全文获取类型
收费全文 | 1787篇 |
免费 | 138篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 15篇 |
妇产科学 | 13篇 |
基础医学 | 311篇 |
口腔科学 | 23篇 |
临床医学 | 190篇 |
内科学 | 425篇 |
皮肤病学 | 63篇 |
神经病学 | 77篇 |
特种医学 | 148篇 |
外科学 | 189篇 |
综合类 | 2篇 |
预防医学 | 72篇 |
眼科学 | 17篇 |
药学 | 193篇 |
中国医学 | 39篇 |
肿瘤学 | 168篇 |
出版年
2023年 | 15篇 |
2022年 | 8篇 |
2021年 | 69篇 |
2020年 | 36篇 |
2019年 | 57篇 |
2018年 | 87篇 |
2017年 | 55篇 |
2016年 | 79篇 |
2015年 | 119篇 |
2014年 | 109篇 |
2013年 | 147篇 |
2012年 | 188篇 |
2011年 | 174篇 |
2010年 | 129篇 |
2009年 | 101篇 |
2008年 | 97篇 |
2007年 | 101篇 |
2006年 | 79篇 |
2005年 | 83篇 |
2004年 | 50篇 |
2003年 | 59篇 |
2002年 | 39篇 |
2001年 | 8篇 |
2000年 | 10篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1975年 | 3篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有1967条查询结果,搜索用时 468 毫秒
1.
2.
Nur A. Hasan Talayeh Rezayat Peter J. Blatz Seon Young Choi Kimberly J. Griffitt Shah M. Rashed Anwar Huq Nicholas G. Conger Rita R. Colwell D. Jay Grimes 《Journal of clinical microbiology》2015,53(1):9-14
An occurrence of Vibrio cholerae non-O1/O139 gastroenteritis in the U.S. Gulf Coast is reported here. Genomic analysis revealed that the isolate lacked known virulence factors associated with the clinical outcome of a V. cholerae infection but did contain putative genomic islands and other accessory virulence factors. Many of these factors are widespread among environmental strains of V. cholerae, suggesting that there might be additional virulence factors in non-O1/O139 V. cholerae yet to be determined. Phylogenetic analysis revealed that the isolate belonged to a phyletic lineage of environmental V. cholerae isolates associated with sporadic cases of gastroenteritis in the Western Hemisphere, suggesting a need to monitor non-O1/O139 V. cholerae in the interest of public health. 相似文献
3.
J Y Suh Woo H Shim Gyunggoo Cho Xiang Fan Seon J Kwon Jeong K Kim George Dai Xiaoying Wang Young R Kim 《Journal of cerebral blood flow and metabolism》2015,35(6):1033-1043
Vasoreactivity to hypercapnia has been used for assessing cerebrovascular tone and control altered by ischemic stroke. Despite the high prognostic potential, traits of hypercapnia-induced hemodynamic changes have not been fully characterized in relation with baseline vascular states and brain tissue damage. To monitor cerebrovascular responses, T2- and T2*-weighted magnetic resonance imaging (MRI) images were acquired alternatively using spin- and gradient-echo echo plannar imaging (GESE EPI) sequence with 5% CO2 gas inhalation in normal (n=5) and acute stroke rats (n=10). Dynamic relative changes in cerebrovascular volume (CBV), microvascular volume (MVV), and vascular size index (VSI) were assessed from regions of interest (ROIs) delineated by the percent decrease of apparent diffusion coefficient (ADC). The baseline CBV was not affected by middle cerebral artery occlusion (MCAO) whereas the baseline MVV in ischemic areas was significantly lower than that in the rest of the brain and correlated with ADC. Vasoreactivity to hypercapnic challenge was considerably attenuated in the entire ipsilesional hemisphere including normal ADC regions, in which unsolicited, spreading depression-associated increases of CBV and MVV were observed. The lesion-dependent inhomogeneity in baseline MVV indicates the effective perfusion reserve for accurately delineating the true ischemic damage while the cascade of neuronal depolarization is probably responsible for the hemispherically lateralized changes in overall neurovascular physiology. 相似文献
4.
5.
