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Yasuhiro Tsubokura Ryuichi Hasegawa Sunao Aso Toshio Kobayashi Takayuki Koga Satsuki Hoshuyama 《Drug and chemical toxicology》2018,41(4):492-500
We have conducted animal toxicity tests of chemicals for a chemical safety program implemented by the Ministry of Economy, Trade and Industry of Japan. Here we conducted a combined repeated-dose and reproductive/developmental toxicity screening test of benzene, 1,1′-oxybis-, tetrapropylene derivs. (BOTD). BOTD was administered to 9-week-old Crl:CD(SD) male and female rats by gavage at 0, 40, 200, or 1000?mg/kg/day. Males were treated for 42 days including mating period. Females were treated for 42–53 days through the premating, mating, pregnancy, and until Day 4 of lactation periods. Increases in prothrombin time and activated partial thromboplastin time values were observed only in males at 200 and 1000?mg/kg/day. Hypertrophy of centrilobular hepatocytes was observed with increased liver weight in both sexes at 200 and 1000?mg/kg/day, but there was no histologic evidence of hepatotoxicity. Diffuse hypertrophy of follicular cells in thyroid glands was observed in females at 200?mg/kg/day and in both sexes at 1000?mg/kg/day, with an increased blood cholesterol level in females at 1000?mg/kg/day. The conception index was decreased for females at 1000?mg/kg/day; and no abnormalities were detected in the reproductive indices of implantation, delivery, or pups’ condition, although a slight increase in the pups’ body weight was noted at birth. Our data indicate a no-observed-adverse-effect level of 40?mg/kg/day for repeated-dose toxicity on the basis of the prolongation of blood coagulating time, and of 200?mg/kg/day for reproductive/developmental toxicity on the basis of the decreased conception index. 相似文献
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Satsuki?KumasakaEmail author Kensuke?Asa Ryota?Kawamata Toshio?Okada Masayasu?Miyake Isamu?Kashima 《Oral Radiology》2005,21(1):38-40
Objectives Using cancellous bone blocks of racehorses, the relationship between bone mineral density (BMD), which indicates bone strength, and stiffness in bone fracture occurrences was studied.Methods Two groups of cancellous bone blocks were prepared: a fractured group, using the first phalangeal bones of seven racehorses with sagittal fractures; and a nonfractured group, using the first phalangeal bones of nine autopsied racehorses without any fractures. By a peripheral quantitative computed tomography scan, the BMD values were shown as color images and evaluated. In addition, the BMD values obtained from the fractured and nonfractured groups were compared with the stiffness values obtained from a compression test.Results The difference between the average BMD values of the fractured and nonfractured groups was easily observed on the BMD color-conversion display image. The average BMD of the fractured group (472.1 mg/cm3) was significantly higher than that of the nonfractured group (284.5 mg/cm3, P = 0.005). Moreover, the average stiffness of the fractured group (5564.5 N/cm) was significantly higher than that of the nonfractured group (3808.6 N/cm, P = 0.008).Conclusion These results suggest that the occurrence of a fracture does not depend on the BMD or the bone stiffness value. 相似文献
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Satsuki Kumasaka DDS PhD Kensuke Asa DDS Atsushi Watanabe DDS Isamu Kashima DDS PhD 《Oral Radiology》2003,19(2):41-46
Improvement in bone mineral density (BMD) in the femur after administration of eel bone powder (EBP) was evaluated in ovariectomized
(OVX) mice. Female ICR mice were given ovariectomies or sham operations at 9 weeks of age, then housed for 2 weeks during
which they were allowed free access to a normal diet. Subsequently, the mice were divided into 3 groups: sham-operated mice
fed a normal diet, OVX mice fed a normal diet, and OVX mice fed a diet containing EBP. After the mice in these 3 groups had
been housed for 2 months (during which time they were allowed free access to their respective diets), they were dissected
and analyzed. The BMD values in the removed femurs were measured by peripheral quantitative computed tomography (pQCT). Femoral
total and femoral cancellous BMD values were higher in the EBP-treated group than in the nontreated group. Total BMD: the
value in the EBP-treated group was 573 mg/cm3, and that in the non-treated group was 451 mg/cm3 (p<0.05). Cancellous BMD: the value in the EBP-treated group was 242 mg/cm3, and that in the non-treated group was 143 mg/cm3 (p<0.05). However, cortical BMD values did not significantly differ between the EBP-treated group and the non-treated group.
Cortical BMD: The value in the EBP-treated group was 1891 mg/cm3, and that in the non-treated group was 1900 mg/cm3. pQCT was used to measure the cortical and cancellous BMD in the long bones. By use of a color conversion technique to display
BMD, regional changes in the long bones can be expressed and easily measured.
It has been well documented that EBP is effective for improvement or prevention of BMD reduction associated with OVX. 相似文献
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Hiroyuki Nishi Koichi Toda Shigeru Miyagawa Yasushi Yoshikawa Satsuki Fukushima Daisuke Yoshioka Yoshiki Sawa 《General thoracic and cardiovascular surgery》2018,66(4):214-219