全文获取类型
收费全文 | 1394篇 |
免费 | 138篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 52篇 |
妇产科学 | 29篇 |
基础医学 | 320篇 |
口腔科学 | 11篇 |
临床医学 | 135篇 |
内科学 | 307篇 |
皮肤病学 | 36篇 |
神经病学 | 151篇 |
特种医学 | 30篇 |
外科学 | 138篇 |
综合类 | 2篇 |
预防医学 | 93篇 |
眼科学 | 9篇 |
药学 | 91篇 |
中国医学 | 11篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 9篇 |
2022年 | 6篇 |
2021年 | 23篇 |
2020年 | 17篇 |
2019年 | 34篇 |
2018年 | 28篇 |
2017年 | 26篇 |
2016年 | 26篇 |
2015年 | 49篇 |
2014年 | 63篇 |
2013年 | 59篇 |
2012年 | 132篇 |
2011年 | 96篇 |
2010年 | 72篇 |
2009年 | 58篇 |
2008年 | 94篇 |
2007年 | 90篇 |
2006年 | 95篇 |
2005年 | 105篇 |
2004年 | 106篇 |
2003年 | 93篇 |
2002年 | 80篇 |
2001年 | 13篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 10篇 |
1994年 | 17篇 |
1993年 | 15篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有1538条查询结果,搜索用时 31 毫秒
1.
2.
3.
van Deursen Dagmar N. van den Heuvel Odile A. Booij Jan Berendse Henk W. Vriend Chris 《Journal of neurology》2020,267(7):1922-1930
Journal of Neurology - Autonomic dysfunction is a common non-motor symptom in Parkinson’s disease (PD). Dopamine and serotonin are known to play a role in autonomic regulation, and,... 相似文献
4.
Sylviane Darquy Grégoire Moutel Odile Jullian Stéphanie Barré Nathalie Duchange 《BMC women's health》2018,18(1):192
Background
The French national cancer institute (INCa) conducted a series of studies to assist decision-making in view of the implementation of organised cervical cancer screening that will be launched in 2018. The programme will concern all women aged 25–65 and targeted interventions will be developed for underscreened populations. This is an evolution from an equality-based approach to a step-by-step strategy of equity aiming to tackle health cancer inequalities that are avoidable and represents unfair differences. Here we present the work of the expert-group in ethics drafted by INCa to review the ethical issues prior to the programme implementation.Discussion
We discuss the value of such a strategy and presents reflections with regard to issues of stigmatization, respect for individual freedom and autonomy. Indeed, the balance has to be found between the search for beneficence and the potential occurrence of perverse effects, which should be considered with particular attention.Conclusion
Moving toward an equity-oriented policy under a strategy of proportionate universalism faces a number of challenges, thus an overview of ethics and social sciences must be an integral part of the process.5.
Chaim Huyser Odile A. van den Heuvel Lidewij Wolters Else de Haan Ramon Lindauer Dick J. Veltman 《The world journal of biological psychiatry》2014,15(6):443-452
Objectives. To identify neurodevelopmental differences in regional brain volume between medication-free paediatric obsessive–compulsive disorder (OCD) patients and controls at 2-year follow-up after cognitive behavioural therapy. Methods. We assessed 17 medication-free paediatric OCD patients (mean age 13.8 years; SD = 2.8; range 8.2–19.0) and 20 controls, matched on age and gender, with T1-weighted MR scans in a repeated measures design at three time points with intervals of 6 months and 2 years. Voxel based morphometry (VBM) was used to test whole brain voxel-wise for the effects of diagnosis and time on regional grey matter (GM) and white matter volumes. Results. GM volume of the orbitofrontal cortex showed a group × time interaction effect, driven by an increase of GM volume over the whole time period in OCD patients and a decrease in controls. When splitting the groups in two age groups (8–12 and 13–19 years) this interaction effect was only seen in the youngest age group. Conclusions. Neuroimaging findings in paediatric OCD after 6 months of CBT in the GM volume of the orbital frontal cortex are still present at 2-year follow-up. 相似文献
6.
Frontostriatal system in planning complexity: a parametric functional magnetic resonance version of Tower of London task 总被引:4,自引:0,他引:4
van den Heuvel OA Groenewegen HJ Barkhof F Lazeron RH van Dyck R Veltman DJ 《NeuroImage》2003,18(2):367-374
In the present study, we sought to investigate which brain structures are recruited in planning tasks of increasing complexity. For this purpose, a parametric self-paced pseudo-randomized event-related functional MRI version of the Tower of London task was designed. We tested 22 healthy subjects, enabling assessment of imaging results at a second (random effects) level of analysis. Compared with baseline, planning activity was correlated with increased blood oxygenation level-dependent (BOLD) signal in the dorsolateral prefrontal cortex, striatum, premotor cortex, supplementary motor area, and visuospatial system (precuneus and inferior parietal cortex). Task load was associated with increased activity in these same regions. In addition, increasing task complexity was correlated with activity in the left anterior prefrontal cortex, a region supposed to be specifically involved in third-order higher cognitive functioning. 相似文献
7.