JeongYun Choi Haeseung Lee EunJi Kwon HyeonJoon Kong OkSeon Kwon HyukJin Cha 《Molecular oncology》2021,15(2):679
The acquisition of chemoresistance remains a major cause of cancer mortality due to the limited accessibility of targeted or immune therapies. However, given that severe alterations of molecular features during epithelial‐to‐mesenchymal transition (EMT) lead to acquired chemoresistance, emerging studies have focused on identifying targetable drivers associated with acquired chemoresistance. Particularly, AXL, a key receptor tyrosine kinase that confers resistance against targets and chemotherapeutics, is highly expressed in mesenchymal cancer cells. However, the underlying mechanism of AXL induction in mesenchymal cancer cells is poorly understood. Our study revealed that the YAP signature, which was highly enriched in mesenchymal‐type lung cancer, was closely correlated to AXL expression in 181 lung cancer cell lines. Moreover, using isogenic lung cancer cell pairs, we also found that doxorubicin treatment induced YAP nuclear translocation in mesenchymal‐type lung cancer cells to induce AXL expression. Additionally, the concurrent activation of TGFβ signaling coordinated YAP‐dependent AXL expression through SMAD4. These data suggest that crosstalk between YAP and the TGFβ/SMAD axis upon treatment with chemotherapeutics might be a promising target to improve chemosensitivity in mesenchymal‐type lung cancer.
Abbreviations
- AUC
- area under the curve
- AXL
- AXL receptor tyrosine kinase
- BCL2
- B‐cell lymphoma 2
- CTD2
- cancer target discovery and development
- CTGF
- connective tissue growth factor
- DEG
- differentially expressed genes
- DOXO
- doxorubicin
- EMT
- epithelial–mesenchymal transition
- Eto
- etoposide
- FDA
- Food and Drug Administration
- ITGB3
- integrin beta‐3
- MAPK
- mitogen‐activated protein kinase
- MMP2
- matrix metalloproteinase‐2
- MMP9
- matrix metalloproteinase‐9
- mRNA
- messenger RNA
- NF‐κB
- nuclear factor kappa‐light‐chain‐enhancer of activated B cells
- SBE
- SMAD binding element
- SERPINE1
- serpin family E member 1
- siRNA
- small interfering RNA
- ssGSEA
- single‐sample gene set enrichment analysis
- TCGA
- The Cancer Genome Atlas
- TGFβ
- transforming growth factor beta
- YAP
- Yes‐associated protein
- YAP8SA
- mutants of inhibitory phosphorylation site at eight serine to Alanine of YAP
- ZEB1
- zinc finger E‐box binding homeobox 1
- ZEB2
- zinc finger E‐box‐binding homeobox 2
6.
Kwang Yeol Paik Ji Seon Oh Eung Kook Kim 《Asian journal of surgery / Asian Surgical Association》2021,44(4):636-640
BackgroundIt is new clinical interest higher serum amylase level with pancreatitis after pancreaticoduodenectomy (PD) correlates with postoperative pancreatic fistula (POPF). Nevertheless, its evidence and study were scarce. We aimed to investigate correlation of serum amylase level immediate after PD and POPF occurrence.MethodsOf 163 patients who underwent PD at between January 2009 and December 2019, retrospective analysis was conducted to identify risk factors including serum amylase level immediate after PD for POPF occurrence.ResultsOverall incidence of POPF (25/163) was 15.3%. The patients occurred a POPF had significantly higher level of serum amylase on POD0 compared to in whom without a POPF (414 vs 253, p < 0.001). In univariate analysis, ASA classification, post pancreatectomy acute pancreatitis (POAP, serum amylase on POD0 >285IU/L) and Fistula Risk Grade were correlated with POPF occurrence. In multivariable analysis, Fistula risk grade and POAP were significantly associated with developing POPF.ConclusionIn patients with higher serum amylase (>285IU/L) on POD0 with higher fistula risk grade, comprehensive management to achieve mitigation of POPF is important. 相似文献
7.
8.
9.
10.
A comparative evaluation of different compensating curves in the lingual and labial techniques using 3D FEM. 总被引:7,自引:0,他引:7
Sang Jin Sung Hyoung Seon Baik Yoon Shik Moon Hyung Seog Yu Young Soo Cho 《American journal of orthodontics and dentofacial orthopedics》2003,123(4):441-450
Because adults dislike the visibility of orthodontic appliances, the use of the lingual orthodontic technique has increased over time. But few studies compare tooth movement of the lingual technique with that of the labial technique. In this study, human mandibular left teeth were aligned, and a 3-dimensional finite element model was made (consisting of 19382 nodes and 12150 elements). To compare the effect of compensating curves on canine retraction between the lingual and the labial orthodontic techniques, the compensating curve was increased on the.016-in stainless steel labial or lingual archwire, and a 150-g force was applied distally on the canine. The relative direction and the amount of tooth displacement of the finite element model were compared on a schematic displacement graph (magnified 10,000 times), and the compressive stress distributed on the root surface was observed. The pattern of tooth movement (with or without a compensating curve) was different between the labial and the lingual techniques. As the amount of compensating curve increased (0, 2, and 4 mm) in the archwire, the rotation and the distal tipping of the canine was reduced. The antitip and antirotation action of compensating curve on the canine retraction was greater in the labial archwire than in the lingual archwire. 相似文献