首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   54110篇
  免费   3182篇
  国内免费   668篇
耳鼻咽喉   966篇
儿科学   655篇
妇产科学   827篇
基础医学   9380篇
口腔科学   1328篇
临床医学   4633篇
内科学   9884篇
皮肤病学   1839篇
神经病学   3822篇
特种医学   2966篇
外科学   7433篇
综合类   252篇
一般理论   17篇
预防医学   2518篇
眼科学   1204篇
药学   4939篇
中国医学   623篇
肿瘤学   4674篇
  2023年   299篇
  2022年   200篇
  2021年   1271篇
  2020年   936篇
  2019年   1204篇
  2018年   1600篇
  2017年   1242篇
  2016年   1730篇
  2015年   2566篇
  2014年   3059篇
  2013年   3507篇
  2012年   5319篇
  2011年   4816篇
  2010年   2813篇
  2009年   2386篇
  2008年   3415篇
  2007年   3161篇
  2006年   2665篇
  2005年   2368篇
  2004年   2024篇
  2003年   1688篇
  2002年   1435篇
  2001年   1368篇
  2000年   1259篇
  1999年   909篇
  1998年   357篇
  1997年   251篇
  1996年   221篇
  1995年   198篇
  1994年   172篇
  1993年   147篇
  1992年   340篇
  1991年   325篇
  1990年   294篇
  1989年   276篇
  1988年   270篇
  1987年   259篇
  1986年   180篇
  1985年   173篇
  1984年   122篇
  1983年   114篇
  1982年   60篇
  1981年   64篇
  1979年   81篇
  1978年   71篇
  1976年   50篇
  1975年   55篇
  1974年   60篇
  1973年   51篇
  1972年   50篇
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Coates  Laura C.  Mease  Philip  Kronbergs  Andris  Helt  Cameron  Sandoval  David  Park  So Young  Combe  Bernard  Nash  Peter  Deodhar  Atul 《Clinical rheumatology》2022,41(10):3035-3047
Clinical Rheumatology - To evaluate the three-year efficacy and safety of ixekizumab with and without concomitant conventional synthetic disease-modifying antirheumatic drug (csDMARD) use in...  相似文献   
3.
The International Journal of Cardiovascular Imaging - The new version of EchoPAC platform was recently developed by General Electronics (GE) to provide ‘vendor-independent’...  相似文献   
4.
Journal of Digital Imaging - The purpose of this study was to evaluate the feasibility of translation of RadLex lexicon from English to German performed by Google Translate, using the RadLex...  相似文献   
5.
Ahn  Sung Soo  Ha  Jang Woo  Park  Yong-Beom  Lee  Sang-Won 《Clinical rheumatology》2022,41(11):3429-3437
Clinical Rheumatology - Birmingham vasculitis activity score (BVAS) version 3 (BVAS 3.0) and BVAS/granulomatosis with polyangiitis (BVAS/GPA) are used as indicators of disease activity in...  相似文献   
6.

Asian American immigrant (AAI) women may have suboptimal 24-h activity patterns due to traditional gender role and caregiving responsibilities. However, little is known about their objectively-measured activity. We measured AAI women’s 24-h activity patterns using accelerometry and examined cultural correlates of time in sedentary behavior (SB), light intensity physical activity (LIPA), moderate-to-vigorous physical activity (MVPA) and sleep. Seventy-five AAI women completed surveys on acculturation (years of U.S. residency and English proficiency), discrimination, and sleep quality, and 7 days of wrist- and hip-accelerometer monitoring. Linear regression was conducted controlling for age, BMI, and education. We also compared activity patterns across Asian subgroups (East, Southeast, South Asians). On average, AAI women had 33 min of MVPA, 6.1 h of LIPA, 10 h of SB, and 5.3 h of sleep per day. South Asian women had the longest SB and the shortest sleep and MVPA hours. English proficiency was negatively related to MVPA (p?=?0.03) and LIPA (p?<?0.01). Years of U.S. residency was positively related to SB (p?=?0.07). Discrimination was related to shorter (p?=?0.03) and poorer quality sleep (p?=?0.06). Culturally-tailored programs targeting SB and sleep and integrating coping strategies against discrimination could help optimize AAI women’s 24-h activity patterns.

  相似文献   
7.
Journal of Clinical Immunology - Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4+...  相似文献   
8.
Post-induction hypotension is common and associated with postoperative complications. We hypothesised that pneumatic leg compression reduces post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy. In this double-blind randomised study, patients were allocated randomly to the pneumatic leg compression group (n = 50) or control (n = 50). In the intervention group, pneumatic leg compression was initiated before induction of anaesthesia. In the control group, pneumatic leg compression was initiated 20 min after anaesthesia induction. The primary outcome was the incidence of post-induction hypotension in these groups. Post-induction hypotension was defined as systolic blood pressure < 90 mmHg during the first 20 min after induction. Haemodynamic variables and area under the curve of post-induction systolic blood pressure over time were assessed. Complications associated with pneumatic leg compression were recorded, including: peripheral neuropathy; compartment syndrome; extensive bullae beneath the leg sleeves; and pulmonary thromboembolism. The incidence of post-induction hypotension decreased in the pneumatic leg compression group compared with that in the control group; 5 (10%) vs. 29 (58%), respectively, p < 0.001. In the pneumatic leg compression group, the lowest systolic, diastolic and mean blood pressures 20 min after induction of anaesthesia were significantly greater than the control group. Pneumatic leg compression resulted in an increased area under the curve of systolic blood pressure in the first 20 min after induction, p = 0.001. There were no pneumatic leg compression-related complications. Pneumatic leg compression reduced post-induction hypotension in elderly patients undergoing robot-assisted laparoscopic prostatectomy, suggesting that it is an effective and safe intervention to prevent post-induction hypotension among elderly patients undergoing general anaesthesia.  相似文献   
9.
10.

Organ-on-chip or micro-engineered three-dimensional cellular or tissue models are increasingly implemented in the study of cardiovascular pathophysiology as alternatives to traditional in vitro cell culture. Drug induced cardiotoxicity is a key issue in drug development pipelines, but the current in vitro and in vivo studies suffer from inter-species differences, high costs, and lack of reliability and accuracy in predicting cardiotoxicity. Microfluidic heart-on-chip devices can impose a paradigm shift to the current tools. They can not only recapitulate cardiac tissue level functionality and the communication between cells and extracellular matrices but also allow higher throughput studies conducive to drug screening especially with their added functionalities or sensors that extract disease-specific phenotypic, genotypic, and electrophysiological information in real-time. Such electrical and mechanical components can tailor the electrophysiology and mechanobiology of the experiment to better mimic the in vivo condition as well. Recent advancements and challenges are reviewed in the fabrication, functionalization and sensor assisted mechanical and electrophysiological measurements, numerical and computational modeling of cardiomyocytes’ behavior, and the clinical applications in drug screening and disease modeling. This review concludes with the current challenges and perspectives on the future of such organ-on-chip platforms.

  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号