Chris Vriend MSc Anna H. Nordbeck BSc Jan Booij MD PhD Ysbrand D. van der Werf PhD Tommy Pattij PhD Pieter Voorn PhD Pieter Raijmakers MD Elisabeth M.J. Foncke MD PhD Elsmarieke van de Giessen MD PhD Henk W. Berendse MD PhD Odile A. van den Heuvel MD PhD 《Movement disorders》2014,29(7):904-911
Impulse control disorders (ICD) are relatively common in Parkinson's disease (PD) and generally are regarded as adverse effects of dopamine replacement therapy, although certain demographic and clinical risk factors are also involved. Previous single‐photon emission computed tomography (SPECT) studies showed reduced ventral striatal dopamine transporter binding in Parkinson patients with ICD compared with patients without. Nevertheless, these studies were performed in patients with preexisting impulse control impairments, which impedes clear‐cut interpretation of these findings. We retrospectively procured follow‐up data from 31 medication‐naïve PD patients who underwent dopamine transporter SPECT imaging at baseline and were subsequently treated with dopamine replacement therapy. We used questionnaires and a telephone interview to assess medication status and ICD symptom development during the follow‐up period (31.5 ± 12.0 months). Eleven patients developed ICD symptoms during the follow‐up period, eight of which were taking dopamine agonists. The PD patients with ICD symptoms at follow‐up had higher baseline depressive scores and lower baseline dopamine transporter availability in the right ventral striatum, anterior‐dorsal striatum, and posterior putamen compared with PD patients without ICD symptoms. No baseline between‐group differences in age and disease stage or duration were found. The ICD symptom severity correlated negatively with baseline dopamine transporter availability in the right ventral and anterior‐dorsal striatum. The results of this preliminary study show that reduced striatal dopamine transporter availability predates the development of ICD symptoms after dopamine replacement therapy and may constitute a neurobiological risk factor related to a lower premorbid dopamine transporter availability or a more pronounced dopamine denervation in PD patients susceptible to ICD. © 2014 International Parkinson and Movement Disorder Society 相似文献
8.
Montserrat Ruiz Mlina Bgou Nathalie Launay Pablo RaneaRobles Patrizia Bianchi Jone LpezErauskin Laia Morat Cristina Guilera Brengre Petit Catherine VaursBarriere Cline GuretGonthier MarieNoëlle BonnetDupeyron Stphane Fourcade Johan Auwerx Odile BoespflugTanguy Aurora Pujol 《Brain pathology (Zurich, Switzerland)》2018,28(5):611
Pelizaeus‐Merzbacher disease (PMD) is a fatal hypomyelinating disorder characterized by early impairment of motor development, nystagmus, choreoathetotic movements, ataxia and progressive spasticity. PMD is caused by variations in the proteolipid protein gene PLP1, which encodes the two major myelin proteins of the central nervous system, PLP and its spliced isoform DM20, in oligodendrocytes. Large duplications including the entire PLP1 gene are the most frequent causative mutation leading to the classical form of PMD. The Plp1 overexpressing mouse model (PLP‐tg66/66) develops a phenotype very similar to human PMD, with early and severe motor dysfunction and a dramatic decrease in lifespan. The sequence of cellular events that cause neurodegeneration and ultimately death is poorly understood. In this work, we analyzed patient‐derived fibroblasts and spinal cords of the PLP‐tg66/66 mouse model, and identified redox imbalance, with altered antioxidant defense and oxidative damage to several enzymes involved in ATP production, such as glycolytic enzymes, creatine kinase and mitochondrial proteins from the Krebs cycle and oxidative phosphorylation. We also evidenced malfunction of the mitochondria compartment with increased ROS production and depolarization in PMD patient''s fibroblasts, which was prevented by the antioxidant N‐acetyl‐cysteine. Finally, we uncovered an impairment of mitochondrial dynamics in patient''s fibroblasts which may help explain the ultrastructural abnormalities of mitochondria morphology detected in spinal cords from PLP‐tg66/66 mice. Altogether, these results underscore the link between redox and metabolic homeostasis in myelin diseases, provide insight into the pathophysiology of PMD, and may bear implications for tailored pharmacological intervention. 相似文献
9.
10.