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排序方式: 共有594条查询结果,搜索用时 15 毫秒
1.
Virendra Kumar Tarun Kumar Sachan Pragya Sharma Krishna Dutta Rawat 《Ultrastructural pathology》2015,39(1):38-48
The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic acid albumin dextrose catalase (OADC) enrichment and at different temperatures: 30, 37 and 42?°C. Four hundred mycobacterial isolates were taken. The biomass of each biofilm was quantified using a modified microtiter plate assay method. Isolates were divided into those that formed fully established biofilms, moderately attached biofilms and weakly adherent biofilms by comparison with a known biofilm-forming strain. The large quantity of biofilm was produced by Mycobacterium smegmatis at temperature 37 and 42?°C as compared to 30?°C. Mycobacterium fortuitum and M. avium developed large amount of biofilm at 30?°C as compared to 37 and 42?°C. Mycobacterium tuberculosis developed strong biofilm at 37?°C and no biofilm at 30 and 42?°C in Sauton’s media. The selected non-tuberculous mycobacteria and H37Rv developed strong biofilm in the presence of OADC enrichment in Sauton’s medium. Microscopic examination of biofilms by scanning electron microscopy revealed that poorly adherent biofilm formers failed to colonize the entire surface of the microtiter well. While moderately adherent biofilm formers grew in uniform monolayers but failed to develop a mature three-dimensional structure. SEM analysis of an isolate representative of the group formed fully established biofilms with a textured, multi-layered, three-dimensional structure. 相似文献
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Ram N. Kushwaha Rohit Srivastava Akansha Mishra Arun K. Rawat Arvind K. Srivastava Wahajul Haq Seturam B. Katti 《Chemical biology & drug design》2015,85(4):439-446
Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, 1-(2-(4-(7-Chloro-4-quinolyl)piperazin-1-yl)acetyl)pyrrolidine ( 2g ) was identified as a potential DPP-IV inhibitor exhibiting better inhibitory activity than P32/98, reference inhibitor. The in vivo studies carried out in STZ and db/db mice models indicated that the compound 2g showed moderate antihyperglycemic activity as compared to the marketed drug Sitagliptin. A two-week repeated dose study in db/db mice revealed that compound 2g significantly declined blood glucose levels with no evidence of hypoglycemia risk. Furthermore, it showed improvement in insulin resistance reversal and antidyslipidemic properties. Molecular docking studies established good binding affinity of compound 2g at the DPP-IV active site and are in favor of the observed biological data. These data collectively suggest that compound 2g is a good lead molecule for further optimization studies. 相似文献
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Govind K Makharia Chris J J Mulder Khean Lee Goh Vineet Ahuja Julio C Bai Carlo Catassi Peter H R Green Siddhartha Datta Gupta Knut E A Lundin Balakrishnan Siddartha Ramakrishna Ramakant Rawat Hanish Sharma Ajit Sood Chikako Watanabe Peter R Gibson World Gastroenterology Organization‐Asia Pacific Association of Gastroenterology Working Party on Celiac Disease 《Journal of gastroenterology and hepatology》2014,29(4):666-677
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Praveen Kumar Verma Krishna Kumar Rawat Ranjeet Kumar 《Proceedings of the National Academy of Sciences, India. Section B.》2014,84(3):811-813
A rare bryophyte, Anthoceros subtilis Steph., earlier reported in India only from Western Ghats, (Karnataka and Maharashtra), Gujarat, Rajasthan and elsewhere in world from China, Thailand and Vietnam, has been discovered from southern Brahmaputra flood plains of Assam. 相似文献
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