 ± 0.16 months in Group 2, 12.38 ± 0.46 months in Group 3 and 24.53 ± 0.39 months in Group 4, respectively. There was no statistical difference among the age-based groups with respect to the indirect microparticle activity. The lag time and the TTP levels in Group 1 were lower than that found in Group 2. The ETP and peak levels were higher in Group 1 than that of Group 2. The ETP and peak levels in Group 2 were found lower than those found in older children, but the TTP level was found relatively higher. Statistically correlations were found between indirect microparticle activity and all parameters of thrombin generation.Conclusions
The absence of a difference in terms of age-based microparticle levels may suggest that the features of microparticles in healthy children of this age group are similar. Age-dependent changes in thrombin generation parameters may suggest a regulation mechanism for the thrombin generation system over the first years of life. The results may provide mean values for indirect microparticle activity and thrombin generation in this healthy group. 相似文献7.
Sevgi Yavuz Ali Anarat Sabri Acartürk Ahmet Cemil Dalay Erol Kesiktaş Metin Yavuz Tahsin Oğuz Acartürk 《Burns : journal of the International Society for Burn Injuries》2014
Introduction
Neutrophil gelatinase associated lipocalin (NGAL) is a novel predictor of acute kidney injury (AKI), which increases with inflammation. We aimed to assess whether serum NGAL (SNGAL) and urine NGAL (UNGAL) can predict AKI in burned children.Methods
Patients were referred within the 12 h of burn to our center. Serum samples for SNGAL, C-reactive protein (CRP), procalcitonin (PCT) and urine for UNGAL, microalbumine (Umalb), creatinine (Ucr) were obtained at both admission and the 5th day after burn. Blood urea nitrogen (BUN) and serum creatinine (Scr) were examined daily.Results
Twenty-two subjects were enrolled and six (27.2%) of them developed AKI within the 48 h of injury. Burn size and abbreviated burn severity index (ABSI) were significantly increased in patients with AKI. CRP, PCT, SNGAL and UNGAL levels at admission and day 5 were significantly higher in patients with AKI than in those without AKI and controls. Scr was not significant between AKI and non-AKI groups at hospital days 1 and 5. A SNGAL level of 315 ng/ml and a UNGAL level of 100 ng/ml were determined as predictive cut-off values of AKI at admission (sensitivity and specificity: 71.4%, 83.3% and 93.3%, 93.7%, respectively). SNGAL and UNGAL were positively correlated with CRP, PCT, ABSI and Umalb/Ucr.Conclusion
SNGAL and UNGAL are good early predictors of AKI in children with severe burn. NGAL might reflect the severity of burn insult and also could be used as an indicator of inflammation in burn children. 相似文献8.
Sevgi Buyukbese Sarsu Aydin Budeyri 《Burns : journal of the International Society for Burn Injuries》2018,44(5):1210-1227
Introduction
Previously, the majority of wars were fought on remote battlefields between opposing armies due to conflicts preventing civilians from sustaining war-related burn injuries (WRBI). In recent years, WRBI has had a tremendous harmful impact on the pediatric population.This study aimed to investigate the demographics, causes, mechanisms of burns, surgical procedures, the major and minor risk factors affecting mortality, and outcomes of pediatric WRBI amidst the Syrian refugees and the Turkey neighborhood population, treated at our Burn Center.Methods
Out of the 852 filled records, the retrospective cohort was performed with inclusion of 707 pediatric burn patients, 469 Turkey, and 238 Syrian participants, with age 0–17 years. Included in the study were patients admitted to our institution from December 2013 to May 2016, with at least 12 months of consistent follow-up. Independent variables of each patient collected data included age, gender, weight, ethnicity, locations patients coming from, season and reason of burn, type of burn, grade of burn, burnt body regions, total body surface area (TBSA), body surface area (BSA), burnt surface area (BuSA), time delay until admission, and presence of infection at time of admission. The dependent variables were hospitalization periods, surgical procedures of escharotomy, fasciotomy, and grafting, recorded final patient status, and mortality.Results
Syrian children with WRBI (direct-blastic, indirect-unintentional) suffered from higher BSA (mean = 0.91 m2, p = 0.001) than the Turkish children with non-intentional burns (0.89 m2, p = 0.001), P = 0.001. There was a significant relationship between causes of burns, such as hot liquids, fire/flames and blastic injuries among the Syrian (52.9%, 27.3%, p = 0.000) and the Turkish (86.4%, 7.6% P = 0.000) populations, respectively. Although most of the Turkey residents suffered more from hot liquid burns than the Syrians (86.4% vs 52.9%), the majority of mortality occurred with fire/flames and blastic injuries, which was higher among the Syrians (10.10%, p = 0.001) than the Turkish (2.80% p = 0.001). Mortality corresponded with complex and third-degree burns, ranking higher in the Syrian (100%) than in the Turkish (23.3%), which, in turn, related to hospital length of stay (Syrian mean: 9.79, p = 0.001; Turkish mean: 7.83, p = 0.839).Conclusion
Our analysis showed that flame/fire and blast burns were severe and fatal in more pediatric Syrian victims than the Turkey residents due to the severity of war inflicted burned wounds, the living conditions at the refugee camps, and the tent cities. Our present study is significant as our data would alert authorities to predict pediatric WRBI risk factors, burn survivals and casualties, and thus plan strategies to promote training programs for burn management of two distinct populations to reduce risk factors of burn mortality. Burnt surface area (BuSA) is a new parameter we derived to predict mortality risk factors in WRBI. 相似文献9.
10.
Ugur Kesici Sevgi Kesici Hulya Ulusoy Fulya Yucesan Aygen U Turkmen Ahmet Besir Verda Tuna 《International wound journal》2015,12(3):280-284
Studies reporting the need for replacing amino acids such as glutamine (Gln), hydroxymethyl butyrate (HMB) and arginine (Arg) to accelerate wound healing are available in the literature. The primary objective of this study was to present the effects of Gln on tissue hydroxyproline (OHP) levels in wound healing. This study was conducted on 30 female Sprague Dawley rats with a mean weight of 230 ± 20 g. Secondary wounds were formed by excising 2 × 1 cm skin subcutaneous tissue on the back of the rats. The rats were divided into three equal groups. Group C (Control): the group received 1 ml/day isotonic solution by gastric gavage after secondary wound was formed. Group A (Abound): the group received 0·3 g/kg/day/ml Gln, 0·052 g/kg/day/ml HMB and 0·3 g/kg/day/ml Arg by gastric gavage after secondary wound was formed. Group R (Resource): the group received 0·3 g/kg/day/ml Gln by gastric gavage after secondary wound was formed. The OHP levels of the tissues obtained from the upper half region on the 8th day and the lower half region on the 21st day from the same rats in the groups were examined. Statistical analysis was performed using the statistics program SPSS version 17.0. No statistically significant differences were reported with regard to the OHP measurements on the 8th and 21st days (8th day: F = 0·068, P = 0·935 > 0·05; 21st day: F = 0·018, P = 0·983 > 0·05). The increase in mean OHP levels on the 8th and 21st days within each group was found to be statistically significant (F = 1146·34, P = 0·000 < 0·001). We conclude that in adults who eat healthy food, who do not have any factor that can affect wound healing negatively and who do not have large tissue loss at critical level, Gln, Arg and HMB support would not be required to accelerate secondary wound healing. 相似文献